San Diego Padres vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Diego Padres
9/30/25 15:08
Chicago Cubs

Prediction:

 

Chicago Cubs wins the match

-116
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 by Tyler Doty in MLB Picks

The Major League Baseball playoffs are underway, and the first game will be played at Wrigley Field, with the Chicago Cubs taking on the San Diego Padres.

 This stage is also known as the Wild Card Series, which is a best-of-three series, with the winner advancing to the Division Series of their respective league. 

The Cubs finished second in the National League Central Division with 92 wins and 70 losses, giving them a 56% winning percentage and a 5.0 percentage point lead over the Brewers, who advanced directly.  

Meanwhile, the San Diego Padres finished second in the National League West Division with 90 wins and 72 losses, giving them a 55% winning percentage. They also have a 3.0 percentage point lead over the Dodgers.

San Diego Padres vs Chicago Cubs Form

San Diego Padres and Chicago Cubs Latest Matches

San Diego Padres
San Diego Padres Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 28, 2025 - MLB

Arizona Diamondbacks
4 :  12
San Diego Padres

Sep 27, 2025 - MLB

Arizona Diamondbacks
1 :  5
San Diego Padres

Sep 26, 2025 - MLB

Arizona Diamondbacks
4 :  7
San Diego Padres

Sep 24, 2025 - MLB

Milwaukee Brewers
3 :  1
San Diego Padres

Sep 23, 2025 - MLB

Milwaukee Brewers
0 :  7
San Diego Padres

Sep 22, 2025 - MLB

Milwaukee Brewers
4 :  5
San Diego Padres
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 28, 2025 - MLB

Arizona Diamondbacks
4 :  12
San Diego Padres

Sep 27, 2025 - MLB

Arizona Diamondbacks
1 :  5
San Diego Padres

Sep 26, 2025 - MLB

Arizona Diamondbacks
4 :  7
San Diego Padres

Sep 24, 2025 - MLB

Milwaukee Brewers
3 :  1
San Diego Padres

Sep 23, 2025 - MLB

Milwaukee Brewers
0 :  7
San Diego Padres

Sep 22, 2025 - MLB

Milwaukee Brewers
4 :  5
San Diego Padres
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - MLB

San Diego Padres
3 :  2
Chicago White Sox

Sep 20, 2025 - MLB

San Diego Padres
7 :  3
Chicago White Sox

Sep 19, 2025 - MLB

San Diego Padres
3 :  4
Chicago White Sox

Sep 18, 2025 - MLB

San Diego Padres
1 :  6
New York Mets

Sep 17, 2025 - MLB

San Diego Padres
7 :  4
New York Mets

Sep 16, 2025 - MLB

San Diego Padres
3 :  8
New York Mets
Chicago Cubs
Chicago Cubs Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 28, 2025 - MLB

St. Louis Cardinals
0 :  2
Chicago Cubs

Sep 27, 2025 - MLB

St. Louis Cardinals
3 :  7
Chicago Cubs

Sep 26, 2025 - MLB

St. Louis Cardinals
1 :  12
Chicago Cubs

Sep 25, 2025 - MLB

New York Mets
8 :  5
Chicago Cubs

Sep 24, 2025 - MLB

New York Mets
3 :  10
Chicago Cubs

Sep 23, 2025 - MLB

New York Mets
9 :  7
Chicago Cubs
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 28, 2025 - MLB

St. Louis Cardinals
0 :  2
Chicago Cubs

Sep 27, 2025 - MLB

St. Louis Cardinals
3 :  7
Chicago Cubs

Sep 26, 2025 - MLB

St. Louis Cardinals
1 :  12
Chicago Cubs

Sep 25, 2025 - MLB

New York Mets
8 :  5
Chicago Cubs

Sep 24, 2025 - MLB

New York Mets
3 :  10
Chicago Cubs

Sep 23, 2025 - MLB

New York Mets
9 :  7
Chicago Cubs
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 21, 2025 - MLB

Chicago Cubs
0 :  1
Cincinnati Reds

Sep 20, 2025 - MLB

Chicago Cubs
3 :  6
Cincinnati Reds

Sep 19, 2025 - MLB

Chicago Cubs
4 :  7
Cincinnati Reds

Sep 18, 2025 - MLB

Chicago Cubs
0 :  1
Cincinnati Reds

Sep 17, 2025 - MLB

Chicago Cubs
8 :  4
Pittsburgh Pirates

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

San Diego Padres against Chicago Cubs : Head to Head (H2H)

San Diego Padres

50 %

Chicago Cubs

50 %

Apr 16, 2025 - MLB

Chicago Cubs
2 :  4
San Diego Padres

Apr 15, 2025 - MLB

Chicago Cubs
2 :  1
San Diego Padres

Apr 14, 2025 - MLB

Chicago Cubs
4 :  10
San Diego Padres

Apr 6, 2025 - MLB

San Diego Padres
8 :  7
Chicago Cubs

Apr 5, 2025 - MLB

San Diego Padres
1 :  7
Chicago Cubs

Apr 4, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

San Diego Padres - Chicago Cubs Key Points

  1. The Cubs are 4-6 in their last 10.
  2. The Cubs have 50 wins and 31 losses at home.
  3. In their last 10 games, the Padres have seven wins and three losses.
  4. The San Diego Padres have 38 wins and 43 losses on the road.

Our San Diego Padres vs Chicago Cubs Prediction

It is a fact that the Cubs team has long been unable to deliver a resounding victory to their fans in the postseason. Now they have the perfect setting to turn this situation around at home and take the first step toward advancing to the next round.  

Though they aren't in the best run of form, winning just 4 of their last 10 games, the Cubs are a different team at home. We believe they will fully benefit from home-field advantage on this first night of Wild Card games. Furthermore, the Padres are under .500 on the road this season.

Our pick for the Wild Card matchup between the Cubs and the San Diego Padres is: Cubs ML.

Prediction:

 

Chicago Cubs wins the match

-116
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San Diego Padres vs Chicago Cubs Picks