San Francisco Giants vs San Diego Padres Prediction & Picks - MLB

USA - MLB

San Francisco Giants
8/21/25 16:10
San Diego Padres

Prediction:

 

Padres -1.5.

+126
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 by Carlos Zabala in MLB Picks

All things considered, it doesn't seem like the Giants made the right call in signing veteran Justin Verlander for the 2025 season; In his penultimate month of competition with the Giants, the former Cy Young Award winner has posted a 1-9 record so far and, heading into Thursday's game against the Padres, has a 4.23 ERA.

However, Verlander has shown encouraging signs of recovery, such as when he earned his first W of the season against the Braves on July 23, and had his best outing ever for the Giants, pitching seven innings of just two hits and striking out eight. But he hasn't been very consistent.

The Padres had swept the Giants at Oracle Park in the series that began August 11, before being swept by the Dodgers in Los Angeles and losing the division lead.

In a part of the year that will define many things, the Padres, after this 4-game series against the Giants in San Diego, will once again host the Dodgers. Before being swept in Los Angeles, the Padres won 5 games in a row.

San Francisco Giants vs San Diego Padres Form

Table

Teams % P W L
7
San Diego Padres
San Diego Padres
0.556 126 70 56
18
San Francisco Giants
San Francisco Giants
0.484 126 61 65

San Francisco Giants and San Diego Padres Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 6, 2025 - MLB

San Francisco Giants
4 :  2
Pittsburgh Pirates

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Aug 3, 2025 - MLB

San Francisco Giants
12 :  4
New York Mets
San Diego Padres
San Diego Padres Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 10, 2025 - MLB

Boston Red Sox
2 :  6
San Diego Padres

Aug 9, 2025 - MLB

Boston Red Sox
4 :  5
San Diego Padres

Aug 8, 2025 - MLB

Boston Red Sox
10 :  2
San Diego Padres

Aug 3, 2025 - MLB

St. Louis Cardinals
3 :  7
San Diego Padres
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants

San Francisco Giants against San Diego Padres : Head to Head (H2H)

San Francisco Giants

33 %

San Diego Padres

67 %

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Aug 18, 2025 - MLB

San Francisco Giants
4 :  3
San Diego Padres

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants

Jun 5, 2025 - MLB

San Diego Padres
2 :  3
San Francisco Giants

San Francisco Giants - San Diego Padres Key Points

  1. Padres and Giants among the 6 MLB teams with the fewest home runs in 2025
  2. The Padres' pitching BAA, best in the MLB at 225
  3. Padres' 31-16 record as betting favorites at Petco Park
  4. Merrill injured by the Padres; Chapman injured by the Giants

Our San Francisco Giants vs San Diego Padres Prediction

The Verlander-Giolito duel is scheduled for Game 3 of the Giants-Padres series; On Tuesday, the Padres started as -155 favorites with Sears pitching, and the Padres won easily, taking Game 1 5-1.

In the series opener, Pivetta and the Padres' excellent bullpen held the Giants to just four hits, while the Giants struck out 12 times in the series opener.

Our prediction for Padres vs Giants is: Padres -1.5.

Prediction:

 

Padres -1.5.

+126
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San Francisco Giants vs San Diego Padres Picks