Athletics vs Boston Red Sox Prediction & Picks - MLB

Prediction published on 9/17/25, 2:48 PM  by Erik Gibbs in MLB Picks

The Oakland Athletics and the Boston Red Sox square off this afternoon in the opener of a critical late-season series at Fenway Park. Oakland comes in at 70-80 on the year, fresh off a 7-4 road victory over the Cincinnati Reds that allowed them to secure some positive momentum. Although the A’s are technically still alive in the postseason hunt, they are on the verge of elimination and will need a near-perfect run to have any chance.

After this three-game set in Boston, Oakland will continue its road swing with a matchup against the Pittsburgh Pirates. The Athletics have quietly shown improvement in September, winning three straight before heading into this contest, and they will look to play spoiler against a playoff-hungry Red Sox team.

Boston, meanwhile, enters with an 82-68 record, sitting firmly in the American League Wild Card mix. They are coming off a 6-4 series-clinching win over the New York Yankees on Sunday. With one of the most balanced lineups in the majors, the Red Sox continue to find production up and down their batting order.

Trevor Story leads the way offensively with 24 home runs and 91 RBIs, ranking inside the top 50 across MLB in both categories. Alex Bregman has also heated up at the right time, carrying a six-game hitting streak into this series while adding 27 doubles, 17 homers, and 43 walks on the season. Following this series, Boston will head south for a road set against the Tampa Bay Rays, another crucial matchup that will help shape the playoff race.