Seattle Mariners vs Houston Astros Prediction & Picks - MLB

USA - MLB

Seattle Mariners
9/20/25 19:10
Houston Astros

Prediction:

 

Houston -110

-110
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 by Travis Pulver in MLB Picks

The Astros will host the Seattle Mariners in Game Two of a three-game weekend series at Daikin Park in Houston, TX, today. First Pitch for this AL West battle for control of the division pennant is scheduled for 7:10 p.m. EST. The game will be broadcast on MLB TV.

After Friday’s 4-0 win over the Astros, the Mariners slid into first in the AL West. Houston has held the top spot in the division for most of the season but has played inconsistently down the stretch (6-4 in their last ten) while the Mariners have been winning games (9-1 in their last ten). But Houston has the easier road in the final week with three vs. the A’s in Sacramento and three vs. the Angels in LA. The Mariners have a series vs. the Rockies and the Dodgers. The pitching matchup favors the Astros today with Framber Valdez (12-10, 3.59 ERA) taking the mound against George Kirby (9-7, 4.46 ERA). Valdez has struggled this month, posting a 7.88 ERA through three games, but has been solid at home this season (6-3 in 14 starts with a 2.21 ERA and .217 OBA. Kirby has had some issues on the road, posting a 4-4 record in ten starts with a 5.74 ERA and .285 OBA.

Seattle Mariners vs Houston Astros Form

Table

Teams % P W L
7
Seattle Mariners
Seattle Mariners
0.558 156 87 69
11
Houston Astros
Houston Astros
0.538 156 84 72

Seattle Mariners and Houston Astros Latest Matches

Seattle Mariners
Seattle Mariners Latest matches
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 19, 2025 - MLB

Seattle Mariners
4 :  0
Houston Astros

Sep 18, 2025 - MLB

Seattle Mariners
2 :  0
Kansas City Royals

Sep 17, 2025 - MLB

Seattle Mariners
5 :  7
Kansas City Royals

Sep 16, 2025 - MLB

Seattle Mariners
12 :  5
Kansas City Royals

Sep 14, 2025 - MLB

Los Angeles Angels
2 :  11
Seattle Mariners

Sep 13, 2025 - MLB

Los Angeles Angels
3 :  5
Seattle Mariners
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 14, 2025 - MLB

Los Angeles Angels
2 :  11
Seattle Mariners

Sep 13, 2025 - MLB

Los Angeles Angels
3 :  5
Seattle Mariners

Sep 12, 2025 - MLB

Los Angeles Angels
1 :  2
Seattle Mariners

Sep 11, 2025 - MLB

Los Angeles Angels
6 :  7
Seattle Mariners

Sep 10, 2025 - MLB

St. Louis Cardinals
2 :  4
Seattle Mariners

Sep 9, 2025 - MLB

St. Louis Cardinals
3 :  5
Seattle Mariners
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 19, 2025 - MLB

Seattle Mariners
4 :  0
Houston Astros

Sep 18, 2025 - MLB

Seattle Mariners
2 :  0
Kansas City Royals

Sep 17, 2025 - MLB

Seattle Mariners
5 :  7
Kansas City Royals

Sep 16, 2025 - MLB

Seattle Mariners
12 :  5
Kansas City Royals

Sep 7, 2025 - MLB

Seattle Mariners
18 :  2
Atlanta Braves

Sep 6, 2025 - MLB

Seattle Mariners
10 :  2
Atlanta Braves
Houston Astros
Houston Astros Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 19, 2025 - MLB

Seattle Mariners
4 :  0
Houston Astros

Sep 17, 2025 - MLB

Texas Rangers
2 :  5
Houston Astros

Sep 16, 2025 - MLB

Texas Rangers
5 :  6
Houston Astros

Sep 15, 2025 - MLB

Texas Rangers
3 :  6
Houston Astros

Sep 14, 2025 - MLB

Houston Astros
3 :  8
Atlanta Braves

Sep 13, 2025 - MLB

Houston Astros
6 :  2
Atlanta Braves
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 19, 2025 - MLB

Seattle Mariners
4 :  0
Houston Astros

Sep 17, 2025 - MLB

Texas Rangers
2 :  5
Houston Astros

Sep 16, 2025 - MLB

Texas Rangers
5 :  6
Houston Astros

Sep 15, 2025 - MLB

Texas Rangers
3 :  6
Houston Astros

Sep 4, 2025 - MLB

New York Yankees
8 :  4
Houston Astros

Sep 3, 2025 - MLB

New York Yankees
7 :  8
Houston Astros
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Houston Astros
3 :  8
Atlanta Braves

Sep 13, 2025 - MLB

Houston Astros
6 :  2
Atlanta Braves

Sep 12, 2025 - MLB

Houston Astros
11 :  3
Atlanta Braves

Sep 11, 2025 - MLB

Houston Astros
0 :  6
Toronto Blue Jays

Sep 10, 2025 - MLB

Houston Astros
3 :  2
Toronto Blue Jays

Sep 9, 2025 - MLB

Houston Astros
3 :  4
Toronto Blue Jays

Seattle Mariners against Houston Astros : Head to Head (H2H)

Seattle Mariners

67 %

Houston Astros

33 %

Sep 19, 2025 - MLB

Seattle Mariners
4 :  0
Houston Astros

Jul 20, 2025 - MLB

Houston Astros
11 :  3
Seattle Mariners

Jul 19, 2025 - MLB

Houston Astros
6 :  7
Seattle Mariners

Jul 18, 2025 - MLB

Houston Astros
1 :  6
Seattle Mariners

May 25, 2025 - MLB

Seattle Mariners
3 :  5
Houston Astros

May 23, 2025 - MLB

Seattle Mariners
5 :  3
Houston Astros

Seattle Mariners - Houston Astros Key Points

  1. Houston leads the all-time series vs. Seattle 135-95 but trails the season series 5-6.
  2. Valdez has gone 6-5 in 17 starts at night with two complete games, a 2.82 ERA, and .229 OBA.
  3. Kirby has gone 5-7 in 16 night starts with a 4.75 ERA and .277 OBA.
  4. Betting Public: 89% of moneyline tickets are on the Mariners, but 71% of run line tickets are on Houston.

Our Seattle Mariners vs Houston Astros Prediction

Both teams certainly need this win. I’d like to give Houston an edge since Valdez has been the better pitcher over the course of the entire season. But his recent struggles can’t be ignored. With only 11% of moneyline tickets on the Astros but 42% of the handle, that tells me the sharps are backing Houston. I can see this game going either way, so I’m going to bet with the sharps.

Our Mariners vs. Astros Pick: Houston ML

Prediction:

 

Houston -110

-110
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Seattle Mariners vs Houston Astros Picks