San Francisco Giants vs Los Angeles Dodgers Prediction & Picks - MLB

USA - MLB

San Francisco Giants
9/21/25 16:10
Los Angeles Dodgers

Prediction:

 

The Dodgers -1.5 Runs

-110
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 by Lou Aguila in MLB Picks

The Detroit Tigers will try to complete a four-game sweep of the San Francisco Giants in the final game of their series on Sunday at Dodger Stadium.

The Dodgers, 8-2 in their last 10 meetings against the Giants, are valued at -110 on a -1.5 runline.

Current Form:

The Dodgers continued their mastery over the Giants, as they rallied from a 0-4 hole to hack out a 7-5 comeback win on Saturday. With the win, Los Angeles (88-67) has padded their lead over the San Diego Padres (84-67) to four games, inching closer to locking up the NL West title. The Dodgers are 4-0 in their last four games and 8-2 in their last 10 games at home.

Saturday’s loss sent the Giants to the brink of elimination as they are now four games off a wild-card spot. San Francisco is 1-4 in their last 5 games, during which they have posted a .164 batting average while averaging 3.6 runs per game.

Pitchers Matchup:

Giants RHP Trevor McDonald (0-0, 9.00 ERA) vs. Dodgers RHP Emett Sheehan (6-3, 3.17 ERA).

San Francisco Giants vs Los Angeles Dodgers Form

Table

Teams % P W L
4
Los Angeles Dodgers
Los Angeles Dodgers
0.568 155 88 67
18
San Francisco Giants
San Francisco Giants
0.49 155 76 79

San Francisco Giants and Los Angeles Dodgers Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 20, 2025 - MLB

San Francisco Giants
5 :  7
Los Angeles Dodgers

Sep 19, 2025 - MLB

San Francisco Giants
3 :  6
Los Angeles Dodgers

Sep 18, 2025 - MLB

San Francisco Giants
1 :  2
Los Angeles Dodgers

Sep 17, 2025 - MLB

San Francisco Giants
5 :  1
Arizona Diamondbacks

Sep 16, 2025 - MLB

San Francisco Giants
5 :  6
Arizona Diamondbacks

Sep 15, 2025 - MLB

San Francisco Giants
1 :  8
Arizona Diamondbacks
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Los Angeles Dodgers
10 :  2
San Francisco Giants

Sep 13, 2025 - MLB

Los Angeles Dodgers
13 :  7
San Francisco Giants

Sep 12, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Francisco Giants

Sep 10, 2025 - MLB

Arizona Diamondbacks
5 :  3
San Francisco Giants

Sep 9, 2025 - MLB

Arizona Diamondbacks
3 :  5
San Francisco Giants

Sep 8, 2025 - MLB

Arizona Diamondbacks
5 :  11
San Francisco Giants
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 20, 2025 - MLB

San Francisco Giants
5 :  7
Los Angeles Dodgers

Sep 19, 2025 - MLB

San Francisco Giants
3 :  6
Los Angeles Dodgers

Sep 18, 2025 - MLB

San Francisco Giants
1 :  2
Los Angeles Dodgers

Sep 17, 2025 - MLB

San Francisco Giants
5 :  1
Arizona Diamondbacks

Sep 16, 2025 - MLB

San Francisco Giants
5 :  6
Arizona Diamondbacks

Sep 15, 2025 - MLB

San Francisco Giants
1 :  8
Arizona Diamondbacks
Los Angeles Dodgers
Los Angeles Dodgers Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 20, 2025 - MLB

San Francisco Giants
5 :  7
Los Angeles Dodgers

Sep 19, 2025 - MLB

San Francisco Giants
3 :  6
Los Angeles Dodgers

Sep 18, 2025 - MLB

San Francisco Giants
1 :  2
Los Angeles Dodgers

Sep 17, 2025 - MLB

Philadelphia Phillies
0 :  5
Los Angeles Dodgers

Sep 16, 2025 - MLB

Philadelphia Phillies
9 :  6
Los Angeles Dodgers

Sep 15, 2025 - MLB

Philadelphia Phillies
6 :  5
Los Angeles Dodgers
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 20, 2025 - MLB

San Francisco Giants
5 :  7
Los Angeles Dodgers

Sep 19, 2025 - MLB

San Francisco Giants
3 :  6
Los Angeles Dodgers

Sep 18, 2025 - MLB

San Francisco Giants
1 :  2
Los Angeles Dodgers

Sep 17, 2025 - MLB

Philadelphia Phillies
0 :  5
Los Angeles Dodgers

Sep 16, 2025 - MLB

Philadelphia Phillies
9 :  6
Los Angeles Dodgers

Sep 15, 2025 - MLB

Philadelphia Phillies
6 :  5
Los Angeles Dodgers
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Los Angeles Dodgers
10 :  2
San Francisco Giants

Sep 13, 2025 - MLB

Los Angeles Dodgers
13 :  7
San Francisco Giants

Sep 12, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Francisco Giants

Sep 7, 2025 - MLB

Los Angeles Dodgers
5 :  2
Baltimore Orioles

Sep 6, 2025 - MLB

Los Angeles Dodgers
3 :  4
Baltimore Orioles

Sep 5, 2025 - MLB

Los Angeles Dodgers
1 :  2
Baltimore Orioles

San Francisco Giants against Los Angeles Dodgers : Head to Head (H2H)

San Francisco Giants

17 %

Los Angeles Dodgers

83 %

Sep 20, 2025 - MLB

San Francisco Giants
5 :  7
Los Angeles Dodgers

Sep 19, 2025 - MLB

San Francisco Giants
3 :  6
Los Angeles Dodgers

Sep 18, 2025 - MLB

San Francisco Giants
1 :  2
Los Angeles Dodgers

Sep 14, 2025 - MLB

Los Angeles Dodgers
10 :  2
San Francisco Giants

Sep 13, 2025 - MLB

Los Angeles Dodgers
13 :  7
San Francisco Giants

Sep 12, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Francisco Giants

San Francisco Giants - Los Angeles Dodgers Key Points

  1. San Francisco is 1-7 SU in its last 8 games.
  2. San Francisco is 0-5 SU in its last 5 games against LA Dodgers.
  3. LA Dodgers is 4-1 SU in its last 5 games.
  4. LA Dodgers is 8-2 SU in its last 10 games at home.

Our San Francisco Giants vs Los Angeles Dodgers Prediction

The Dodgers get a 63 percent win probability from ESPN Match Predictor for Sunday’s Game 4 vs. the Giants. Los Angeles has dominated their California rival all season long. In their last 10 meetings, the Dodgers have averaged 5.80 runs per game while limiting the Giants’ offense to an average of 3.80 runs per game. Emmett Sheehan has allowed three earned runs and recorded 25 strikeouts over 18.2 innings pitched across his last three starts. The Giants, who have only scored one run against Sheehan, opt to start relief pitcher Trevor McDonald for Sunday’s crucial game. San Francisco is 1-4 SU in its last 5 games on the road and 1-7 SU in its last 8 games.

Fearless Forecast: Dodgers 9, Giants 3

Our betting prediction for the Los Angeles Dodgers vs. the San Francisco Giants: the Dodgers -1.5 Runs

Prediction:

 

The Dodgers -1.5 Runs

-110
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San Francisco Giants vs Los Angeles Dodgers Picks