San Francisco Giants vs Pittsburgh Pirates Prediction & Picks - MLB

USA - MLB

San Francisco Giants
8/6/25 12:35
Pittsburgh Pirates

Prediction:

 

The Pirates will win

+126
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 by Lou Aguila in MLB Picks

The San Francisco Giants and the Pittsburgh Pirates are heading into a rubber match on Wednesday at PNC Park after splitting the first two games of their series.

The Giants opened the betting lines as the favorites at -148 on FanDuel. On Tuesday, San Francisco is coming off a convincing 8-1 win over the Pirates. Willy Adames, Patrick Bailey and Christian Kross each drove two RBIs, while Rafael Davers and Jerar Encarnacion each chipped in one RBIs. The Giants also benefited from an impeccable mound performance by Logan Webb, who surrendered one earned run with 10 strikeouts over six innings.

The Pirates are listed as +126 underdogs on FanDuel following their heavy loss to the Giants. Pittsburgh came into Tuesday night’s ballgame with the Giants, averaging almost 8 runs per game on a .280 batting average in the past five games. Unfortunately, the Pirates' offense was a non-factor with All-Star slugger Bryan Reynolds driving the lone run for his team in the game.

San Francisco Giants vs Pittsburgh Pirates Form

Table

Teams % P W L
16
San Francisco Giants
San Francisco Giants
0.5 114 57 57
26
Pittsburgh Pirates
Pittsburgh Pirates
0.43 114 49 65

San Francisco Giants and Pittsburgh Pirates Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Aug 3, 2025 - MLB

San Francisco Giants
12 :  4
New York Mets

Aug 2, 2025 - MLB

San Francisco Giants
6 :  12
New York Mets

Aug 1, 2025 - MLB

San Francisco Giants
4 :  3
New York Mets

Jul 30, 2025 - MLB

Pittsburgh Pirates
2 :  1
San Francisco Giants
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Jul 30, 2025 - MLB

Pittsburgh Pirates
2 :  1
San Francisco Giants

Jul 29, 2025 - MLB

Pittsburgh Pirates
3 :  1
San Francisco Giants

Jul 28, 2025 - MLB

Pittsburgh Pirates
6 :  5
San Francisco Giants

Jul 27, 2025 - MLB

New York Mets
5 :  3
San Francisco Giants

Jul 26, 2025 - MLB

New York Mets
2 :  1
San Francisco Giants

Jul 25, 2025 - MLB

New York Mets
8 :  1
San Francisco Giants
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Aug 3, 2025 - MLB

San Francisco Giants
12 :  4
New York Mets

Aug 2, 2025 - MLB

San Francisco Giants
6 :  12
New York Mets

Aug 1, 2025 - MLB

San Francisco Giants
4 :  3
New York Mets

Jul 23, 2025 - MLB

San Francisco Giants
9 :  3
Atlanta Braves
Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Aug 3, 2025 - MLB

Pittsburgh Pirates
9 :  5
Colorado Rockies

Aug 2, 2025 - MLB

Pittsburgh Pirates
5 :  8
Colorado Rockies

Aug 1, 2025 - MLB

Pittsburgh Pirates
16 :  17
Colorado Rockies

Jul 30, 2025 - MLB

Pittsburgh Pirates
2 :  1
San Francisco Giants
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Jul 27, 2025 - MLB

Arizona Diamondbacks
0 :  6
Pittsburgh Pirates

Jul 26, 2025 - MLB

Arizona Diamondbacks
0 :  2
Pittsburgh Pirates

Jul 25, 2025 - MLB

Arizona Diamondbacks
1 :  0
Pittsburgh Pirates

Jul 23, 2025 - MLB

Detroit Tigers
1 :  6
Pittsburgh Pirates
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 3, 2025 - MLB

Pittsburgh Pirates
9 :  5
Colorado Rockies

Aug 2, 2025 - MLB

Pittsburgh Pirates
5 :  8
Colorado Rockies

Aug 1, 2025 - MLB

Pittsburgh Pirates
16 :  17
Colorado Rockies

Jul 30, 2025 - MLB

Pittsburgh Pirates
2 :  1
San Francisco Giants

Jul 29, 2025 - MLB

Pittsburgh Pirates
3 :  1
San Francisco Giants

Jul 28, 2025 - MLB

Pittsburgh Pirates
6 :  5
San Francisco Giants

San Francisco Giants against Pittsburgh Pirates : Head to Head (H2H)

San Francisco Giants

17 %

Pittsburgh Pirates

83 %

Aug 5, 2025 - MLB

San Francisco Giants
8 :  1
Pittsburgh Pirates

Aug 4, 2025 - MLB

San Francisco Giants
4 :  5
Pittsburgh Pirates

Jul 30, 2025 - MLB

Pittsburgh Pirates
2 :  1
San Francisco Giants

Jul 29, 2025 - MLB

Pittsburgh Pirates
3 :  1
San Francisco Giants

Jul 28, 2025 - MLB

Pittsburgh Pirates
6 :  5
San Francisco Giants

May 21, 2024 - MLB

San Francisco Giants
6 :  7
Pittsburgh Pirates

San Francisco Giants - Pittsburgh Pirates Key Points

  1. Pittsburgh is 6-2 SU in its last 8 games at home.
  2. Pittsburgh is 10-4 SU in its last 14 games.
  3. San Francisco is 5-14 SU in its last 19 games.
  4. San Francisco is 1-4 SU in its last 5 games against Pittsburgh.

Our San Francisco Giants vs Pittsburgh Pirates Prediction

Tuesday’s win ended the Giants’ four-game losing streak against the Pirates. San Francisco has a solid chance to establish a winning streak with Robbie Ray starting in the series finale. Ray (2-3, 3.45 ERA in the last 5 starts) will be pitching against the Pirates for the first time since 2019. In his last start vs. the Mets, Ray yielded one run with 6 strikeouts to help the Giants secure a 4-3 win over the Mets on Aug 1.

The Pirates will send Andrew Heaney (2-3, 5.73 ERA in his last 5). Heaney allowed 3 runs in 3.1 innings in the Pirates 16-17 loss to the Colorado Rockies on August 1. Pittsburgh is 6-2 SU in its last 8 games at home and 4-1 in their last 5 vs. the Giants.

I see a ton of value in betting on Pittsburgh at the +126 moneyline. I feel the Pirates will put up a better effort in the series finale after the embarrassment they suffered at home on Tuesday. This team’s offense has been so explosive in the past five games (7.7 runs per game) that they can rip a game apart with just one massive rally. Although giving up an 8.52 ERA in the last five games is certainly worrying, I believe their starter, Andrew Heaney, will deliver decent numbers on the mound on Tuesday, putting his team in a position to win.

Our betting prediction for the Pittsburgh Pirates vs. the San Francisco Giants: the Pirates will win.

Prediction:

 

The Pirates will win

+126
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San Francisco Giants vs Pittsburgh Pirates Picks