Novak Djokovic vs Jan-Lennard Struff Prediction & Picks - ATP US Open

Prediction published on 8/31/25, 6:33 PM  by Lou Aguila | Modified on 9/1/25 at 1:13 AM in ATP US Open Picks

A clear-cut favorite at -650, Novak Djokovic braces for a tricky matchup with an upset-minded Jan-Lennard Struff of Germany in the fourth round of the 2025 US Open.

Current Form:

Djokovic will try to make it into the quarterfinals of every Grand Slam tournament this year, which would be an amazing feat for an elder statesman on the tour. The 38-year-old Djokovic continues to stamp his class against younger opposition. And although he wasn’t as sharp as he was during his heyday, the 24-time Grand Slam winner has been able to get things done with experience and a still formidable return game. Nole advanced to the third round by topping Learner Tien 6-1 7-6(3) 6-2, Zachary Svajda 6-7(5) 6-3 6-3 6-1, and Cameron Norrie 6-4 6-7(4) 6-2 6-3.

Struff bulldozed his way to the round of 16 of the 2025 US Open, racking up six consecutive wins – three from the qualifiers – to move one win away from securing his best finish in a Grand Slam event. Struff qualified for the main draw by taking down Arthur Casaux 7-6(4) 6-3 in the final qualifying match. Struff sustained his fine play in the main draw, eliminating Mackenzie McDonald 3-6 7-6(4) 6-3 6-3, stunning Holger Rune 7-6(5) 2-6 6-3 4-6 7-5 and blasting Frances Tiafoe in straight sets 6-4 6-3 7-6(7).