Arizona Cardinals vs San Francisco 49ers Prediction & Picks - NFL

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Arizona Cardinals
1/5/25 16:25
San Francisco 49ers

Prediction:

 

49ers ML

+180
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 by Travis Pulver | in NFL Picks

The San Francisco 49er will close out a disappointing season with a trip to Arizona to take on the Cardinals at State Farm Stadium in Glendale. Kickoff is scheduled for 4:25 p.m. ET. With both teams already eliminated from the postseason, both teams will be looking to end the season on a positive note after stumbling down the stretch.

Arizona will have more of their regular players available for the game, but the 49ers may be a little more motivated to bring their ‘A’ game. Jauan Jennings is 77 yards short of his first 1,000-yard season. After missing much of his rookie season recovering from a gunshot wound, he’s probably eager to show the team and fans what he’s capable of.

But the 49ers will not have Brock Purdy available as he recovers from an elbow injury. While Brandon Allen got the start earlier in the season when Purdy couldn’t go, Joshua Dobbs will start this week. Joshua Dobbs is the more athletic of the two and could give the offense an added dimension. Since he’s on a one-year contract, a solid performance in this game could go a long way to making sure he makes a roster next season.

Arizona Cardinals vs San Francisco 49ers Form

Table

Teams Pts P W L
17 Arizona Cardinals
0.471 17 8 9
22 San Francisco 49ers
0.353 17 6 11

Arizona Cardinals and San Francisco 49ers Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Dec 1, 2024 - NFL

Minnesota Vikings
23 :  22
Arizona Cardinals

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 10, 2024 - NFL

Arizona Cardinals
31 :  6
New York Jets

Nov 3, 2024 - NFL

Arizona Cardinals
29 :  9
Chicago Bears

Oct 21, 2024 - NFL

Arizona Cardinals
17 :  15
Los Angeles Chargers

Sep 29, 2024 - NFL

Arizona Cardinals
14 :  42
Washington Commanders
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 1, 2024 - NFL

Minnesota Vikings
23 :  22
Arizona Cardinals

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals

Oct 27, 2024 - NFL

Miami Dolphins
27 :  28
Arizona Cardinals

Oct 13, 2024 - NFL

Green Bay Packers
34 :  13
Arizona Cardinals
San Francisco 49ers
San Francisco 49ers Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Dec 1, 2024 - NFL

Buffalo Bills
35 :  10
San Francisco 49ers

Nov 24, 2024 - NFL

Green Bay Packers
38 :  10
San Francisco 49ers
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 30, 2024 - NFL

San Francisco 49ers
34 :  40
Detroit Lions

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Dec 8, 2024 - NFL

San Francisco 49ers
38 :  13
Chicago Bears

Nov 17, 2024 - NFL

San Francisco 49ers
17 :  20
Seattle Seahawks

Oct 27, 2024 - NFL

San Francisco 49ers
30 :  24
Dallas Cowboys

Oct 20, 2024 - NFL

San Francisco 49ers
18 :  28
Kansas City Chiefs
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 1, 2024 - NFL

Buffalo Bills
35 :  10
San Francisco 49ers

Nov 24, 2024 - NFL

Green Bay Packers
38 :  10
San Francisco 49ers

Nov 10, 2024 - NFL

Tampa Bay Buccaneers
20 :  23
San Francisco 49ers

Oct 10, 2024 - NFL

Seattle Seahawks
24 :  36
San Francisco 49ers

Sep 22, 2024 - NFL

Los Angeles Rams
27 :  24
San Francisco 49ers

Arizona Cardinals against San Francisco 49ers : Head to Head (H2H)

Arizona Cardinals

25 %

San Francisco 49ers

75 %

Oct 6, 2024 - NFL

San Francisco 49ers
23 :  24
Arizona Cardinals

Dec 17, 2023 - NFL

Arizona Cardinals
29 :  45
San Francisco 49ers

Oct 1, 2023 - NFL

San Francisco 49ers
35 :  16
Arizona Cardinals

Nov 21, 2022 - NFL

Arizona Cardinals
10 :  38
San Francisco 49ers

Arizona Cardinals - San Francisco 49ers Key Points

  1. San Francisco has lost five of their last seven, while the Cardinals have lost six of their last seven
  2. The 49ers lead the all-time series vs. the Cardinals 36-30; San Francisco has won six of the last ten.
  3. Arizona has not defeated the 49ers at home since the 2021 season.
  4. The OVER is 7-8-1 for Arizona this season and 9-7 for San Francisco.

Our Arizona Cardinals vs San Francisco 49ers Prediction

The Cardinals should be the betting favorite simply because Kyler Murray is playing and Brock Purdy isn’t. However, Murray hasn’t exactly been lighting up opposing secondaries in recent weeks. Yes, he had 300+ yards against the Rams last week, but he also had two picks and only scored nine points. Joshua Dobbs’ athleticism could give the offense the spark it needs to close the season with a win. With the potential Dobbs, Jennings, and Pearsall have for big performances in this game, we see the San Francisco ML as having a lot of value.

Our 49ers vs. Cardinals Prediction: 49ers ML

Prediction:

 

49ers ML

+180
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Arizona Cardinals vs San Francisco 49ers Picks