Naomi Osaka vs Amanda Anisimova Prediction & Picks - WTA US Open

Prediction published on 9/4/25, 4:12 PM  by Lou Aguila in Tennis Picks

Naomi Osaka will shoot for her fifth Grand Slam finals appearance on Thursday as she dukes it out with Amanda Anisimova of the United States in the women’s singles semifinals of the 2025 US Open.

Naomi Osaka, who would go on to win a title in the last four times she reached the semis of a Grand Slam event, is valued at -140 moneyline or a profit of $100 for a $140 bet if you picked her to win straight up on DraftKings.

Current Form:

Osaka will try to inch closer to a fifth Grand Slam title as she takes on Anisimova before a predominantly American crowd in Flushing Meadows, New York. Osaka, 21-6 on the hard court in 2025, has won 11 of her last 12 matches, including six terrific wins at the US Open. The 2025 Canadian Open runner-up defeated a lineup of quality opponents to reach this stage of the tournament. She swept Greetje Minnen in the first round 6-3 6-4, Hailey Baptist in the second 6-3 6-1, Coco Gauff in the round of 16 6-3 6-2 and Karolina Muchova in the quarterfinals 6-4 7-6(3). The only time Osaka dropped a set was against Daria Kasatkina, who took the second set to force a decider in the third round.

Anisimova reached her second consecutive Grand Slam semifinal after exacting revenge on her 2025 Wimbledon Open final tormentor, Iga Swiatek, 6-4 6-3, in Wednesday’s quarterfinals. Ranked No.9 in the world, the American had also taken down Kim Birrell 6-3 6-2, Maya Joint 7-6(2) 6-2, Jacqueline Cristian 6-4 4-6 6-2, and Beatriz Haddad Maia 6-0 6-3 before her straight-set masterpiece against the five-time Grand Slam winner. Anismova is enjoying her best year on the tour, having reached her first Grand Slam final at the Wimbledon Open and compiled an outstanding 38-15 record, including an 18-7 slate on the hard court.