San Diego Padres vs Seattle Mariners Prediction & Picks - MLB

See our betting tips for the next match between these two teams
San Diego Padres - Seattle Mariners Betting tips

USA - MLB

San Diego Padres
8/25/25 21:40
Seattle Mariners

Prediction:

 

The Mariners -1.5 Runs

+161
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 by Lou Aguila in MLB Picks

Pegged at -126 on DraftKings, the Seattle Mariners target their fifth consecutive win over the San Diego Padres in Monday’s series opener at T-Mobile Park.

The Mariners have narrowed the gap that separates them from the Houston Astros to two games after taking 2 out of 3 games in the just-concluded series with the Athletics. Seattle, boasting a 3.95 ERA in the season, displayed exceptional pitching throughout the series, giving up only eight runs against an above-average offensive team like the Athletics. The Mariners then saved the best for last as MVP contender Cal Raleigh belted two home runs to power the Mariners to an 11-2 win in the series finale. Raleigh finished the game with four RBIs, while Julio Rodrigue and Victor Robles chipped in two RBIs each.

The Padres failed to complete a three-game sweep of the Los Angeles Dodgers after dropping Game 3 2-8. After stifling the Dodgers to one run in Games 1 and 2, San Diego conceded four home runs in the series finale, two of which came from reigning World Series MVP Freddie Freeman. With the loss, the Padres missed the opportunity to enter a new week as the No.1 team in the NL West. Instead, they found themselves in a two-way tie with the Dodgers with an identical 74-57 record.

San Diego Padres vs Seattle Mariners Form

Table

Teams % P W L
7
San Diego Padres
San Diego Padres
0.564 133 75 58
12
Seattle Mariners
Seattle Mariners
0.534 133 71 62

San Diego Padres and Seattle Mariners Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 24, 2025 - MLB

Los Angeles Dodgers
8 :  2
San Diego Padres

Aug 23, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Aug 22, 2025 - MLB

Los Angeles Dodgers
1 :  2
San Diego Padres

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 24, 2025 - MLB

Los Angeles Dodgers
8 :  2
San Diego Padres

Aug 23, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Aug 22, 2025 - MLB

Los Angeles Dodgers
1 :  2
San Diego Padres

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants

Aug 11, 2025 - MLB

San Diego Padres
4 :  1
San Francisco Giants
Seattle Mariners
Seattle Mariners Latest matches
L L L W W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 24, 2025 - MLB

Athletics
4 :  11
Seattle Mariners

Aug 23, 2025 - MLB

Athletics
2 :  1
Seattle Mariners

Aug 22, 2025 - MLB

Athletics
2 :  3
Seattle Mariners

Aug 20, 2025 - MLB

Seattle Mariners
2 :  11
Philadelphia Phillies

Aug 19, 2025 - MLB

Seattle Mariners
4 :  6
Philadelphia Phillies

Aug 18, 2025 - MLB

Seattle Mariners
7 :  12
Philadelphia Phillies
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 24, 2025 - MLB

Athletics
4 :  11
Seattle Mariners

Aug 23, 2025 - MLB

Athletics
2 :  1
Seattle Mariners

Aug 22, 2025 - MLB

Athletics
2 :  3
Seattle Mariners

Aug 10, 2025 - MLB

Tampa Bay Rays
3 :  6
Seattle Mariners

Aug 9, 2025 - MLB

Tampa Bay Rays
4 :  7
Seattle Mariners

Aug 8, 2025 - MLB

Tampa Bay Rays
2 :  3
Seattle Mariners
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Seattle Mariners
2 :  11
Philadelphia Phillies

Aug 19, 2025 - MLB

Seattle Mariners
4 :  6
Philadelphia Phillies

Aug 18, 2025 - MLB

Seattle Mariners
7 :  12
Philadelphia Phillies

Aug 17, 2025 - MLB

Seattle Mariners
3 :  7
New York Mets

Aug 16, 2025 - MLB

Seattle Mariners
1 :  3
New York Mets

Aug 15, 2025 - MLB

Seattle Mariners
11 :  9
New York Mets

San Diego Padres against Seattle Mariners : Head to Head (H2H)

San Diego Padres

33 %

Seattle Mariners

67 %

May 18, 2025 - MLB

Seattle Mariners
6 :  1
San Diego Padres

May 17, 2025 - MLB

Seattle Mariners
4 :  1
San Diego Padres

May 16, 2025 - MLB

Seattle Mariners
5 :  1
San Diego Padres

Mar 24, 2025 - MLB Spring Training

Seattle Mariners
7 :  7
San Diego Padres

Mar 15, 2025 - MLB Spring Training

San Diego Padres
8 :  3
Seattle Mariners

Feb 28, 2025 - MLB Spring Training

Seattle Mariners
2 :  1
San Diego Padres

San Diego Padres - Seattle Mariners Key Points

  1. Seattle is 9-1 SU in its last 10 games at home.
  2. Seattle is 4-1 SU in its last 5 games when playing at home against San Diego.
  3. San Diego is 5-1 SU in its last 6 games.
  4. San Diego is 1-8 SU in its last 9 games against Seattle.

Our San Diego Padres vs Seattle Mariners Prediction

I am backing the Mariners to cover -1.5 runs in this series opener. Seattle has the Padres’ numbers in their recent matchups, winning 8 of their last 10 head-to-head matches. Moreover, the Mariners won by at least two runs in each of those eight wins, which only means that Seattle knows how to play and win against the Padres (most of the time). Seattle will start Bryce Miller, who hasn’t been dependable as of late (7.43 ERA in his last five starts), though he blanked the Padres through five innings in his first and only faceoff against the team on July 10, 2024. Seattle won the game 2-0.

The Padres are dispatching JP Sears, who squandered five earned runs and 10 hits over five innings in his first game since ending up in San Diego via trade with the Athletics. Sears has given up an average of two earned runs over his last three face-offs with the Marines. I expect Sears to put up a better stint in his second start as a Padre. However, with San Diego averaging one earned run in their last three meetings against Seattle, the Padres' chances of winning this ballgame could be much lower than the 42 percent win probability handed to them by ESPN Match Predictor.

Our betting prediction for the San Diego Padres vs. the Seattle Mariners: the Mariners -1.5 Runs.

Prediction:

 

The Mariners -1.5 Runs

+161
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San Diego Padres vs Seattle Mariners Picks