Club Santos Laguna vs CF America Prediction & Picks - Liga MX

Mexico - Liga MX

Club Santos Laguna
4/4/26 23:10
CF America

Prediction:

 

Both Teams To Score No Draw - Yes

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 by Edgar Jibran | in Liga MX Picks

The last game in next Saturday night's Liga MX schedule will feature the clash between Santos Laguna and América. For this game, the bookies’ odds are supporting América to win this game, but it should be noted that this expectation is majorly based on Santos’ awful performance. However, it cannot be ignored that the match will be a must-win game for América, as they are currently sitting in eighth place in the standings.

Furthermore, although Santos Laguna is located at the bottom of the standings, they recently were able to secure a couple of victories over Puebla and Tijuana. In this regard, it’s also important to remember that they had a very decent performance against Cruz Azul some matchdays ago, so keeping a strong defensive performance will be key for them to compete in this game.

Meanwhile, América is having a disastrous season, and after losing the derby against Pumas UNAM before the international break, they are expected to show dominance over Santos. For this scenario to happen, players like Alex Zendejas, Raphael Veiga, and Brian Rodríguez are expected to show their best performances and get an early advantage if possible.

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Club Santos Laguna vs CF America Form

Table

Teams Pts P W D L GD
8 CF America
25 17 7 4 6 +3
18 Club Santos Laguna
12 17 3 3 11 -18

Club Santos Laguna and CF America Latest Matches

Club Santos Laguna
Club Santos Laguna Latest matches
L D L W L W
Victories

2/6 (33%)

Draw

1/6 (17%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

3.17 Total goals
83% BTTS
1.33 Goals scored
1.83 Goals conceded
100% Over 2.5
0% Under 2.5

Mar 22, 2026 - Liga MX

Club Santos Laguna
2 :  1
Puebla

Mar 14, 2026 - Liga MX

Chivas
3 :  0
Club Santos Laguna

Mar 8, 2026 - Liga MX

Tijuana
1 :  2
Club Santos Laguna

Mar 3, 2026 - Liga MX

Club Santos Laguna
1 :  2
CF Cruz Azul

Feb 27, 2026 - Liga MX

Queretaro
2 :  2
Club Santos Laguna

Feb 21, 2026 - Liga MX

Club Leon
2 :  1
Club Santos Laguna
W L D L L W
Victories

2/6 (33%)

Draw

1/6 (17%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

3 Total goals
83% BTTS
1.33 Goals scored
1.67 Goals conceded
83% Over 2.5
17% Under 2.5

Mar 22, 2026 - Liga MX

Club Santos Laguna
2 :  1
Puebla

Mar 3, 2026 - Liga MX

Club Santos Laguna
1 :  2
CF Cruz Azul

Feb 15, 2026 - Liga MX

Club Santos Laguna
1 :  2
Mazatlan FC

Jan 18, 2026 - Liga MX

Club Santos Laguna
2 :  2
FC Juarez

Jan 10, 2026 - Liga MX

Club Santos Laguna
1 :  3
Club Necaxa

Nov 9, 2025 - Liga MX

Club Santos Laguna
1 :  0
CF Pachuca
L L L D W L
Victories

1/6 (17%)

Draw

1/6 (17%)

Defeats

4/6 (67%)

Average stats (Last 6 matchs)

3.83 Total goals
67% BTTS
1 Goals scored
2.83 Goals conceded
100% Over 2.5
0% Under 2.5

Mar 14, 2026 - Liga MX

Chivas
3 :  0
Club Santos Laguna

Mar 8, 2026 - Liga MX

Tijuana
1 :  2
Club Santos Laguna

Feb 27, 2026 - Liga MX

Queretaro
2 :  2
Club Santos Laguna

Feb 21, 2026 - Liga MX

Club Leon
2 :  1
Club Santos Laguna

Feb 6, 2026 - Liga MX

Tigres UANL
5 :  1
Club Santos Laguna

Jan 30, 2026 - Liga MX

Pumas UNAM
4 :  0
Club Santos Laguna
CF America
CF America Latest matches
L W W W D L
Victories

3/6 (50%)

Draw

1/6 (17%)

Defeats

2/6 (33%)

Average stats (Last 6 matchs)

2 Total goals
50% BTTS
1.17 Goals scored
0.83 Goals conceded
33% Over 2.5
67% Under 2.5

Mar 21, 2026 - Liga MX

Pumas UNAM
1 :  0
CF America

Mar 18, 2026 - Concachampions

CF America
1 :  1
Philadelphia Union

Mar 15, 2026 - Liga MX

CF America
2 :  0
Mazatlan FC

Mar 10, 2026 - Concachampions

Philadelphia Union
0 :  1
CF America

Mar 7, 2026 - Liga MX

Queretaro
1 :  2
CF America

Mar 4, 2026 - Liga MX

CF America
1 :  2
FC Juarez
W D L L W D
Victories

2/6 (33%)

Draw

2/6 (33%)

Defeats

2/6 (33%)

Average stats (Last 6 matchs)

