Portland Trail Blazers vs San Antonio Spurs Prediction & Picks - NBA

USA - NBA

Portland Trail Blazers
4/24/26 22:30
San Antonio Spurs

Prediction:

 

The Spurs -2.5 points

-110
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 by Lou Aguila | in NBA Picks

Playing without Victor Wembanyama in Game 3, the San Antonio Spurs get an opportunity to showcase their depth and defense against the increasingly confident Portland Trail Blazers.

Momentum: The San Antonio Spurs and the Portland Trail Blazers split the first two games of the series, which further amplifies the importance of Friday night’s Game 3 at Moda Center.

The Spurs took Game 1 convincingly, 111-98, behind the all-around brilliance of MVP candidate Victor Wembanyama, who debuted in the playoffs with 35 points, 5 rebounds, and 2 blocks.

Unfortunately, disaster struck for San Antonio in Game 2 as Wembanyama exited early because of a concussion. Scott Henderson, the No.2 overall pick behind Wembanyama in the draft three years ago, owned the spotlight as he finished with 31 points on 11 for 17 shooting.

Hot on the Board: the Spurs are still the betting favorite at -140 despite not having a concussed Victor Wembanyama around for at least two more games and playing on the road. The spread is set at a razor-thin 2.5 points, which is a sign that bookmakers are beginning to respect the Blazers’ ability to produce an upset here now that San Antonio is playing without its MVP.

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Portland Trail Blazers vs San Antonio Spurs Form

Portland Trail Blazers and San Antonio Spurs Latest Matches

Portland Trail Blazers
Portland Trail Blazers Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2026 - NBA

San Antonio Spurs
103 :  106
Portland Trail Blazers

Apr 19, 2026 - NBA

San Antonio Spurs
111 :  98
Portland Trail Blazers

Apr 14, 2026 - NBA

Phoenix Suns
110 :  114
Portland Trail Blazers

Apr 12, 2026 - NBA

Portland Trail Blazers
122 :  110
Sacramento Kings

Apr 10, 2026 - NBA

Portland Trail Blazers
116 :  97
LA Clippers

Apr 8, 2026 - NBA

San Antonio Spurs
112 :  101
Portland Trail Blazers
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 12, 2026 - NBA

Portland Trail Blazers
122 :  110
Sacramento Kings

Apr 10, 2026 - NBA

Portland Trail Blazers
116 :  97
LA Clippers

Apr 2, 2026 - NBA

Portland Trail Blazers
118 :  106
New Orleans Pelicans

Mar 29, 2026 - NBA

Portland Trail Blazers
123 :  88
Washington Wizards

Mar 27, 2026 - NBA

Portland Trail Blazers
93 :  100
Dallas Mavericks

Mar 25, 2026 - NBA

Portland Trail Blazers
130 :  99
Milwaukee Bucks
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 21, 2026 - NBA

San Antonio Spurs
103 :  106
Portland Trail Blazers

Apr 19, 2026 - NBA

San Antonio Spurs
111 :  98
Portland Trail Blazers

Apr 14, 2026 - NBA

Phoenix Suns
110 :  114
Portland Trail Blazers

Apr 8, 2026 - NBA

San Antonio Spurs
112 :  101
Portland Trail Blazers

Apr 6, 2026 - NBA

Denver Nuggets
137 :  132
Portland Trail Blazers

Mar 31, 2026 - NBA

LA Clippers
104 :  114
Portland Trail Blazers
San Antonio Spurs
San Antonio Spurs Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2026 - NBA

San Antonio Spurs
103 :  106
Portland Trail Blazers

Apr 19, 2026 - NBA

San Antonio Spurs
111 :  98
Portland Trail Blazers

Apr 12, 2026 - NBA

San Antonio Spurs
118 :  128
Denver Nuggets

Apr 10, 2026 - NBA

San Antonio Spurs
139 :  120
Dallas Mavericks

Apr 8, 2026 - NBA

San Antonio Spurs
112 :  101
Portland Trail Blazers

Apr 6, 2026 - NBA

San Antonio Spurs
115 :  102
Philadelphia 76ers
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 21, 2026 - NBA

