Seattle Seahawks vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Seattle Seahawks
1/3/26 20:00
San Francisco 49ers

Prediction:

 

San Francisco 49ers +1.5

-108
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 by Matt Lowrimore in NFL Picks

Week 18 of the NFL will feature two Saturday games, one of which will see the San Francisco 49ers take on the Seattle Seahawks. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Seahawks.

Seattle enters this game with a record of 13-3, having most recently beaten the Carolina Panthers in Week 17 by a score of 27-10. The Seahawks’ offense had a total of 288 yards, while its defense allowed 139 yards. Quarterback Sam Darnold threw for 147 yards, one touchdown, and one interception, while running back Zach Charbonnet led the team in rushing with 110 yards and two touchdowns.

As for San Francisco, they enter this game with a record of 12-4, having most recently beaten the Chicago Bears in Week 17 by a score of 42-38. The 49ers’ offense had a total of 496 yards, while its defense allowed 440 yards. Quarterback Brock Purdy threw for 303 yards, three touchdowns, and one interception, while running back Christian McCaffrey led the team in rushing with 140 yards and one touchdown.

Seattle Seahawks vs San Francisco 49ers Form

Table

Teams % P W D L
1
Seattle Seahawks
Seattle Seahawks
0.813 16 13 0 3
5
San Francisco 49ers
San Francisco 49ers
0.75 16 12 0 4

Seattle Seahawks and San Francisco 49ers Latest Matches

Seattle Seahawks
Seattle Seahawks Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Dec 28, 2025 - NFL

Seattle Seahawks
27 :  10
Carolina Panthers

Dec 18, 2025 - NFL

Los Angeles Rams
37 :  38
Seattle Seahawks

Dec 14, 2025 - NFL

Indianapolis Colts
16 :  18
Seattle Seahawks

Dec 7, 2025 - NFL

Seattle Seahawks
37 :  9
Atlanta Falcons

Nov 30, 2025 - NFL

Minnesota Vikings
0 :  26
Seattle Seahawks

Nov 23, 2025 - NFL

Seattle Seahawks
30 :  24
Tennessee Titans
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 18, 2025 - NFL

Los Angeles Rams
37 :  38
Seattle Seahawks

Dec 14, 2025 - NFL

Indianapolis Colts
16 :  18
Seattle Seahawks

Nov 30, 2025 - NFL

Minnesota Vikings
0 :  26
Seattle Seahawks

Nov 9, 2025 - NFL

Arizona Cardinals
22 :  44
Seattle Seahawks

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Tampa Bay Buccaneers
38 :  35
Seattle Seahawks
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 28, 2025 - NFL

Seattle Seahawks
27 :  10
Carolina Panthers

Dec 7, 2025 - NFL

Seattle Seahawks
37 :  9
Atlanta Falcons

Nov 23, 2025 - NFL

Seattle Seahawks
30 :  24
Tennessee Titans

Nov 16, 2025 - NFL

Seattle Seahawks
19 :  21
Los Angeles Rams

Nov 2, 2025 - NFL

Seattle Seahawks
38 :  14
Washington Commanders

Oct 12, 2025 - NFL

Seattle Seahawks
20 :  12
Jacksonville Jaguars
San Francisco 49ers
San Francisco 49ers Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Dec 28, 2025 - NFL

Chicago Bears
38 :  42
San Francisco 49ers

Dec 22, 2025 - NFL

San Francisco 49ers
48 :  27
Indianapolis Colts

Dec 14, 2025 - NFL

Tennessee Titans
24 :  37
San Francisco 49ers

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 28, 2025 - NFL

Chicago Bears
38 :  42
San Francisco 49ers

Dec 14, 2025 - NFL

Tennessee Titans
24 :  37
San Francisco 49ers

Nov 24, 2025 - NFL

Carolina Panthers
9 :  20
San Francisco 49ers

Nov 9, 2025 - NFL

Los Angeles Rams
42 :  26
San Francisco 49ers

Oct 19, 2025 - NFL

Atlanta Falcons
10 :  20
San Francisco 49ers

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 22, 2025 - NFL

San Francisco 49ers
48 :  27
Indianapolis Colts

Nov 30, 2025 - NFL

San Francisco 49ers
26 :  8
Cleveland Browns

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 2, 2025 - NFL

San Francisco 49ers
34 :  24
New York Giants

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 12, 2025 - NFL

San Francisco 49ers
19 :  30
Tampa Bay Buccaneers

Seattle Seahawks against San Francisco 49ers : Head to Head (H2H)

Seattle Seahawks

33 %

Draw

0 %

San Francisco 49ers

67 %

Sep 7, 2025 - NFL

San Francisco 49ers
17 :  13
Seattle Seahawks

Nov 17, 2024 - NFL

Seattle Seahawks
20 :  17
San Francisco 49ers

Oct 10, 2024 - NFL

San Francisco 49ers
36 :  24
Seattle Seahawks

Nov 23, 2023 - NFL

San Francisco 49ers
31 :  13
Seattle Seahawks

Jan 14, 2023 - NFL

Seattle Seahawks
23 :  41
San Francisco 49ers

Nov 1, 2020 - NFL

San Francisco 49ers
27 :  37
Seattle Seahawks

Seattle Seahawks - San Francisco 49ers Key Points

  1. Seattle is 7-1 SU on the road
  2. Seattle is 6-0 SU in their last 6 games
  3. San Francisco is 5-2 SU at home
  4. San Francisco is 6-0 SU in their last 6 games

Our Seattle Seahawks vs San Francisco 49ers Prediction

The Seahawks are the small road favorites; however, the 49ers look to be the best betting option. This game has a lot at stake as the winner will also win the NFC West division and earn the number one seed in the NFC playoffs. 

The 49ers have already beaten the Seahawks this season, albeit all the way back in Week 1. Both teams are also on a tear, having won their last six games in a row. That being said, the 49ers seemingly have the X-factor in this matchup with Christian McCaffrey. He has been the focal point for this offense and has proven he can do just about everything.

Even though the Seahawks have only lost one road game this season, our San Francisco 49ers vs Seattle Seahawks prediction is: San Francisco 49ers +1.5.

Prediction:

 

San Francisco 49ers +1.5

-108
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Seattle Seahawks vs San Francisco 49ers Picks