San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
8/20/25 21:40
San Diego Padres

Prediction:

 

San Diego ML

-152
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 by Travis Pulver in MLB Picks

The San Diego Padres will face the San Francisco Giants in the third game of a four-game series tonight at Petco Park. First Pitch for this NL West showdown is scheduled for 9:40 p.m. EST.

Last night’s 5-1 win over the visiting Giants gave the Padres win No. 70 of the season, but more importantly, it stopped a four-game losing skid.  So, of course, a win tonight will bring them a step closer to starting a new win streak (they had won five in a row before getting swept by the Dodgers in LA over the weekend). JP Sears is scheduled to start for the home team. Sears has a 7-10 record in 23 starts with a 5.12 ERA, 1.31 WHIP, and .267 OBA. He’s gone 3-5 in 10 home starts with an ERA of 5.48 and a .273 OBA. He’s started just one game since the Padres acquired him, and it didn’t go well (@ Arizona, Aug. 4). He lasted five innings, giving up ten hits (one home run), five earned runs, and a walk while striking out five. As for the Giants, Landen Roupp is set to start. The young righty is 7-6 in 21 starts with a 3.45 ERA, 1.45 WHIP, and .263 OBA.

San Francisco Giants vs San Diego Padres Form

Table

Teams % P W L
7
San Diego Padres
San Diego Padres
0.556 126 70 56
18
San Francisco Giants
San Francisco Giants
0.484 126 61 65

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 6, 2025 - MLB

San Francisco Giants
4 :  2
Pittsburgh Pirates

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Aug 3, 2025 - MLB

San Francisco Giants
12 :  4
New York Mets
San Diego Padres
San Diego Padres Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 10, 2025 - MLB

Boston Red Sox
2 :  6
San Diego Padres

Aug 9, 2025 - MLB

Boston Red Sox
4 :  5
San Diego Padres

Aug 8, 2025 - MLB

Boston Red Sox
10 :  2
San Diego Padres

Aug 3, 2025 - MLB

St. Louis Cardinals
3 :  7
San Diego Padres
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

33 %

San Diego Padres

67 %

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

San Francisco Giants - San Diego Padres Key Points

  1. San Francisco leads the all-time series vs. San Diego 497-458.
  2. The Padres have dominated the Giants this season, winning seven of ten meetings (to date).
  3. San Diego is 37-21 at home but only 37-32 following a win.
  4. Betting Public: 73% of moneyline tickets and 68% of the handle are on the Padres.

Our San Francisco Giants vs San Diego Padres Prediction

Neither starter is super impressive. But it may not matter, given how both teams have been hitting the ball of late. Over the last week, the Padres have been hitting .219; the Giants, .231. Sears has not been good for the Padres, nor was he strong for the A’s before the trade. But, luckily, the Padres have the best bullpen in baseball. If the Giants start to rough him up a little, they’ll pull him and let the pen do the heavy lifting. Because of that, I’m leaning towards taking the Padres to win.

Our Giants vs. Padres Pick: San Diego ML

Prediction:

 

San Diego ML

-152
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San Francisco Giants vs San Diego Padres Picks