Minnesota Twins vs Philadelphia Phillies Prediction & Picks - MLB

USA - MLB

Minnesota Twins
9/26/25 18:45
Philadelphia Phillies

Prediction:

 

The Twins will win

+134
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 by Lou Aguila in MLB Picks

The Philadelphia Phillies are set to kick off their final regular-season series against the Minnesota Twins on Friday at Citizens Bank Park.

The Phillies, the NL East champions, are -158 moneyline favorites ahead of the series-opener against the Twins, a team they have lost to 4 of their last five games.

Current Form:

The Phillies won the final two games of their series against the Miami Marlins, enhancing their regular-season record to 94-65. Over the last five games, Philadelphia has maintained a solid 3.20 ERA and averaged a modest 4.4 runs per game on a .256 batting average. Philadelphia has also posted more than two home runs per game (2.2 HR per game) over this five-game stretch.

The Twins are trying to close out their season on a high note, having won three of their last four games. After blanking the Texas Rangers 4-0 in Thursday’s series finale, Minnesota has lowered its ERA over the previous five games to 3.07 and WHIP to 0.97. Unfortunately, the Twins have still recorded mediocre offensive numbers in this stretch, averaging 3.3 runs per game on a .228 BA.

Minnesota Twins vs Philadelphia Phillies Form

Table

Teams % P W L
2
Philadelphia Phillies
Philadelphia Phillies
0.591 159 94 65
26
Minnesota Twins
Minnesota Twins
0.434 159 69 90

Minnesota Twins and Philadelphia Phillies Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 25, 2025 - MLB

Minnesota Twins
4 :  0
Texas Rangers

Sep 24, 2025 - MLB

Minnesota Twins
2 :  4
Texas Rangers

Sep 23, 2025 - MLB

Minnesota Twins
4 :  1
Texas Rangers

Sep 21, 2025 - MLB

Cleveland Guardians
2 :  6
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
8 :  0
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
6 :  0
Minnesota Twins
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - MLB

Cleveland Guardians
2 :  6
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
8 :  0
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
6 :  0
Minnesota Twins

Sep 19, 2025 - MLB

Cleveland Guardians
6 :  2
Minnesota Twins

Sep 17, 2025 - MLB

New York Yankees
10 :  5
Minnesota Twins

Sep 16, 2025 - MLB

New York Yankees
10 :  9
Minnesota Twins
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 25, 2025 - MLB

Minnesota Twins
4 :  0
Texas Rangers

Sep 24, 2025 - MLB

Minnesota Twins
2 :  4
Texas Rangers

Sep 23, 2025 - MLB

Minnesota Twins
4 :  1
Texas Rangers

Sep 10, 2025 - MLB

Minnesota Twins
3 :  4
Los Angeles Angels

Sep 9, 2025 - MLB

Minnesota Twins
2 :  12
Los Angeles Angels

Sep 8, 2025 - MLB

Minnesota Twins
12 :  3
Los Angeles Angels
Philadelphia Phillies
Philadelphia Phillies Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 25, 2025 - MLB

Miami Marlins
0 :  1
Philadelphia Phillies

Sep 24, 2025 - MLB

Miami Marlins
1 :  11
Philadelphia Phillies

Sep 23, 2025 - MLB

Miami Marlins
6 :  5
Philadelphia Phillies

Sep 21, 2025 - MLB

Philadelphia Phillies
2 :  9
Arizona Diamondbacks

Sep 20, 2025 - MLB

Philadelphia Phillies
3 :  4
Arizona Diamondbacks

Sep 19, 2025 - MLB

Philadelphia Phillies
8 :  2
Arizona Diamondbacks
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 25, 2025 - MLB

Miami Marlins
0 :  1
Philadelphia Phillies

Sep 24, 2025 - MLB

Miami Marlins
1 :  11
Philadelphia Phillies

Sep 23, 2025 - MLB

Miami Marlins
6 :  5
Philadelphia Phillies

Sep 14, 2025 - MLB

Kansas City Royals
10 :  3
Philadelphia Phillies

Sep 13, 2025 - MLB

Kansas City Royals
6 :  8
Philadelphia Phillies

Sep 12, 2025 - MLB

Kansas City Royals
2 :  8
Philadelphia Phillies
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 21, 2025 - MLB

Philadelphia Phillies
2 :  9
Arizona Diamondbacks

Sep 20, 2025 - MLB

Philadelphia Phillies
3 :  4
Arizona Diamondbacks

Sep 19, 2025 - MLB

Philadelphia Phillies
8 :  2
Arizona Diamondbacks

Sep 17, 2025 - MLB

Philadelphia Phillies
0 :  5
Los Angeles Dodgers

Sep 16, 2025 - MLB

Philadelphia Phillies
9 :  6
Los Angeles Dodgers

Sep 15, 2025 - MLB

Philadelphia Phillies
6 :  5
Los Angeles Dodgers

Minnesota Twins against Philadelphia Phillies : Head to Head (H2H)

Minnesota Twins

50 %

Philadelphia Phillies

50 %

Mar 21, 2025 - MLB Spring Training

Minnesota Twins
3 :  6
Philadelphia Phillies

Mar 10, 2025 - MLB Spring Training

Philadelphia Phillies
4 :  1
Minnesota Twins

Jul 24, 2024 - MLB

Philadelphia Phillies
4 :  5
Minnesota Twins

Jul 23, 2024 - MLB

Philadelphia Phillies
3 :  0
Minnesota Twins

Jul 22, 2024 - MLB

Philadelphia Phillies
2 :  7
Minnesota Twins

Feb 27, 2024 - MLB Spring Training

Philadelphia Phillies
3 :  3
Minnesota Twins

Minnesota Twins - Philadelphia Phillies Key Points

  1. Minnesota is 5-10 SU in its last 15 games.
  2. Minnesota is 4-1 SU in its last 5 games against Philadelphia.
  3. Philadelphia is 14-6 SU in its last 20 games.
  4. Philadelphia is 4-2 SU in its last 6 games against an opponent in the American League Central Division

Our Minnesota Twins vs Philadelphia Phillies Prediction

Expect the Phillies to shut down their big bats like Bryce Harper, Trea Turner, and Kyle Schwarber for this series with the NL East title already in the bag. This could only mean Minnesota’s pitching staff will face Philadelphia’s batting lineup without the main engines of their offense.

Minnesota, 4-1 in their last five meetings against the Phillies, will start Joe Ryan (6.65 ERA in his last 5 starts). Ryan has lost his previous three starts and four of his last five, but the Twins are optimistic he will deliver a better showing against the Phillies’ shorthanded offense. Minnesota could also take advantage of Aaron Nola’s recent shaky form. Nola (6.35 ERA in his last five starts) has surrendered 10 runs over his previous two starts.

Again, the Phillies can afford to lose all three games in this series against Minnesota and still end up with the No.2 seed in the NL East.

Fearless Forecast: Twins 5, Phillies 2

Our betting prediction for the Minnesota Twins vs. the Philadelphia Phillies: Twins will win

Prediction:

 

The Twins will win

+134
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Minnesota Twins vs Philadelphia Phillies Picks