New York Mets vs San Diego Padres Prediction & Picks - MLB

USA - MLB

New York Mets
7/28/25 21:40
San Diego Padres

Prediction:

 

San Diego Padres win both halves

-124
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 by Erik Gibbs | in MLB Picks

The San Diego Padres host the New York Mets at Petco Park on July 28, 2025, opening a three-game series. San Diego enters with a 57–49 record (31–18 at home), sitting second in the NL West, while New York is 62–44 (25–28 on the road) and leads the NL East. The Mets are red-hot, riding a seven-game winning streak after sweeping the Giants in San Francisco.

In contrast, the Padres have won two straight games in St. Louis following a brief three-game skid. Manny Machado has helped spark San Diego’s recent uptick with a four-hit performance in a 9–2 win over the Cardinals, carrying momentum into this matchup.

San Diego’s offense is finding a rhythm, posting a .316 team on-base percentage and slugging six homers over their last 10 games. Machado is on a five-game hitting streak, batting .619 in that span with four doubles, a homer, and 6 RBIs. He leads the team in average (.300), home runs (19), and RBIs (66). Luis Arraez has also been productive, batting .390 during a 10-game hit streak.

The Mets, meanwhile, are scoring 4.2 runs per game over their last 10 and have belted nine home runs in that span. Brandon Nimmo is batting .282 with 7 RBIs over the last 10 games, and Brett Baty has added a .290 average with a couple of homers. Juan Soto leads the Mets with 25 home runs, and Pete Alonso has added 22 home runs and 81 RBIs. New York leads the NL with a 3.52 team ERA and has outscored opponents by nine runs over the last 10 games.

New York Mets vs San Diego Padres Form

Table

Teams % P W L
6
New York Mets
New York Mets
0.569 109 62 47
9
San Diego Padres
San Diego Padres
0.55 109 60 49

New York Mets and San Diego Padres Latest Matches

New York Mets
New York Mets Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Jul 27, 2025 - MLB

New York Mets
5 :  3
San Francisco Giants

Jul 26, 2025 - MLB

New York Mets
2 :  1
San Francisco Giants

Jul 25, 2025 - MLB

New York Mets
8 :  1
San Francisco Giants

Jul 23, 2025 - MLB

Los Angeles Angels
3 :  6
New York Mets

Jul 22, 2025 - MLB

Los Angeles Angels
2 :  3
New York Mets

Jul 21, 2025 - MLB

Los Angeles Angels
5 :  7
New York Mets
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 23, 2025 - MLB

Los Angeles Angels
3 :  6
New York Mets

Jul 22, 2025 - MLB

Los Angeles Angels
2 :  3
New York Mets

Jul 21, 2025 - MLB

Los Angeles Angels
5 :  7
New York Mets

Jul 20, 2025 - MLB

Cincinnati Reds
2 :  3
New York Mets

Jul 19, 2025 - MLB

Cincinnati Reds
5 :  2
New York Mets

Jul 18, 2025 - MLB

Cincinnati Reds
8 :  4
New York Mets
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jul 27, 2025 - MLB

New York Mets
5 :  3
San Francisco Giants

Jul 26, 2025 - MLB

New York Mets
2 :  1
San Francisco Giants

Jul 25, 2025 - MLB

New York Mets
8 :  1
San Francisco Giants

Jul 13, 2025 - MLB

New York Mets
2 :  3
Kansas City Royals

Jul 12, 2025 - MLB

New York Mets
3 :  1
Kansas City Royals

Jul 11, 2025 - MLB

New York Mets
8 :  3
Kansas City Royals
San Diego Padres
San Diego Padres Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 27, 2025 - MLB

San Diego Padres
9 :  2
St. Louis Cardinals

Jul 26, 2025 - MLB

San Diego Padres
3 :  1
St. Louis Cardinals

Jul 25, 2025 - MLB

San Diego Padres
0 :  3
St. Louis Cardinals

Jul 24, 2025 - MLB

San Diego Padres
7 :  9
St. Louis Cardinals

Jul 23, 2025 - MLB

San Diego Padres
2 :  3
Miami Marlins

Jul 22, 2025 - MLB

San Diego Padres
3 :  4
Miami Marlins
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 13, 2025 - MLB

Philadelphia Phillies
2 :  1
San Diego Padres

Jul 12, 2025 - MLB

Philadelphia Phillies
4 :  5
San Diego Padres

Jul 11, 2025 - MLB

Philadelphia Phillies
2 :  4
San Diego Padres

Jul 10, 2025 - MLB

Arizona Diamondbacks
3 :  4
San Diego Padres

Jul 9, 2025 - MLB

Arizona Diamondbacks
8 :  2
San Diego Padres

Jul 8, 2025 - MLB

Arizona Diamondbacks
0 :  1
San Diego Padres
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 27, 2025 - MLB

San Diego Padres
9 :  2
St. Louis Cardinals

Jul 26, 2025 - MLB

San Diego Padres
3 :  1
St. Louis Cardinals

Jul 25, 2025 - MLB

San Diego Padres
0 :  3
St. Louis Cardinals

Jul 24, 2025 - MLB

San Diego Padres
7 :  9
St. Louis Cardinals

Jul 23, 2025 - MLB

San Diego Padres
2 :  3
Miami Marlins

Jul 22, 2025 - MLB

San Diego Padres
3 :  4
Miami Marlins

New York Mets against San Diego Padres : Head to Head (H2H)

New York Mets

67 %

San Diego Padres

33 %

Aug 25, 2024 - MLB

New York Mets
2 :  3
San Diego Padres

Aug 24, 2024 - MLB

New York Mets
7 :  1
San Diego Padres

Aug 23, 2024 - MLB

New York Mets
0 :  7
San Diego Padres

Aug 22, 2024 - MLB

New York Mets
8 :  3
San Diego Padres

Jun 15, 2024 - MLB

San Diego Padres
1 :  5
New York Mets

Jun 14, 2024 - MLB

San Diego Padres
1 :  2
New York Mets

New York Mets - San Diego Padres Key Points

  1. The Padres are 13-3 in their last 16 home games vs. NL East teams
  2. The Mets are 1-4 in their last 5 games at Petco Park after a road win
  3. The Padres are 10-1 covering the run line in their last 11 home games vs. NL teams with a winning record
  4. The Mets are 4-15 covering the run line in their last 19 night games vs. the Padres after a win

Our New York Mets vs San Diego Padres Prediction

San Diego’s pitching staff has been without Joe Musgrove, Michael King, and Jhony Brito due to injuries, yet they’ve posted a 2.96 ERA over their last 10 games. The Mets have dealt with a rash of injuries, including Tylor Megill, Max Kranick, Griffin Canning, and Jesse Winker. Despite this, New York has maintained a 3.13 ERA over their last 10 games, with excellent bullpen support.

The Padres will send Dylan Cease to the mound, while the Mets counter with Frankie Montas. Cease enters his 22nd start with a 3–10 record and a 4.59 ERA. He has 144 strikeouts in 113 2/3 innings but has also allowed 16 home runs and walked 42. In his last outing, he gave up two earned runs over five innings. Montas is 3–1 with a 4.62 ERA in five starts, allowing 23 strikeouts in 25 1/3 innings. He threw 5 2/3 innings of two-run ball in his last start.

The Padres are slight home favorites. The game is expected to be tight, with a projected score around 5–4 in favor of San Diego. Machado’s hot streak and San Diego’s deep bullpen give them a slight edge. Our prediction for San Diego Padres vs. New York Mets: Padres to win.

Prediction:

 

San Diego Padres win both halves

-124
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New York Mets vs San Diego Padres Picks