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by Lou Aguila in MLB Picks
San Diego Padres will go head-to-head with the Pittsburgh Pirates in Game 2 of their series at Petco Park.
The Padres are 4-1 in their last 5 games, averaging 5.7 runs per game but pitching a 4.21 ERA. They are two games behind the Los Angeles Dodgers (35-22) in the National League West standings. Gavin Sheet leads the team with 34 RBIs, while Manny Machado and Fernando Tatis pace the team in home runs (13) and batting average (.314).
The Pirates are 2-3 in their last 5 games to stay in the bottom of the NL Central standings with a 21-37 record. Pittsburgh has enjoyed success offensively, averaging 5.2 runs per game on a .262 batting average. Pittsburgh has also pitched a 3.98 ERA with Paul Skenes leading the team in ERA (2.15), Wins (4) and Strikeouts (77).
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Pittsburgh Pirates vs San Diego Padres Form
Table
Teams | % | P | W | L |
---|---|---|---|---|
7
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0.579 | 57 | 33 | 24 |
28
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0.367 | 60 | 22 | 38 |
Pittsburgh Pirates and San Diego Padres Latest Matches

3/6 (50%)
3/6 (50%)
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4/6 (67%)
2/6 (33%)
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2/6 (33%)
4/6 (67%)
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4/6 (67%)
2/6 (33%)
May 30, 2025 - MLB
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May 24, 2025 - MLB
3/6 (50%)
3/6 (50%)
May 30, 2025 - MLB
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May 18, 2025 - MLB
May 17, 2025 - MLB
2/6 (33%)
4/6 (67%)
May 25, 2025 - MLB
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Pittsburgh Pirates against San Diego Padres : Head to Head (H2H)
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Pittsburgh Pirates - San Diego Padres Key Points
- San Diego is 4-1 SU in its last 5 games.
- San Diego is 13-3 SU in its last 16 games against an opponent in the National League.
- Pittsburgh is 0-10 SU in its last 10 games against San Diego.
- Pittsburgh is 3-12 SU in its last 15 games on the road.
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Our Pittsburgh Pirates vs San Diego Padres Prediction
Why you should bet on the Padres to win: San Diego is 4-1 SU in its last five games and 10-0 in their previous 10 head-to-head meetings with the Pirates. They have also managed to cover the spread in these meetings six times. Dylan Cease has been on a slump as of late, but I expect him to bounce back against the Pirates, whom he has tormented in his last three appearances against the team. Cease sports a 1.30 ERA and 4.0 strikeouts per game in his last three starts vs. the Pirates. Pirates starter Bailey Falter has posted a 0.80 ERA over his last 5 starts, but lost his 2 games against the team.
Our betting prediction for the San Diego Padres vs. Pittsburgh Pirates: Padres -1.5 Runs.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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