Ohio State Buckeyes vs Illinois Fighting Illini Prediction & Picks - NCAA

USA - NCAA

Ohio State Buckeyes
10/11/25 12:00
Illinois Fighting Illini

Prediction:

 

Illinois Fighting Illini +14.5

-115
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore in NCAA Picks

One of the most important games on Saturday’s Week 7 college football slate will feature a Big Ten matchup between the top-ranked Ohio State Buckeyes and the 17th-ranked Illinois Illini. Let’s take a look at the match statistics and predictions for this game between the Buckeyes and the Fighting Illini.

Ohio State enters this game with a record of 5-0 and 2-0 in the Big Ten. The Buckeyes most recently beat the Minnesota Golden Gophers in Week 6 by a score of 42-3. Ohio State’s offense had a total of 474 yards, while its defense allowed 162 yards. Quarterback Julian Sayin threw for 326 yards and three touchdowns, while running back Bo Jackson led the team in rushing with 63 yards and one touchdown.

As for Illinois, they enter this game with a record of 5-1 and 2-1 in the Big Ten. The Fighting Illini most recently beat the Purdue Boilermakers in Week 6 by a score of 43-27. The Fighting Illini offense had a total of 507 yards, while its defense allowed 453 yards. Quarterback Luke Altmyer threw for 390 yards and one touchdown, while running back Ca’Lil Valentine led the team in rushing with 95 yards and one touchdown.

Ohio State Buckeyes vs Illinois Fighting Illini Form

Table

Teams % P W D L
1
Ohio State Buckeyes
Ohio State Buckeyes
1 2 2 0 0
5
Illinois Fighting Illini
Illinois Fighting Illini
0.667 3 2 0 1

Ohio State Buckeyes and Illinois Fighting Illini Latest Matches

Ohio State Buckeyes
Ohio State Buckeyes Latest matches
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Oct 4, 2025 - NCAA

Minnesota Golden Gophers
3 :  42
Ohio State Buckeyes

Sep 27, 2025 - NCAA

Ohio State Buckeyes
24 :  6
Washington Huskies

Sep 13, 2025 - NCAA

Ohio Bobcats
9 :  37
Ohio State Buckeyes

Sep 6, 2025 - NCAA

Grambling State Tigers
0 :  70
Ohio State Buckeyes

Aug 30, 2025 - NCAA

Texas Longhorns
7 :  14
Ohio State Buckeyes

Jan 20, 2025 - NCAA

Ohio State Buckeyes
34 :  23
Notre Dame Fighting Irish
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Minnesota Golden Gophers
3 :  42
Ohio State Buckeyes

Sep 13, 2025 - NCAA

Ohio Bobcats
9 :  37
Ohio State Buckeyes

Sep 6, 2025 - NCAA

Grambling State Tigers
0 :  70
Ohio State Buckeyes

Aug 30, 2025 - NCAA

Texas Longhorns
7 :  14
Ohio State Buckeyes

Dec 21, 2024 - NCAA

Tennessee Volunteers
17 :  42
Ohio State Buckeyes

Nov 30, 2024 - NCAA

Michigan Wolverines
13 :  10
Ohio State Buckeyes
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Sep 27, 2025 - NCAA

Ohio State Buckeyes
24 :  6
Washington Huskies

Jan 20, 2025 - NCAA

Ohio State Buckeyes
34 :  23
Notre Dame Fighting Irish

Jan 10, 2025 - NCAA

Ohio State Buckeyes
28 :  14
Texas Longhorns

Jan 1, 2025 - NCAA

Ohio State Buckeyes
41 :  21
Oregon Ducks

Nov 16, 2024 - NCAA

Ohio State Buckeyes
31 :  7
Northwestern Wildcats

Nov 2, 2024 - NCAA

Ohio State Buckeyes
20 :  13
Penn State Nittany Lions
Illinois Fighting Illini
Illinois Fighting Illini Latest matches
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Illinois Fighting Illini
43 :  27
Purdue Boilermakers

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 13, 2025 - NCAA

Western Michigan Broncos
0 :  38
Illinois Fighting Illini

Sep 6, 2025 - NCAA

Illinois Fighting Illini
45 :  19
Duke Blue Devils

Aug 29, 2025 - NCAA

Western Illinois Leathernecks
3 :  52
Illinois Fighting Illini
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 13, 2025 - NCAA

Western Michigan Broncos
0 :  38
Illinois Fighting Illini

Aug 29, 2025 - NCAA

Western Illinois Leathernecks
3 :  52
Illinois Fighting Illini

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

South Carolina Gamecocks
17 :  21
Illinois Fighting Illini

Nov 16, 2024 - NCAA

Michigan State Spartans
16 :  38
Illinois Fighting Illini

Nov 2, 2024 - NCAA

Minnesota Golden Gophers
25 :  17
Illinois Fighting Illini
L W W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 4, 2025 - NCAA

Illinois Fighting Illini
43 :  27
Purdue Boilermakers

Sep 20, 2025 - NCAA

Illinois Fighting Illini
10 :  63
Indiana Hoosiers

Sep 6, 2025 - NCAA

Illinois Fighting Illini
45 :  19
Duke Blue Devils

Nov 30, 2024 - NCAA

Illinois Fighting Illini
38 :  28
Northwestern Wildcats

Nov 23, 2024 - NCAA

Illinois Fighting Illini
38 :  31
Rutgers Scarlet Knights

Oct 26, 2024 - NCAA

Illinois Fighting Illini
9 :  38
Oregon Ducks

Ohio State Buckeyes - Illinois Fighting Illini Key Points

  1. Illinois is 2-1 ATS vs the Big Ten this season
  2. Illinois is averaging 29.0 points per game vs the Big Ten
  3. Ohio State is 2-0 ATS vs the Big Ten
  4. Ohio State is averaging 33.0 points per game vs the Big Ten

Our Ohio State Buckeyes vs Illinois Fighting Illini Prediction

Ohio State is the clear favorite in this game, but could be tested against a solid Illinois team. The Fighting Illini have shaken off their embarrassing 63-10 loss to Indiana a few weeks ago and have since won two games in a row.

The biggest problem for Illinois will be the Ohio State defense, which has yet to allow more than nine points in a game this season. That being said, the Fighting Illini are averaging 37.0 points per game and have had a balanced mix of throwing and running the ball.

Add in the fact that Illinois will be playing at home, and our Ohio State Buckeyes vs Illinois Fighting Illini prediction is: Illinois Fighting Illini +14.5.

Prediction:

 

Illinois Fighting Illini +14.5

-115
$200 offered for betting!

Claim $200 for your Ohio State Buckeyes vs Illinois Fighting Illini wager!

DK Welcome Bonus

Would you like to bet on Ohio State Buckeyes vs Illinois Fighting Illini? For this NCAA match, DK treats you to an exclusive offer: a bonus of $200, no promo code needed! Take advantage while you still can!

Not registered yet? You can create your account now by filling in this form. A bonus of $200 awaits you on the Ohio State Buckeyes vs Illinois Fighting Illini match!

$200 available for Ohio State Buckeyes vs Illinois Fighting Illini

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Ohio State Buckeyes vs Illinois Fighting Illini Picks