San Diego Padres vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

San Diego Padres
8/29/25 20:10
Minnesota Twins

Prediction:

 

San Diego -1.5

+134
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 by Travis Pulver in MLB Picks

The Minnesota Twins will host the San Diego Padres in a three-game series at Target Field in Minneapolis this weekend. Game One is scheduled for tonight at 8:10 p.m. EST.

San Diego will look to turn things around after losing three of their last four, including two in Seattle. At 75-59, they are in comfortable control of one of three NL wildcard slots, but there is a lot of baseball left to be played. As for the Twins, this is their first game at home after a 2-4 road trip. Nestor Cortes is scheduled to start for the Padres. Cortes has a 2-2 record in six starts with a 4.66 ERA, 1.34 WHIP, and .224 OBA. However, he has struggled on the road, where he is 0-1 in three starts with an 8.74 ERA and .326 OBA. But since being acquired by San Diego, he is 1-1 in four starts with a 3.0 ERA. He one-hit the Dodgers his last time out (Aug. 23). As for the Twins, Zebby Mathews is scheduled to start. He has gone 3-4 this season in 11 starts with a 5.30 ERA, 1.52 WHIP, and .288 OBA. But he has been better at home, where he is 1-1 with a 4.42 ERA and .270 OBA.

San Diego Padres vs Minnesota Twins Form

Table

Teams % P W L
7
San Diego Padres
San Diego Padres
0.56 134 75 59
25
Minnesota Twins
Minnesota Twins
0.451 133 60 73

San Diego Padres and Minnesota Twins Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 27, 2025 - MLB

San Diego Padres
3 :  4
Seattle Mariners

Aug 26, 2025 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Aug 25, 2025 - MLB

San Diego Padres
6 :  9
Seattle Mariners

Aug 24, 2025 - MLB

Los Angeles Dodgers
8 :  2
San Diego Padres

Aug 23, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Aug 22, 2025 - MLB

Los Angeles Dodgers
1 :  2
San Diego Padres
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 24, 2025 - MLB

Los Angeles Dodgers
8 :  2
San Diego Padres

Aug 23, 2025 - MLB

Los Angeles Dodgers
1 :  5
San Diego Padres

Aug 22, 2025 - MLB

Los Angeles Dodgers
1 :  2
San Diego Padres

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 27, 2025 - MLB

San Diego Padres
3 :  4
Seattle Mariners

Aug 26, 2025 - MLB

San Diego Padres
7 :  6
Seattle Mariners

Aug 25, 2025 - MLB

San Diego Padres
6 :  9
Seattle Mariners

Aug 17, 2025 - MLB

San Diego Padres
4 :  5
Los Angeles Dodgers

Aug 16, 2025 - MLB

San Diego Padres
0 :  6
Los Angeles Dodgers

Aug 15, 2025 - MLB

San Diego Padres
2 :  3
Los Angeles Dodgers
Minnesota Twins
Minnesota Twins Latest matches
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 27, 2025 - MLB

Minnesota Twins
8 :  9
Toronto Blue Jays

Aug 26, 2025 - MLB

Minnesota Twins
7 :  5
Toronto Blue Jays

Aug 25, 2025 - MLB

Minnesota Twins
4 :  10
Toronto Blue Jays

Aug 24, 2025 - MLB

Minnesota Twins
0 :  8
Chicago White Sox

Aug 23, 2025 - MLB

Minnesota Twins
3 :  7
Chicago White Sox

Aug 22, 2025 - MLB

Minnesota Twins
9 :  7
Chicago White Sox
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 21, 2025 - MLB

Athletics
8 :  3
Minnesota Twins

Aug 20, 2025 - MLB

Athletics
4 :  2
Minnesota Twins

Aug 19, 2025 - MLB

Athletics
6 :  3
Minnesota Twins

Aug 17, 2025 - MLB

Detroit Tigers
1 :  8
Minnesota Twins

Aug 16, 2025 - MLB

Detroit Tigers
8 :  5
Minnesota Twins

Aug 15, 2025 - MLB

Detroit Tigers
7 :  0
Minnesota Twins
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 27, 2025 - MLB

Minnesota Twins
8 :  9
Toronto Blue Jays

Aug 26, 2025 - MLB

Minnesota Twins
7 :  5
Toronto Blue Jays

Aug 25, 2025 - MLB

Minnesota Twins
4 :  10
Toronto Blue Jays

Aug 24, 2025 - MLB

Minnesota Twins
0 :  8
Chicago White Sox

Aug 23, 2025 - MLB

Minnesota Twins
3 :  7
Chicago White Sox

Aug 22, 2025 - MLB

Minnesota Twins
9 :  7
Chicago White Sox

San Diego Padres against Minnesota Twins : Head to Head (H2H)

San Diego Padres

67 %

Minnesota Twins

33 %

Aug 21, 2024 - MLB

Minnesota Twins
11 :  4
San Diego Padres

Aug 20, 2024 - MLB

Minnesota Twins
5 :  7
San Diego Padres

Aug 19, 2024 - MLB

Minnesota Twins
3 :  5
San Diego Padres

San Diego Padres - Minnesota Twins Key Points

  1. Minnesota leads the all-time series vs. San Diego 19-10.
  2. San Diego is 23-15 since the All-Star break with a +47-run differential; Minnesota is 13-24 (worst record since the break) with a -54-run differential.
  3. The OVER is 57-73-4 for the Padres and 60-67-6 for the Twins.
  4. Betting Public: 79% of moneyline tickets and 91% of the handle are on the Padres.

Our San Diego Padres vs Minnesota Twins Prediction

The numbers for Nestor Cortes paint an unimpressive picture of him, primarily because he got thrashed by the Yankees in his first outing of the year (March 29), giving up six hits (five home runs) and eight runs in two innings of work. He looked good in his only other appearance before the trade (April 3 vs. Cincinnati) and has done a good job for the Padres. It would be nice to get a little more help from the lineup today (.232 BA over the last week). But facing Mathews may be just what the San Diego lineup needs.

Our Padres vs. Twins Pick: San Diego -1.5

Prediction:

 

San Diego -1.5

+134
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San Diego Padres vs Minnesota Twins Picks