Michigan Wolverines vs Saint Louis Billikens Prediction & Picks - NCAA Basketball

USA - NCAA Basketball

Michigan Wolverines
3/21/26 12:10
Saint Louis Billikens

Prediction:

 

OVER 161.5

-110
$150 offered for betting!

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 by Travis Pulver | in NCAA Basketball Picks

The No. 9 seed Saint Louis Billikens will take on the No. 1-seed Michigan Wolverines in second-round action for the Midwest Region. Tip-off is scheduled for 12:10 p.m. EST on Saturday, March 21, at the KeyBank Center in Buffalo, NY. CBS is scheduled to broadcast the game.

Saint Louis is coming off an unexpectedly dominant performance in their Tournament opener vs. the Georgia Bulldogs. The Billikens shot an incredible 58% from the field to 35% for the Bulldogs, en route to a 1072-77 victory.  As for Michigan, it looked like they could be in danger of becoming the third No. 1 seed in Tournament history to lose in the first round. Howard stayed within striking distance in the first half and closed the gap to four points, 50-46, at the break. But then the Wolverines took over in the second half and won by a comfortable 21-point margin.

The Billikens hit nine of 28 3-pointers against the Bulldogs and dominated Georgia in the paint, 66-28. That will not be nearly as easy to accomplish against Michigan’s frontcourt. Saint Louis will need to take a page out of Howard’s playbook and create as many open looks from 3-point range as possible; Howard was 14-29 from 3-point range vs. the Wolverines.

Michigan Wolverines vs Saint Louis Billikens Form

Michigan Wolverines and Saint Louis Billikens Latest Matches

Michigan Wolverines
Michigan Wolverines Latest matches
W W W
Victories

3/3 (100%)

Defeats

0/3 (0%)

Mar 19, 2026 - NCAA Basketball

Michigan Wolverines
101 :  80
Howard Bison

Mar 22, 2025 - NCAA Basketball

Texas AM Aggies
79 :  91
Michigan Wolverines

Mar 20, 2025 - NCAA Basketball

Michigan Wolverines
68 :  65
UC San Diego Tritons
W W
Victories

2/2 (100%)

Defeats

0/2 (0%)

Mar 19, 2026 - NCAA Basketball

Michigan Wolverines
101 :  80
Howard Bison

Mar 20, 2025 - NCAA Basketball

Michigan Wolverines
68 :  65
UC San Diego Tritons
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Mar 22, 2025 - NCAA Basketball

Texas AM Aggies
79 :  91
Michigan Wolverines
Saint Louis Billikens
Saint Louis Billikens Latest matches
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Mar 19, 2026 - NCAA Basketball

Georgia Bulldogs
77 :  102
Saint Louis Billikens
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Mar 19, 2026 - NCAA Basketball

Georgia Bulldogs
77 :  102
Saint Louis Billikens
Michigan Wolverines vs Saint Louis Billikens Picks

Michigan Wolverines - Saint Louis Billikens Key Points

  1. Michigan is 15-20 ATS this season; Saint Louis is 18-12-3 ATS.
  2. Michigan was a 10.5-to-15.5-point favorite in eight games (three at 12.5 points) and failed to cover in all eight.
  3. The OVER is 14-21 for Michigan this season and 16-16-1 for Saint Louis.
  4. Betting Public: 57% of spread tickets and 70% of the handle are on Saint Louis.

Our Michigan Wolverines vs Saint Louis Billikens Prediction

Michigan strolled through the first round against Howard and still scored 100+ points and won by 21-points despite Howard hitting 14 of 29 3-pointers. Saint Louis was a 1.5-point underdog to Georgia, which would indicate a close game, but instead the underdog Billikens blew the Bulldogs out, 102-77. Both average around 87 points a game while allowing about 69. Michigan will dominate the paint; Saint Louis will dominate the 3-point line.

Who wins? That’s a good question. Michigan is a heavy favorite and could certainly use its size and athleticism to dominate this one. But if the Billikens get 12-15+ threes in this game (they average 11), this one could get interesting—and very high scoring.

Our Saint Louis vs. Michigan Pick: OVER 161.5

Prediction:

 

OVER 161.5

-110
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.