Penn State Nittany Lions vs Oregon Ducks Prediction & Picks - NCAA

Prediction published on 9/27/25, 4:10 PM  by Matt Lowrimore | Modified on 9/29/25 at 4:59 PM in NCAA Picks

Perhaps the best game on the Week 5 college football Saturday slate will see the 6th-ranked Oregon Ducks take on the 3rd-ranked Penn State Nittany Lions. Let’s take a look at the match statistics and predictions for this game between the Ducks and Nittany Lions.

Oregon enters this game with a record of 4-0 and 1-0 in the Big Ten. The Ducks most recently beat the Oregon State Beavers in Week 4 by a score of 41-7. Oregon’s offense had a total of 585 yards, while its defense allowed 147 yards. Quarterback Dante Moore threw for 305 yards and four touchdowns, while running back Jayden Limar led the team in rushing with 70 yards.

As for Penn State, they enter this game with a record of 3-0, and this will be their first Big Ten game of the season. The Nittany Lions most recently beat the Villanova Wildcats in week 3 by a score of 52-6. Penn State’s offense had a total of 465 yards, while its defense allowed 179 yards. Quarterback Drew Allar threw for 209 yards, one touchdown, and one interception, while running back Kaytron Allen led the team in rushing with 86 yards and one touchdown.