Arizona Cardinals vs Seattle Seahawks Prediction & Picks - NFL

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Arizona Cardinals
9/25/25 20:15
Seattle Seahawks

Prediction:

 

Seattle ML

-104
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 by Travis Pulver | in NFL Picks

Thursday Night Football will feature an NFC West battle with the Arizona Cardinals hosting the Seattle Seahawks at State Farm Stadium in Glendale. Kickoff is scheduled for 8:15 p.m. EST on Thursday, Sept. 25.

Arizona got off to a hot start with a win in Week 1 over the New Orleans Saints, 20-13. They followed that with another win, this time over the Carolina Panthers 27-22. But the good times were not meant to last, and they lost to the 49ers in Week 3, 16-15. The offense has been methodical and efficient this season, not explosive. Luckily, the defense has been up to the task. It ranks towards the bottom of the league in total yards allowed per game (340.7, No. 23), but towards the top in scoring (17 ppg, No. 5). As for the Seahawks, after a disappointing performance in the season opener, a 17-13 loss to the 49ers, they have bounced back with two solid wins, one vs. the Steelers (31-17) and the other vs. the Saints (44-13). Sam Darnold had an incredibly efficient game against the Saints, completing 14 of 18 passes for 218 yards and a pair of touchdowns. He is one of ten quarterbacks with a 100+ rating for the season through three weeks (104.

Arizona Cardinals vs Seattle Seahawks Form

Table

Teams Pts P W L
1 Seattle Seahawks
0.824 17 14 3
30 Arizona Cardinals
0.176 17 3 14

Arizona Cardinals and Seattle Seahawks Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 10, 2024 - NFL

Arizona Cardinals
31 :  6
New York Jets

Nov 3, 2024 - NFL

Arizona Cardinals
29 :  9
Chicago Bears
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 1, 2024 - NFL

Minnesota Vikings
23 :  22
Arizona Cardinals

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals
Seattle Seahawks
Seattle Seahawks Latest matches
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Sep 14, 2025 - NFL

Pittsburgh Steelers
17 :  31
Seattle Seahawks

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 26, 2024 - NFL

Chicago Bears
3 :  6
Seattle Seahawks

Dec 22, 2024 - NFL

Seattle Seahawks
24 :  27
Minnesota Vikings
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Dec 22, 2024 - NFL

Seattle Seahawks
24 :  27
Minnesota Vikings

Dec 15, 2024 - NFL

Seattle Seahawks
13 :  30
Green Bay Packers

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals

Nov 3, 2024 - NFL

Seattle Seahawks
20 :  26
Los Angeles Rams
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 14, 2025 - NFL

Pittsburgh Steelers
17 :  31
Seattle Seahawks

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 26, 2024 - NFL

Chicago Bears
3 :  6
Seattle Seahawks

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Dec 1, 2024 - NFL

New York Jets
21 :  26
Seattle Seahawks

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks

Arizona Cardinals against Seattle Seahawks : Head to Head (H2H)

Arizona Cardinals

0 %

Seattle Seahawks

100 %

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals

Jan 7, 2024 - NFL

Arizona Cardinals
20 :  21
Seattle Seahawks

Nov 6, 2022 - NFL

Arizona Cardinals
21 :  31
Seattle Seahawks

Arizona Cardinals - Seattle Seahawks Key Points

  1. Seattle leads the all-time series vs. Arizona 29-22-1 and has won eight of the last ten meetings.
  2. The OVER is 16-16 in division games for Arizona since 2020; the OVER is 13-20 for Seattle in division games since 2020.
  3. Arizona is 13-19 ATS in division games since 2020; Seattle is 14-19 ATS in division games since 2020.
  4. Betting Public: In early returns, 59% of moneyline tickets are on Arizona, but 91% of the handle is on Seattle.

Our Arizona Cardinals vs Seattle Seahawks Prediction

It is hard to know just what to think about either team heading into this game. The Arizona defense played well vs. the Saints and Panthers in their two wins. But the offense was only sufficient, and it's not like either team is very good. Seattle beat up a poor Sanits team but played well overall against a decent Steelers team. I have to go with the Seahawks. Both defenses appear to be solid, but the Seattle offense has shown more signs of life. In the end, I think they’ll find a way to win.

Our Seahawks vs. Cardinals: Seattle ML

Prediction:

 

Seattle ML

-104
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Arizona Cardinals vs Seattle Seahawks Picks