Atletico San Luis vs Club Santos Laguna Prediction & Picks - Liga MX

Mexico - Liga MX

Atletico San Luis
4/22/26 21:00
Club Santos Laguna

Prediction:

 

Both Teams To Score No Draw - Yes

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 by Edgar Jibran | in Liga MX Picks

Next Wednesday night is expected to be one of the saddest nights of the season at Libertad Financiera Stadium, as Atlético San Luis will face Santos Laguna with no motivation after losing their chances to qualify for the playoffs with their 2-0 loss to Pumas UNAM last weekend. Despite this, João Pedro is expected to take advantage of Santos’ bad defensive performance to score at least one goal that could help him in his goalscorer title run.

However, it’s a fact that Atlético San Luis has struggled to achieve offensive effectiveness, and even though they were able to make 27 shots during their game against Pumas, only three of them were on goal. With this context in mind, players like Sebastien Salles-Lamonge and Jesús Medina are expected to increase their offensive participation to support João Pedro in scoring goals easily.

Meanwhile, Santos Laguna have consistently demonstrated that they are the current worst Mexican team; nevertheless, these kinds of games are those in which this team normally gets positive outcomes. In this regard, it should be noted that the only remaining objective for this team will be to avoid sitting in the last spot of the standings by the end of the regular season.

Atletico San Luis vs Club Santos Laguna Form

Table

Teams Pts P W D L GD
14 Atletico San Luis
18 17 5 3 9 -3
18 Club Santos Laguna
12 17 3 3 11 -18

Atletico San Luis and Club Santos Laguna Latest Matches

Atletico San Luis
Atletico San Luis Latest matches
L D L W D L
Victories

1/6 (17%)

Draw

2/6 (33%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

2.5 Total goals
67% BTTS
0.83 Goals scored
1.67 Goals conceded
50% Over 2.5
50% Under 2.5

Apr 17, 2026 - Liga MX

Atletico San Luis
0 :  2
Pumas UNAM

Apr 12, 2026 - Liga MX

Deportivo Toluca FC
1 :  1
Atletico San Luis

Apr 4, 2026 - Liga MX

Monterrey
1 :  2
Atletico San Luis

Mar 21, 2026 - Liga MX

Atletico San Luis
1 :  2
Club Leon

Mar 14, 2026 - Liga MX

Atletico San Luis
1 :  1
CF Pachuca

Mar 7, 2026 - Liga MX

CF Cruz Azul
3 :  0
Atletico San Luis
W L W D L L
Victories

2/6 (33%)

Draw

1/6 (17%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

2.67 Total goals
50% BTTS
1.5 Goals scored
1.17 Goals conceded
50% Over 2.5
50% Under 2.5

Apr 17, 2026 - Liga MX

Atletico San Luis
0 :  2
Pumas UNAM

Mar 21, 2026 - Liga MX

Atletico San Luis
1 :  2
Club Leon

Mar 14, 2026 - Liga MX

Atletico San Luis
1 :  1
CF Pachuca

Mar 3, 2026 - Liga MX

Atletico San Luis
4 :  1
Mazatlan FC

Feb 28, 2026 - Liga MX

Atletico San Luis
0 :  1
Puebla

Feb 14, 2026 - Liga MX

Atletico San Luis
3 :  0
Queretaro
D L L L W D
Victories

1/6 (17%)

Draw

2/6 (33%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

3.33 Total goals
83% BTTS
1.17 Goals scored
2.17 Goals conceded
67% Over 2.5
33% Under 2.5

Apr 12, 2026 - Liga MX

Deportivo Toluca FC
1 :  1
Atletico San Luis

Apr 4, 2026 - Liga MX

Monterrey
1 :  2
Atletico San Luis

Mar 7, 2026 - Liga MX

CF Cruz Azul
3 :  0
Atletico San Luis

Feb 21, 2026 - Liga MX

Atlas FC
3 :  2
Atletico San Luis

Feb 6, 2026 - Liga MX

Club Necaxa
4 :  1
Atletico San Luis

Jan 17, 2026 - Liga MX

Tijuana
1 :  1
Atletico San Luis
Club Santos Laguna
Club Santos Laguna Latest matches
W L W D L L
Victories

2/6 (33%)

Draw

1/6 (17%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

3 Total goals
67% BTTS
1.17 Goals scored
1.83 Goals conceded
67% Over 2.5
33% Under 2.5

Apr 19, 2026 - Liga MX

Club Santos Laguna
0 :  1
Atlas FC

Apr 11, 2026 - Liga MX

CF Pachuca
4 :  2
Club Santos Laguna

Apr 4, 2026 - Liga MX

Club Santos Laguna
1 :  1
CF America

Mar 22, 2026 - Liga MX

Club Santos Laguna
2 :  1
Puebla

Mar 14, 2026 - Liga MX

Chivas
3 :  0
Club Santos Laguna

Mar 8, 2026 - Liga MX

Tijuana
1 :  2
Club Santos Laguna
D L L W D L
Victories

1/6 (17%)

Draw

2/6 (33%)

Defeats

3/6 (50%)

Average stats (Last 6 matchs)

2.67 Total goals
83% BTTS
1.17 Goals scored
1.5 Goals conceded
67% Over 2.5
33% Under 2.5

Apr 19, 2026 - Liga MX

Club Santos Laguna
0 :  1
Atlas FC

Apr 4, 2026 - Liga MX

Club Santos Laguna
1 :  1
CF America

Mar 22, 2026 - Liga MX

Club Santos Laguna
2 :  1
Puebla

Mar 3, 2026 - Liga MX

Club Santos Laguna
1 :  2
CF Cruz Azul

Feb 15, 2026 - Liga MX

Club Santos Laguna
1 :  2
Mazatlan FC

Jan 18, 2026 - Liga MX

Club Santos Laguna
2 :  2
FC Juarez
L L D W L L
Victories

1/6 (17%)

