San Diego Padres vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

San Diego Padres
6/5/25 15:45
San Francisco Giants

Prediction:

 

Under 7.5

-125
$300 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Carlos Zabala | in MLB Picks

The Padres took Game 1 and Game 2 in the San Francisco Bay Area, with Pivetta pitching. It was thought they also had a good chance of winning Game 3, but that proved not to be the case. The Giants won Game 3 6-5 with pregame odds of +101. They rallied to close out a 0-5 deficit, with the Padres leading in the top of the fifth inning. Pivetta had a good day early on, but it got worse when he got to the midway point, and the Giants' bats were able to figure him out. Chapman's 11th home run of the season got the Giants back in the game, and with a three-run home run in the bottom of the seventh inning, they sealed the final score at 6-5.

For Game 4 the Giants now seem to have the advantage in the pitching duel; until recently Robbie Ray had the best record for a pitcher in the MLB with 7-0, and he pitched very well in his last outing against the Marlins in Miami, where he threw 7 innings, struck out 9 and still ended up scoring his first L. Robbie Ray has 78 strikeouts with the Giants this season, the same number that Dylan Cease, who will start for the Padres, achieved, but with a worse record of 1-4.

San Diego Padres vs San Francisco Giants Form

Table

Teams % P W L
7
San Diego Padres
San Diego Padres
0.574 61 35 26
8
San Francisco Giants
San Francisco Giants
0.556 63 35 28

San Diego Padres and San Francisco Giants Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

Jun 3, 2025 - MLB

San Diego Padres
3 :  2
San Francisco Giants

Jun 2, 2025 - MLB

San Diego Padres
1 :  0
San Francisco Giants

Jun 1, 2025 - MLB

Pittsburgh Pirates
4 :  6
San Diego Padres

May 31, 2025 - MLB

Pittsburgh Pirates
5 :  0
San Diego Padres

May 30, 2025 - MLB

Pittsburgh Pirates
2 :  3
San Diego Padres
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 1, 2025 - MLB

Pittsburgh Pirates
4 :  6
San Diego Padres

May 31, 2025 - MLB

Pittsburgh Pirates
5 :  0
San Diego Padres

May 30, 2025 - MLB

Pittsburgh Pirates
2 :  3
San Diego Padres

May 28, 2025 - MLB

Miami Marlins
10 :  8
San Diego Padres

May 27, 2025 - MLB

Miami Marlins
6 :  8
San Diego Padres

May 26, 2025 - MLB

Miami Marlins
3 :  4
San Diego Padres
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

Jun 3, 2025 - MLB

San Diego Padres
3 :  2
San Francisco Giants

Jun 2, 2025 - MLB

San Diego Padres
1 :  0
San Francisco Giants

May 25, 2025 - MLB

San Diego Padres
5 :  3
Atlanta Braves

May 24, 2025 - MLB

San Diego Padres
1 :  7
Atlanta Braves

May 23, 2025 - MLB

San Diego Padres
2 :  1
Atlanta Braves
San Francisco Giants
San Francisco Giants Latest matches
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

Jun 3, 2025 - MLB

San Diego Padres
3 :  2
San Francisco Giants

Jun 2, 2025 - MLB

San Diego Padres
1 :  0
San Francisco Giants

Jun 1, 2025 - MLB

San Francisco Giants
4 :  2
Miami Marlins

May 31, 2025 - MLB

San Francisco Giants
0 :  1
Miami Marlins

May 30, 2025 - MLB

San Francisco Giants
2 :  0
Miami Marlins
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

Jun 3, 2025 - MLB

San Diego Padres
3 :  2
San Francisco Giants

Jun 2, 2025 - MLB

San Diego Padres
1 :  0
San Francisco Giants

May 21, 2025 - MLB

Kansas City Royals
8 :  4
San Francisco Giants

May 20, 2025 - MLB

Kansas City Royals
2 :  3
San Francisco Giants

May 19, 2025 - MLB

Kansas City Royals
3 :  1
San Francisco Giants
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 1, 2025 - MLB

San Francisco Giants
4 :  2
Miami Marlins

May 31, 2025 - MLB

San Francisco Giants
0 :  1
Miami Marlins

May 30, 2025 - MLB

San Francisco Giants
2 :  0
Miami Marlins

May 28, 2025 - MLB

San Francisco Giants
3 :  4
Detroit Tigers

May 27, 2025 - MLB

San Francisco Giants
1 :  3
Detroit Tigers

May 26, 2025 - MLB

San Francisco Giants
1 :  3
Detroit Tigers

San Diego Padres against San Francisco Giants : Head to Head (H2H)

San Diego Padres

67 %

San Francisco Giants

33 %

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants

Jun 3, 2025 - MLB

San Diego Padres
3 :  2
San Francisco Giants

Jun 2, 2025 - MLB

San Diego Padres
1 :  0
San Francisco Giants

Apr 30, 2025 - MLB

San Francisco Giants
3 :  5
San Diego Padres

Apr 29, 2025 - MLB

San Francisco Giants
4 :  7
San Diego Padres

Mar 18, 2025 - MLB Spring Training

San Diego Padres
3 :  4
San Francisco Giants

San Diego Padres - San Francisco Giants Key Points

  1. Giants pitching allows the fewest home runs in MLB
  2. Padres pitching BAA 5th best in MLB
  3. Padres won 8 of last 10 games against Giants
  4. Giants 16-9 record as betting favorites playing at Oracle Park

Our San Diego Padres vs San Francisco Giants Prediction

Cease didn't have a single outing in May where he didn't allow 2 runs or fewer; when he pitched against the Blue Jays in Toronto, he allowed 2 HRs. However, he did exceptionally well the last time he faced the Giants when he struck out 10, although that was in 2024. Ray and Cease, while neither is particularly dominant, if they are great strikeout pitchers and prove it again in 2025, it could be a low-run game. Our prediction for Padres vs Giants is: Under 7.5 runs.

Prediction:

 

Under 7.5

-125
$300 offered for betting!

Jackpot Pools

DK Jackpot Pools

DraftKings's long-running promo Jackpot Pools gives bettors a chance to win a whopping $10,000 which grows with every entry! 

To win, you'll need to answer all 15 questions correctly and the pool is yours! If there are multiple winners, the pool will be split. If no one wins, however, the jackpot rolls over to the next pool, increasing the winnings. You can enter up to 10 times each pool to give yourself an even greater chance of winning. Once the event has completed, you can collect your winnings within 24 hours so keep an eye on the pool! Don't miss out on your chance to win big and make your picks today!

Get started today!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

San Diego Padres vs San Francisco Giants Picks