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by Lou Aguila in MLB Picks
Pegged at -126 on DraftKings, the Seattle Mariners target their fifth consecutive win over the San Diego Padres in Monday’s series opener at T-Mobile Park.
The Mariners have narrowed the gap that separates them from the Houston Astros to two games after taking 2 out of 3 games in the just-concluded series with the Athletics. Seattle, boasting a 3.95 ERA in the season, displayed exceptional pitching throughout the series, giving up only eight runs against an above-average offensive team like the Athletics. The Mariners then saved the best for last as MVP contender Cal Raleigh belted two home runs to power the Mariners to an 11-2 win in the series finale. Raleigh finished the game with four RBIs, while Julio Rodrigue and Victor Robles chipped in two RBIs each.
The Padres failed to complete a three-game sweep of the Los Angeles Dodgers after dropping Game 3 2-8. After stifling the Dodgers to one run in Games 1 and 2, San Diego conceded four home runs in the series finale, two of which came from reigning World Series MVP Freddie Freeman. With the loss, the Padres missed the opportunity to enter a new week as the No.1 team in the NL West. Instead, they found themselves in a two-way tie with the Dodgers with an identical 74-57 record.
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San Diego Padres vs Seattle Mariners Form
Table
Teams | % | P | W | L |
---|---|---|---|---|
7
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0.564 | 133 | 75 | 58 |
12
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0.534 | 133 | 71 | 62 |
San Diego Padres and Seattle Mariners Latest Matches

5/6 (83%)
1/6 (17%)
Aug 24, 2025 - MLB
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5/6 (83%)
1/6 (17%)
Aug 24, 2025 - MLB
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3/6 (50%)
3/6 (50%)
Aug 17, 2025 - MLB
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Aug 11, 2025 - MLB

2/6 (33%)
4/6 (67%)
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
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Aug 18, 2025 - MLB
5/6 (83%)
1/6 (17%)
Aug 24, 2025 - MLB
Aug 23, 2025 - MLB
Aug 22, 2025 - MLB
Aug 10, 2025 - MLB
Aug 9, 2025 - MLB
Aug 8, 2025 - MLB
1/6 (17%)
5/6 (83%)
Aug 20, 2025 - MLB
Aug 19, 2025 - MLB
Aug 18, 2025 - MLB
Aug 17, 2025 - MLB
Aug 16, 2025 - MLB
Aug 15, 2025 - MLB
San Diego Padres against Seattle Mariners : Head to Head (H2H)
33 %
67 %
May 18, 2025 - MLB
May 17, 2025 - MLB
May 16, 2025 - MLB
Mar 24, 2025 - MLB Spring Training
Mar 15, 2025 - MLB Spring Training
Feb 28, 2025 - MLB Spring Training
San Diego Padres - Seattle Mariners Key Points
- Seattle is 9-1 SU in its last 10 games at home.
- Seattle is 4-1 SU in its last 5 games when playing at home against San Diego.
- San Diego is 5-1 SU in its last 6 games.
- San Diego is 1-8 SU in its last 9 games against Seattle.
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Our San Diego Padres vs Seattle Mariners Prediction
I am backing the Mariners to cover -1.5 runs in this series opener. Seattle has the Padres’ numbers in their recent matchups, winning 8 of their last 10 head-to-head matches. Moreover, the Mariners won by at least two runs in each of those eight wins, which only means that Seattle knows how to play and win against the Padres (most of the time). Seattle will start Bryce Miller, who hasn’t been dependable as of late (7.43 ERA in his last five starts), though he blanked the Padres through five innings in his first and only faceoff against the team on July 10, 2024. Seattle won the game 2-0.
The Padres are dispatching JP Sears, who squandered five earned runs and 10 hits over five innings in his first game since ending up in San Diego via trade with the Athletics. Sears has given up an average of two earned runs over his last three face-offs with the Marines. I expect Sears to put up a better stint in his second start as a Padre. However, with San Diego averaging one earned run in their last three meetings against Seattle, the Padres' chances of winning this ballgame could be much lower than the 42 percent win probability handed to them by ESPN Match Predictor.
Our betting prediction for the San Diego Padres vs. the Seattle Mariners: the Mariners -1.5 Runs.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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