Draw

1/6 (17%)

Defeats

4/6 (67%)

Average stats (Last 6 matchs)

4.17 Total goals
83% BTTS
1.33 Goals scored
2.83 Goals conceded
100% Over 2.5
0% Under 2.5

Apr 11, 2026 - Liga MX

CF Pachuca
4 :  2
Club Santos Laguna

Mar 14, 2026 - Liga MX

Chivas
3 :  0
Club Santos Laguna

Mar 8, 2026 - Liga MX

Tijuana
1 :  2
Club Santos Laguna

Feb 27, 2026 - Liga MX

Queretaro
2 :  2
Club Santos Laguna

Feb 21, 2026 - Liga MX

Club Leon
2 :  1
Club Santos Laguna

Feb 6, 2026 - Liga MX

Tigres UANL
5 :  1
Club Santos Laguna

Atletico San Luis against Club Santos Laguna : Head to Head (H2H)

Atletico San Luis

67 %

Draw

17 %

Club Santos Laguna

17 %

Average stats (last H2H results)

3.5
Total goals
66.67%
BTTS
2.33
Goals scored
1.17
Goals conceded
66.67%
Over 2.5
33.33%
Under 2.5

Sep 21, 2025 - Liga MX

Club Santos Laguna
1 :  4
Atletico San Luis

Mar 30, 2025 - Liga MX

Club Santos Laguna
2 :  3
Atletico San Luis

Sep 28, 2024 - Liga MX

Atletico San Luis
3 :  1
Club Santos Laguna

Apr 28, 2024 - Liga MX

Club Santos Laguna
0 :  3
Atletico San Luis

Nov 11, 2023 - Liga MX

Atletico San Luis
0 :  2
Club Santos Laguna

Feb 18, 2023 - Liga MX

Atletico San Luis
1 :  1
Club Santos Laguna
Atletico San Luis vs Club Santos Laguna Picks

Atletico San Luis against Club Santos Laguna Lineups: Starting 11

Atletico San Luis

Formation : 4 - 2 - 3 - 1

1
A. Sanchez
2
R. Torres Acosta
3
R. Bambu
31
E. Aguila
18
A. Cruz
5
R. Meraz
21
O. Macias
15
L. Esteves
11
D. Rodriguez
10
S. Salles-Lamonge
9
J. Pedro
9
L. Di Yorio
10
E. Bullaude
21
F. Villalba
6
J. Guemez
5
A. Lopez
8
S. Mariscal
17
E. Echeverria
2
B. Amione
35
K. Balanta
22
K. Picon
33
H. Holguin

Formation : 4 - 3 - 1 - 2

Club Santos Laguna

Substitutes

Atletico San Luis
Atletico San Luis
Goalkeeper

M. Lajud

Defender

J. Dominguez

O. Macias 90'

Juanpe

E. Aguila 77'

Midfielder

M. Garcia

S. Bouquet Perez

Forward

B. Galdames

S. Munoz

D. Rodriguez 76'

A. Duarte

R. Meraz 57'

L. Flores

L. Esteves 45'

F. Barajas

Club Santos Laguna
Club Santos Laguna
Goalkeeper

C. Acevedo

Defender

H. Ortega

E. Orona

J. Abella

K. Picon 90'

Midfielder

D. Medina

N. Cedillo

L. Gomez

A. Lopez 70'

Forward

R. Sordo

F. Villalba 90'

T. Jimenez

S. Mariscal 90'

C. Dajome

E. Bullaude 81'

Missing players

Atletico San Luis
Atletico San Luis
Goalkeeper

C. Lopez

Club Santos Laguna
Club Santos Laguna
Midfielder

C. Gruezo

Most goals and assists

CD Huachipato Atletico San Luis
CD Huachipato Club Santos Laguna
Top Goalscorer
Italy J. Galvao (14 Goals)
Top Goalscorer
Argentina L. Di Yorio (6 Goals)
Best assists
France S. Salles-Lamonge (2 Assists)
Chile B. Galdames (2 Assists)
Best assists
Argentina E. Bullaude (4 Assists)

Atletico San Luis - Club Santos Laguna Key Points

  1. Atlético San Luis couldn’t keep a clean sheet during their last five home games, so they aren’t expected to overcome this negative trend.
  2. Santos Laguna scored at least one goal in four of their last five road games.
  3. Atlético San Luis have conceded at least one goal during their last four home meetings against Santos Laguna.
  4. Santos Laguna ended a three-game unbeaten streak when facing road meetings against Atlético San Luis with their most recent 3-1 loss in September 2024.

Our Atletico San Luis vs Club Santos Laguna Prediction

As can be seen, this game will be one of the most irrelevant on next Wednesday night due to the poor performance of both teams, but it makes sense to have Atlético San Luis as the favorite team to win.

Summarizing, this game is expected to be a great chance for Santos Laguna to avoid sitting in the last spot of the standings by the end of the regular season, so they are expected to cause significant damage to San Luis’ defense. Therefore, the pick for Atlético San Luis – Club Santos Laguna is: Both Teams To Score No Draw - Yes!

Prediction:

 

Both Teams To Score No Draw - Yes

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.