San Antonio Spurs
103 :  106
Portland Trail Blazers

Apr 19, 2026 - NBA

San Antonio Spurs
111 :  98
Portland Trail Blazers

Apr 12, 2026 - NBA

San Antonio Spurs
118 :  128
Denver Nuggets

Apr 10, 2026 - NBA

San Antonio Spurs
139 :  120
Dallas Mavericks

Apr 8, 2026 - NBA

San Antonio Spurs
112 :  101
Portland Trail Blazers

Apr 6, 2026 - NBA

San Antonio Spurs
115 :  102
Philadelphia 76ers
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 4, 2026 - NBA

Denver Nuggets
136 :  134
San Antonio Spurs

Apr 2, 2026 - NBA

LA Clippers
99 :  118
San Antonio Spurs

Apr 1, 2026 - NBA

Golden State Warriors
113 :  127
San Antonio Spurs

Mar 28, 2026 - NBA

Milwaukee Bucks
95 :  127
San Antonio Spurs

Mar 25, 2026 - NBA

Memphis Grizzlies
98 :  123
San Antonio Spurs

Mar 23, 2026 - NBA

Miami Heat
111 :  136
San Antonio Spurs

Portland Trail Blazers against San Antonio Spurs : Head to Head (H2H)

Portland Trail Blazers

50 %

San Antonio Spurs

50 %

Apr 21, 2026 - NBA

San Antonio Spurs
103 :  106
Portland Trail Blazers

Apr 19, 2026 - NBA

San Antonio Spurs
111 :  98
Portland Trail Blazers

Apr 8, 2026 - NBA

San Antonio Spurs
112 :  101
Portland Trail Blazers

Jan 3, 2026 - NBA

San Antonio Spurs
110 :  115
Portland Trail Blazers

Nov 26, 2025 - NBA

Portland Trail Blazers
102 :  115
San Antonio Spurs

Apr 6, 2025 - NBA

Portland Trail Blazers
120 :  109
San Antonio Spurs

Players list

Portland Trail Blazers
Portland Trail Blazers
D. Clingan

S. Henderson

J. Holiday

T. Camara

D. Avdija

San Antonio Spurs
San Antonio Spurs
D. Vassell L. Kornet

J. Champagnie

S. Castle

D. Fox

Substitutes

Portland Trail Blazers
Portland Trail Blazers
Y. Hansen M. Thybulle R. Williams III

B. Wesley

S. Cissoko

S. Sharpe

K. Murray

V. Krejci

J. Grant

San Antonio Spurs
San Antonio Spurs
K. Olynyk B. Biyombo M. Plumlee K. Johnson

D. Harper

L. Waters III

H. Barnes

C. Bryant

Portland Trail Blazers - San Antonio Spurs Key Points

  1. San Antonio is 7-3 SU in its last 10 games against Portland.
  2. San Antonio is 4-2 ATS in its last 6 games.
  3. Portland is 2-6 ATS in its last 8 games against an opponent in the Southwest Division
  4. Portland is 10-5 ATS in its last 15 games played in April.
Up to $250 to bet on Portland Trail Blazers - San Antonio Spurs! 

Limited Offer. Currently at Caesars Sportsbook

Our Portland Trail Blazers vs San Antonio Spurs Prediction

Fearless Forecast: The Spurs flex their depth to beat the Blazers 118-110

Without Victor Wembanyama, the San Antonio Spurs bank on their depth to grind out a tough win on the road in Game 3.

If you were keeping tabs with the Spurs throughout the season, you would know that they are more than just a Wembanyama one-man show. Even when Wemby was out for several weeks early this year, the team managed to compile a winning record and maintain its position in the brutal West Conference. As a matter of fact, the Spurs won 2 out of 3 regular-season meetings without the Blazers without Wembanyama.

De’Aaron Fox and Stephon Castle understand that they will now put up bigger numbers on offense to fill the void left by Wemby. The Spurs can also count on rookie Dylan Harper and the newly minted Sixth Man of the Year, Keldon Johnson, to contribute quality minutes off the bench.

I also expect the Spurs to employ a better game plan in slowing down Scott Henderson, who had a field day in Game 2. Luckily for the Spurs, they have a stash of athletic wingmen who can make Henderson work for his points, though Castle will likely get the assignment of guarding him for the majority of this game. Castle is a lockdown defender and someone I believe will be a perennial member of the All-Defensive teams in the coming days.

Our betting prediction for the San Antonio Spurs vs. the Portland Trail Blazers: The Spurs cover -2.5 points

Prediction:

 

The Spurs -2.5 points

-110
$250 offered for betting!

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Portland Trail Blazers vs San Antonio Spurs Picks