Los Angeles Rams vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Los Angeles Rams
10/2/25 20:15
San Francisco 49ers

Prediction:

 

Los Angeles Rams ML

-245
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 by Matt Lowrimore | in NFL Picks

Week 5 of the NFL will kick off on Thursday night with an NFC West rivalry between the Los Angeles Rams and the San Francisco 49ers. Let’s take a look at the match statistics and predictions for this game between the Rams and the 49ers.

San Francisco enters this game with a record of 3-1, having most recently lost to the Jacksonville Jaguars in Week 4 by a score of 26-21. The 49ers’ offense had a total of 389 yards, while its defense allowed 325 yards. Quarterback Brock Purdy threw for 309 yards, two touchdowns, and two interceptions, while running back Christian McCaffrey led the team in rushing with 49 yards and receiving with 92 yards, with one touchdown.

As for Los Angeles, they also enter this game with a record of 3-1, having most recently beaten the Indianapolis Colts by a score of 27-20. The Rams’ offense had a total of 462 yards, while its defense allowed 333 yards. Quarterback Matthew Stafford threw for 375 yards and three touchdowns, while running back Kyren Williams led the team in rushing with 77 yards.

Los Angeles Rams vs San Francisco 49ers Form

Table

Teams Pts P W L
5 Los Angeles Rams
0.706 17 12 5
7 San Francisco 49ers
0.706 17 12 5

Los Angeles Rams and San Francisco 49ers Latest Matches

Los Angeles Rams
Los Angeles Rams Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

Los Angeles Rams
27 :  20
Indianapolis Colts

Sep 21, 2025 - NFL

Philadelphia Eagles
33 :  26
Los Angeles Rams

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 28, 2025 - NFL

Los Angeles Rams
27 :  20
Indianapolis Colts

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 8, 2024 - NFL

Los Angeles Rams
44 :  42
Buffalo Bills
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Philadelphia Eagles
33 :  26
Los Angeles Rams

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Dec 22, 2024 - NFL

New York Jets
9 :  19
Los Angeles Rams

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Nov 17, 2024 - NFL

New England Patriots
22 :  28
Los Angeles Rams
San Francisco 49ers
San Francisco 49ers Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

Seattle Seahawks
13 :  17
San Francisco 49ers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 1, 2024 - NFL

Buffalo Bills
35 :  10
San Francisco 49ers

Nov 24, 2024 - NFL

Green Bay Packers
38 :  10
San Francisco 49ers

Los Angeles Rams against San Francisco 49ers : Head to Head (H2H)

Los Angeles Rams

50 %

San Francisco 49ers

50 %

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Sep 22, 2024 - NFL

Los Angeles Rams
27 :  24
San Francisco 49ers

Jan 7, 2024 - NFL

San Francisco 49ers
20 :  21
Los Angeles Rams

Sep 17, 2023 - NFL

Los Angeles Rams
23 :  30
San Francisco 49ers

Oct 30, 2022 - NFL

Los Angeles Rams
14 :  31
San Francisco 49ers

Oct 3, 2022 - NFL

San Francisco 49ers
24 :  9
Los Angeles Rams

Los Angeles Rams - San Francisco 49ers Key Points

  1. The 49ers are 2-2 ATS this season
  2. The Rams are 3-1 ATS this season
  3. The 49ers are averaging 20.0 points per game this season
  4. The Rams are averaging 25.0 points per game this season

Our Los Angeles Rams vs San Francisco 49ers Prediction

The Rams are a decent-sized favorite in this game, but still look to be the best betting option. Los Angeles’ offense has been far superior to that of San Francisco, as the Rams are averaging 25 points per game, compared to the 49ers, who are averaging 20 points per game.

More specifically, Rams quarterback Matthew Stafford has already thrown for 1,114 yards this season, eight touchdowns, and just two interceptions. As for the 49ers, their quarterback, Brock Purdy, has been mediocre at best and is still dealing with an injury that has him questionable for this game. 

Even if Purdy is cleared for Thursday’s game, the Rams' offensive firepower cannot be underestimated. For that reason, our Los Angeles Rams vs San Francisco 49ers prediction is: Los Angeles Rams ML.

Prediction:

 

Los Angeles Rams ML

-245
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Rams vs San Francisco 49ers Picks