Philadelphia Phillies vs Toronto Blue Jays Prediction & Picks - MLB

Prediction published on 6/3/25, 3:19 PM  by Carlos Zabala | Modified on 6/3/25 at 10:00 PM in MLB Picks

The Phillies' odds on a win over the Blue Jays for Tuesday's three-game interleague series were around -155, then jumped to -180, but by Monday's end, they were almost back to where they started. The Blue Jays are on a five-game winning streak after sweeping the Athletics in Sacramento, and their underdog odds of around +135 for Game 1 against the Phillies in Toronto look attractive.

However, the bookmakers are putting a lot of weight on the pitching matchup, which clearly favors the Phillies. Cristopher Sanchez, with a 4-1 record and averaging more than a strikeout per inning, will start for the Phillies on Tuesday. Meanwhile, the Jays' Bowden Francis is having a season to forget with a 5.04 ERA, but in his last outing he shed some light by pitching 5 scoreless innings against the Rangers, throwing 75 pitches and snapping his three-outing home run skid.

In the four games in Toronto, the Blue Jays' bats probably had the most hits in their 2025 season in a single series. They won 12-0 in Game 1, scored 11 the next day, and drove in eight runs in Games 3 and 4.