Tampa Bay Buccaneers vs San Francisco 49ers Prediction & Picks - NFL

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Tampa Bay Buccaneers
10/12/25 16:25
San Francisco 49ers

Prediction:

 

Tampa to win by 1-6 points

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 by Simon Day | in NFL Picks

The 4-1 San Francisco 49ers visit the 4-1 Tampa Bay Buccaneers in one of the standout Week 6 fixtures in the NFL. 

The Bucs recorded a thrilling 38-35 win in Seattle last week, thanks to another MVP calible game from QB Baker Mayfield and a late field goal from the in-form Chase McLaughlin. That victory was Tampa's fourth one-score success of the campaign and means they have already opened up a two game lead in the NFC South standings. 

San Francisco were also on the right end of a Week 5 thriller, as an overtime FG from Eddy Pineiro gave them a precious divisional victory over the LA Rams. Amazingly, like the Bucs, all of the Niners four wins this season have been in one-score contests. 

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Tampa Bay Buccaneers vs San Francisco 49ers Form

Table

Teams Pts P W L
7 San Francisco 49ers
0.706 17 12 5
16 Tampa Bay Buccaneers
0.471 17 8 9

Tampa Bay Buccaneers and San Francisco 49ers Latest Matches

Tampa Bay Buccaneers
Tampa Bay Buccaneers Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 5, 2025 - NFL

Seattle Seahawks
35 :  38
Tampa Bay Buccaneers

Sep 28, 2025 - NFL

Tampa Bay Buccaneers
25 :  31
Philadelphia Eagles

Sep 21, 2025 - NFL

Tampa Bay Buccaneers
29 :  27
New York Jets

Sep 15, 2025 - NFL

Houston Texans
19 :  20
Tampa Bay Buccaneers

Sep 7, 2025 - NFL

Atlanta Falcons
20 :  23
Tampa Bay Buccaneers

Jan 12, 2025 - NFL

Tampa Bay Buccaneers
20 :  23
Washington Commanders
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

Tampa Bay Buccaneers
25 :  31
Philadelphia Eagles

Sep 21, 2025 - NFL

Tampa Bay Buccaneers
29 :  27
New York Jets

Jan 12, 2025 - NFL

Tampa Bay Buccaneers
20 :  23
Washington Commanders

Jan 5, 2025 - NFL

Tampa Bay Buccaneers
27 :  19
New Orleans Saints

Dec 29, 2024 - NFL

Tampa Bay Buccaneers
48 :  14
Carolina Panthers

Dec 8, 2024 - NFL

Tampa Bay Buccaneers
28 :  13
Las Vegas Raiders
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 5, 2025 - NFL

Seattle Seahawks
35 :  38
Tampa Bay Buccaneers

Sep 15, 2025 - NFL

Houston Texans
19 :  20
Tampa Bay Buccaneers

Sep 7, 2025 - NFL

Atlanta Falcons
20 :  23
Tampa Bay Buccaneers

Dec 22, 2024 - NFL

Dallas Cowboys
26 :  24
Tampa Bay Buccaneers

Dec 15, 2024 - NFL

Los Angeles Chargers
17 :  40
Tampa Bay Buccaneers

Nov 24, 2024 - NFL

New York Giants
7 :  30
Tampa Bay Buccaneers
San Francisco 49ers
San Francisco 49ers Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 2, 2025 - NFL

Los Angeles Rams
23 :  26
San Francisco 49ers

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 1, 2024 - NFL

Buffalo Bills
35 :  10
San Francisco 49ers

Tampa Bay Buccaneers against San Francisco 49ers : Head to Head (H2H)

Tampa Bay Buccaneers

0 %

San Francisco 49ers

100 %

Nov 10, 2024 - NFL

Tampa Bay Buccaneers
20 :  23
San Francisco 49ers

Nov 19, 2023 - NFL

San Francisco 49ers
27 :  14
Tampa Bay Buccaneers

Dec 11, 2022 - NFL

San Francisco 49ers
35 :  7
Tampa Bay Buccaneers

Tampa Bay Buccaneers - San Francisco 49ers Key Points

  1. All 5 of the Bucs' games this season have been decided by 1-6 points
  2. The Bucs have won 6 of their last 7 regular season games
  3. All 5 of the Niners' games this season have been decided by 1-6 points
  4. San Fran have a point differential of -1 over the last 3 weeks
Up to $250 to bet on Tampa Bay Buccaneers - San Francisco 49ers! 

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Our Tampa Bay Buccaneers vs San Francisco 49ers Prediction

This looks set to be a thrilling and extremely close contest between two of the strongest teams in the NFC. 

The Niners have done remarkably well to reach 4-1, despite battling an ever-growing injury crisis that has deprived them of several regular starters in the opening weeks of the season. 

However, we are going to side with the Bucs in this one. QB Baker Mayfield is enjoying a stellar season, rookie WR Emeka Egbuka already looks like an elite NFL receiver and Rachaad White is doing an excellent job manning the Tampa running game in the absence of Bucky Irving. 

Our prediction for Tampa Bay Buccaneers vs San Francisco 49ers is: Tampa to win by 1-6 points. 

Prediction:

 

Tampa to win by 1-6 points

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Tampa Bay Buccaneers vs San Francisco 49ers Picks