Jannik Sinner vs Adrian Mannarino Prediction & Picks - ATP Cincinnati Open

Prediction published on 8/13/25, 9:52 AM  by Lou Aguila | Modified on 8/13/25 at 9:15 PM in ATP Cincinnati Open Picks

Can Jannik Sinner win by at least seven games against Adrian Mannarino?

After blasting his first two opponents, the world’s No.1 will try to maintain his almost invincible form at the 2025 Cincinnati Open as he shoots for a place in the quarterfinals against the gritty veteran, Adrian Mannarino, on Wednesday.

Sinner opened on DraftKings as an overwhelming favorite at -2500. Arguably the best men’s singles player in the world right now, Sinner has shown minimal flaws in his victories over Daniel Elahi Galan 6-1, 6-1 and Gabriel Diallo 6-2, 7-5. The Italian has now won his last 9 matches, coming off a title run at the 2025 Wimbledon Open.

Mannarino reached the round of 16 with a 5-7, 6-3, 6-4 upset over Tommy Paul of the United States. The Frenchman won 80 percent of his first serves to surrender only two breakpoints out of 16 service games played. He also seized three breakpoints, two of which in the third set, to pull off the comeback.