San Francisco Giants vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Francisco Giants
5/6/25 19:40
Chicago Cubs

Prediction:

 

Cubs -1.5 Runs

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 by Lou Aguila in MLB Picks

The San Francisco Giants will go for an equalizer as they attempt to recover from an embarrassing series-opening loss to the Chicago Cubs in Tuesday’s Game 2 at Wrigley Field.

The Giants absorbed a huge 2-9 loss to the Cubs in Game 1 of their series. San Francisco, 12th in the MLB with 166 runs, could only score two runs as the Cubs hurler completely smothered them from start to finish. With the loss, the Giants’ record dropped to 22-14, third in the NL West standings.

The Cubs reinforced their position atop the NL Central with the win on Tuesday. Chicago is currently the No.1 scoring team in the MLB, averaging 6.1 runs per game on a .263 batting average this season. The Cubs are mid in terms of pitching, but they will be sending probably their most consistent pitcher this season in Colin Rea (2-0, 1.46 ERA) to the mound in Game 2.

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San Francisco Giants vs Chicago Cubs Form

Table

Teams % P W L
5
Chicago Cubs
Chicago Cubs
0.611 36 22 14
5
San Francisco Giants
San Francisco Giants
0.611 36 22 14

San Francisco Giants and Chicago Cubs Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

May 4, 2025 - MLB

Colorado Rockies
3 :  9
San Francisco Giants

May 3, 2025 - MLB

Colorado Rockies
3 :  6
San Francisco Giants

May 2, 2025 - MLB

Colorado Rockies
0 :  4
San Francisco Giants

May 1, 2025 - MLB

Colorado Rockies
4 :  3
San Francisco Giants

Apr 30, 2025 - MLB

San Francisco Giants
3 :  5
San Diego Padres
L W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 4, 2025 - MLB

Colorado Rockies
3 :  9
San Francisco Giants

May 3, 2025 - MLB

Colorado Rockies
3 :  6
San Francisco Giants

May 2, 2025 - MLB

Colorado Rockies
0 :  4
San Francisco Giants

May 1, 2025 - MLB

Colorado Rockies
4 :  3
San Francisco Giants

Apr 27, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants

Apr 26, 2025 - MLB

Texas Rangers
2 :  3
San Francisco Giants
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

Apr 30, 2025 - MLB

San Francisco Giants
3 :  5
San Diego Padres

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Apr 20, 2025 - MLB

San Francisco Giants
4 :  5
Los Angeles Angels

Apr 19, 2025 - MLB

San Francisco Giants
3 :  2
Los Angeles Angels

Apr 18, 2025 - MLB

San Francisco Giants
0 :  2
Los Angeles Angels
Chicago Cubs
Chicago Cubs Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

May 4, 2025 - MLB

Chicago Cubs
0 :  4
Milwaukee Brewers

May 3, 2025 - MLB

Chicago Cubs
6 :  2
Milwaukee Brewers

May 2, 2025 - MLB

Chicago Cubs
10 :  0
Milwaukee Brewers

May 1, 2025 - MLB

Chicago Cubs
8 :  3
Pittsburgh Pirates

Apr 30, 2025 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

Apr 27, 2025 - MLB

Philadelphia Phillies
3 :  1
Chicago Cubs

Apr 26, 2025 - MLB

Philadelphia Phillies
10 :  4
Chicago Cubs

Apr 25, 2025 - MLB

Philadelphia Phillies
0 :  4
Chicago Cubs

Apr 23, 2025 - MLB

Los Angeles Dodgers
6 :  7
Chicago Cubs

Apr 22, 2025 - MLB

Los Angeles Dodgers
10 :  11
Chicago Cubs
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 4, 2025 - MLB

Chicago Cubs
0 :  4
Milwaukee Brewers

May 3, 2025 - MLB

Chicago Cubs
6 :  2
Milwaukee Brewers

May 2, 2025 - MLB

Chicago Cubs
10 :  0
Milwaukee Brewers

May 1, 2025 - MLB

Chicago Cubs
8 :  3
Pittsburgh Pirates

Apr 30, 2025 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates

Apr 29, 2025 - MLB

Chicago Cubs
9 :  0
Pittsburgh Pirates

San Francisco Giants against Chicago Cubs : Head to Head (H2H)

San Francisco Giants

67 %

Chicago Cubs

33 %

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

Mar 9, 2025 - MLB Spring Training

San Francisco Giants
8 :  6
Chicago Cubs

Feb 26, 2025 - MLB Spring Training

Chicago Cubs
4 :  4
San Francisco Giants

Jun 27, 2024 - MLB

Chicago Cubs
5 :  3
San Francisco Giants

Jun 26, 2024 - MLB

Chicago Cubs
3 :  4
San Francisco Giants

Jun 25, 2024 - MLB

Chicago Cubs
1 :  5
San Francisco Giants

San Francisco Giants - Chicago Cubs Key Points

  1. San Francisco is 1-6 SU in its last 7 games on the road.
  2. San Francisco is 1-6 SU in its last 7 games when playing on the road against Chicago Cubs.
  3. Chicago Cubs is 4-1 SU in its last 5 games.
  4. Chicago Cubs is 6-1 SU in its last 7 games when playing at home against San Francisco.
Up to $250 to bet on San Francisco Giants - Chicago Cubs! 

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Our San Francisco Giants vs Chicago Cubs Prediction

Fearless Forecast: Cubs’ offense stays hot, beats the Giants again

On Tuesday, we have a terrific matchup on the mound when Colin Rea duels with former CY Young Winner Justin Verlander (1-4, 3.94 ERA). After a slow start to his Giants stint, Verlander has slowly stabilized his numbers, giving up just 4 earned runs across 3 games. Unfortunately, the Giants have gone 0-4 in his last four starts. On the other hand, Rea has powered the Cubs to a victory in his last four trips on the mound. The Cubs have also won by at least two runs in these wins, which bodes well for bettors who picked Chicago to beat the -1.5 run handicap. Our betting prediction for Chicago Cubs vs. San Francisco Giants: Cubs -1.5 Runs

Prediction:

 

Cubs -1.5 Runs

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San Francisco Giants vs Chicago Cubs Picks
Up to $250 to bet on San Francisco Giants - Chicago Cubs! 

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