New Orleans Saints vs New England Patriots Prediction & Picks - NFL

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New Orleans Saints
10/12/25 13:00
New England Patriots

Prediction:

 

Saints to win

+155
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 by Simon Day | in NFL Picks

The Saints and Patriots both enjoyed superb upset victories last weekend, so an exciting contest looks to be in store when the teams go head-to-head at the Superdome in Week 6 of the NFL season. 

New England completed a shock 23-20 road victory over the previously undefeated Buffalo Bills on Sunday night, thanks to a fantastic all-round performance, led by blossoming second-year QB Drake Maye. It's early days for new Pats HC Mike Vrabel, but the signs are extremely positive as he attempts to return the franchise to its past glories. 

The Saints' Week 5 victory was also down to an excellent all-round team effort that saw them overcome the Giants 26-14. After QB Spencer Rattler led the Saints to a narrow half time lead, the Saints' defence completely took over in the second half, shutting out the Giants and allowing Rattler to comfortably secure his first ever NFL victory. 

New Orleans Saints vs New England Patriots Form

Table

Teams Pts P W L
3 New England Patriots
0.824 17 14 3
25 New Orleans Saints
0.353 17 6 11

New Orleans Saints and New England Patriots Latest Matches

New Orleans Saints
New Orleans Saints Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Oct 5, 2025 - NFL

New Orleans Saints
26 :  14
New York Giants

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Jan 5, 2025 - NFL

Tampa Bay Buccaneers
27 :  19
New Orleans Saints
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 5, 2025 - NFL

New Orleans Saints
26 :  14
New York Giants

Sep 14, 2025 - NFL

New Orleans Saints
21 :  26
San Francisco 49ers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 29, 2024 - NFL

New Orleans Saints
10 :  25
Las Vegas Raiders

Dec 15, 2024 - NFL

New Orleans Saints
19 :  20
Washington Commanders

Nov 17, 2024 - NFL

New Orleans Saints
35 :  14
Cleveland Browns
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 21, 2025 - NFL

Seattle Seahawks
44 :  13
New Orleans Saints

Jan 5, 2025 - NFL

Tampa Bay Buccaneers
27 :  19
New Orleans Saints

Dec 23, 2024 - NFL

Green Bay Packers
34 :  0
New Orleans Saints

Dec 8, 2024 - NFL

New York Giants
11 :  14
New Orleans Saints

Nov 3, 2024 - NFL

Carolina Panthers
23 :  22
New Orleans Saints
New England Patriots
New England Patriots Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

New England Patriots
42 :  13
Carolina Panthers

Sep 21, 2025 - NFL

New England Patriots
14 :  21
Pittsburgh Steelers

Sep 14, 2025 - NFL

Miami Dolphins
27 :  33
New England Patriots

Sep 7, 2025 - NFL

New England Patriots
13 :  20
Las Vegas Raiders

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 28, 2025 - NFL

New England Patriots
42 :  13
Carolina Panthers

Sep 21, 2025 - NFL

New England Patriots
14 :  21
Pittsburgh Steelers

Sep 7, 2025 - NFL

New England Patriots
13 :  20
Las Vegas Raiders

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills

Dec 28, 2024 - NFL

New England Patriots
7 :  40
Los Angeles Chargers

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 14, 2025 - NFL

Miami Dolphins
27 :  33
New England Patriots

Dec 22, 2024 - NFL

Buffalo Bills
24 :  21
New England Patriots

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Nov 24, 2024 - NFL

Miami Dolphins
34 :  15
New England Patriots

Nov 10, 2024 - NFL

Chicago Bears
3 :  19
New England Patriots

New Orleans Saints against New England Patriots : Head to Head (H2H)

New Orleans Saints

100 %

New England Patriots

0 %

Oct 8, 2023 - NFL

New England Patriots
0 :  34
New Orleans Saints

New Orleans Saints - New England Patriots Key Points

  1. New England have the third worst red zone defence in the NFL this season
  2. The Saints have won their last 2 games against the Pats
  3. New Orleans have scored at least 20 points in each of their last 5 games against the Pats
  4. New England have not had a winning season since 2021

Our New Orleans Saints vs New England Patriots Prediction

The Patriots are clear favorites here, following their unexpectedly strong start to the season. However, we are backing the Saints to follow up their Week 5 victory with another home win. 

Spencer Rattler is quietly having a very efficient season behind center in New Orleans, and last weekend's victory will have given him a huge confidence boost.

The Pats are clearly the better overall side, but they are still struggling for consistency and are prone to having some seriously poor outings, such as the awful Week One defeat to the Raiders. 

Our prediction for New Orleans Saints vs New England Patriots is: Saints to win.

Prediction:

 

Saints to win

+155
$200 offered for betting!

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New Orleans Saints vs New England Patriots Picks