2.17 Total goals
50% BTTS
1 Goals scored
1.17 Goals conceded
33% Over 2.5
67% Under 2.5

Mar 18, 2026 - Concachampions

CF America
1 :  1
Philadelphia Union

Mar 15, 2026 - Liga MX

CF America
2 :  0
Mazatlan FC

Mar 4, 2026 - Liga MX

CF America
1 :  2
FC Juarez

Feb 28, 2026 - Liga MX

CF America
1 :  4
Tigres UANL

Feb 11, 2026 - Concachampions

CF America
0 :  0
CD Olimpia Tegucigalpa

Feb 7, 2026 - Liga MX

CF America
1 :  0
Monterrey
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Average stats (Last 6 matchs)

2.17 Total goals
33% BTTS
1.5 Goals scored
0.67 Goals conceded
50% Over 2.5
50% Under 2.5

Mar 21, 2026 - Liga MX

Pumas UNAM
1 :  0
CF America

Mar 10, 2026 - Concachampions

Philadelphia Union
0 :  1
CF America

Mar 7, 2026 - Liga MX

Queretaro
1 :  2
CF America

Feb 20, 2026 - Liga MX

Puebla
0 :  4
CF America

Feb 14, 2026 - Liga MX

Chivas
1 :  0
CF America

Feb 3, 2026 - Concachampions

CD Olimpia Tegucigalpa
1 :  2
CF America

Club Santos Laguna against CF America : Head to Head (H2H)

Club Santos Laguna

0 %

Draw

33 %

CF America

67 %

Average stats (last H2H results)

4
Total goals
66.67%
BTTS
1.17
Goals scored
2.83
Goals conceded
83.33%
Over 2.5
16.67%
Under 2.5

Oct 4, 2025 - Liga MX

CF America
3 :  0
Club Santos Laguna

Jan 25, 2025 - Liga MX

Club Santos Laguna
1 :  4
CF America

Oct 19, 2024 - Liga MX

CF America
3 :  0
Club Santos Laguna

Apr 6, 2024 - Liga MX

Club Santos Laguna
1 :  1
CF America

Oct 21, 2023 - Liga MX

CF America
4 :  3
Club Santos Laguna

Feb 4, 2023 - Liga MX

Club Santos Laguna
2 :  2
CF America

Club Santos Laguna against CF America Lineups: Starting 11

Club Santos Laguna

Formation : 4 - 3 - 1 - 2

1
C. Acevedo
35
K. Balanta
22
K. Picon
9
L. Di Yorio
17
E. Echeverria
5
A. Lopez
195
N. Cedillo
6
J. Guemez
21
F. Villalba
10
E. Bullaude
14
E. Orona
19
J. Zuniga
7
B. Rodriguez
23
R. Veiga
10
A. Zendejas
28
E. Sanchez
17
R. Dourado
3
I. Reyes
32
M. Vazquez
29
R. Juarez
5
K. Alvarez
30
R. Cota

Formation : 4 - 2 - 3 - 1

CF America

Substitutes

Club Santos Laguna
Club Santos Laguna
Goalkeeper

H. Holguin

Defender

H. Ortega

J. Abella

J. Perez

N. Cedillo 87'

J. Echilvestre

F. Villalba 80'

Midfielder

D. Medina

Forward

C. Dajome

L. Di Yorio 80'

R. Sordo

E. Bullaude 70'

J. Ocejo

T. Jimnez

A. Lopez 43'

CF America
CF America
Goalkeeper

F. Tapia

Defender

A. Mejia Montoya

K. Alvarez 79'

T. Espinosa

S. Caceres

Midfielder

A. Gutierrez

R. Veiga 79'

J. Dos Santos

R. Dourado 79'

A. Cervantes

V. Lima

E. Sanchez 16'

Forward

I. Violante

A. Zendejas 79'

P. Salas

J. Zuniga 67'

Missing players

Club Santos Laguna
Club Santos Laguna
Midfielder

C. Gruezo

Forward

C. Lozano

CF America
CF America
Goalkeeper

L. Malagon

Midfielder

D. Espinoza

Forward

V. Davila

Most goals and assists

CD Huachipato Club Santos Laguna
CD Huachipato CF America
Top Goalscorer
Argentina L. Di Yorio (6 Goals)
Top Goalscorer
Uruguay B. Rodriguez (6 Goals) USA A. Zendejas (6 Goals)
Best assists
Argentina E. Bullaude (4 Assists)
Best assists
USA A. Zendejas (4 Assists)

Club Santos Laguna - CF America Key Points

  1. Santos Laguna ended a four-game home winless streak with their most recent 2-1 victory over Puebla.
  2. América ended a three-game road winning streak with their 1-0 loss to Pumas UNAM.
  3. Santos Laguna hasn’t been able to keep a clean sheet when playing at home throughout this season.
  4. América should try to get a significant advantage as early as possible in this game, as next week they will play the first leg of the CONCACAF Champions Cup against Nashville SC.
Up to $200 to bet on Club Santos Laguna - CF America! 

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Our Club Santos Laguna vs CF America Prediction

When reviewing all these facts, it makes sense that the odds are heavily supporting América to win this game; however, the expected dominant performance from this team could be far from reality due to América’s divided focus between the league and the Champions Cup.

To conclude, this game could become one of the most entertaining of the weekend in terms of scoring goals, as neither defense has been able to show a solid performance throughout the regular season. Therefore, the pick for Club Santos Laguna – Club América is: Both Teams To Score No Draw - Yes!

Prediction:

 

Both Teams To Score No Draw - Yes

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$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Club Santos Laguna vs CF America Picks