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by Lou Aguila in MLB Picks
The San Francisco Giants will go for an equalizer as they attempt to recover from an embarrassing series-opening loss to the Chicago Cubs in Tuesday’s Game 2 at Wrigley Field.
The Giants absorbed a huge 2-9 loss to the Cubs in Game 1 of their series. San Francisco, 12th in the MLB with 166 runs, could only score two runs as the Cubs hurler completely smothered them from start to finish. With the loss, the Giants’ record dropped to 22-14, third in the NL West standings.
The Cubs reinforced their position atop the NL Central with the win on Tuesday. Chicago is currently the No.1 scoring team in the MLB, averaging 6.1 runs per game on a .263 batting average this season. The Cubs are mid in terms of pitching, but they will be sending probably their most consistent pitcher this season in Colin Rea (2-0, 1.46 ERA) to the mound in Game 2.
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San Francisco Giants vs Chicago Cubs Form
Table
Teams | % | P | W | L |
---|---|---|---|---|
5
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0.611 | 36 | 22 | 14 |
5
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0.611 | 36 | 22 | 14 |
San Francisco Giants and Chicago Cubs Latest Matches

3/6 (50%)
3/6 (50%)
May 5, 2025 - MLB
May 4, 2025 - MLB
May 3, 2025 - MLB
May 2, 2025 - MLB
May 1, 2025 - MLB
Apr 30, 2025 - MLB
5/6 (83%)
1/6 (17%)
May 4, 2025 - MLB
May 3, 2025 - MLB
May 2, 2025 - MLB
May 1, 2025 - MLB
Apr 27, 2025 - MLB
Apr 26, 2025 - MLB
1/6 (17%)
5/6 (83%)
May 5, 2025 - MLB
Apr 30, 2025 - MLB
Apr 29, 2025 - MLB
Apr 20, 2025 - MLB
Apr 19, 2025 - MLB
Apr 18, 2025 - MLB

4/6 (67%)
2/6 (33%)
May 5, 2025 - MLB
May 4, 2025 - MLB
May 3, 2025 - MLB
May 2, 2025 - MLB
May 1, 2025 - MLB
Apr 30, 2025 - MLB
4/6 (67%)
2/6 (33%)
May 5, 2025 - MLB
Apr 27, 2025 - MLB
Apr 26, 2025 - MLB
Apr 25, 2025 - MLB
Apr 23, 2025 - MLB
Apr 22, 2025 - MLB
4/6 (67%)
2/6 (33%)
May 4, 2025 - MLB
May 3, 2025 - MLB
May 2, 2025 - MLB
May 1, 2025 - MLB
Apr 30, 2025 - MLB
Apr 29, 2025 - MLB
San Francisco Giants against Chicago Cubs : Head to Head (H2H)
67 %
33 %
May 5, 2025 - MLB
Mar 9, 2025 - MLB Spring Training
Feb 26, 2025 - MLB Spring Training
Jun 27, 2024 - MLB
Jun 26, 2024 - MLB
Jun 25, 2024 - MLB
San Francisco Giants - Chicago Cubs Key Points
- San Francisco is 1-6 SU in its last 7 games on the road.
- San Francisco is 1-6 SU in its last 7 games when playing on the road against Chicago Cubs.
- Chicago Cubs is 4-1 SU in its last 5 games.
- Chicago Cubs is 6-1 SU in its last 7 games when playing at home against San Francisco.
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Our San Francisco Giants vs Chicago Cubs Prediction
Fearless Forecast: Cubs’ offense stays hot, beats the Giants again
On Tuesday, we have a terrific matchup on the mound when Colin Rea duels with former CY Young Winner Justin Verlander (1-4, 3.94 ERA). After a slow start to his Giants stint, Verlander has slowly stabilized his numbers, giving up just 4 earned runs across 3 games. Unfortunately, the Giants have gone 0-4 in his last four starts. On the other hand, Rea has powered the Cubs to a victory in his last four trips on the mound. The Cubs have also won by at least two runs in these wins, which bodes well for bettors who picked Chicago to beat the -1.5 run handicap. Our betting prediction for Chicago Cubs vs. San Francisco Giants: Cubs -1.5 Runs
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