Minnesota Twins vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Minnesota Twins
8/22/25 19:40
Chicago White Sox

Prediction:

 

The Twins will win

-139
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 by Lou Aguila | in MLB Picks

Booked as -139 favorites at DraftKings, the Minnesota Twins eye their 9th win in their last 11 meetings against the Chicago White Sox on Friday at Rate Field.

The Twins were on the receiving end of a three-game sweep against the Athletics this week. Only a miracle now can send Minnesota back to the postseason after compiling 58-69 in the season, fourth in the AL Central. Moreover, the Twins are missing the service of one of their most reliable hurlers, Simeon Woods-Richardson, who is still on the 15-day IL due to illness.

Similar to the Twins, the White Sox are now out of the postseason race after amassing only 45 wins this late in the season. Chicago is dead last in the AL Central record with a 45-82 record. The White Sox fall in the bottom percentile in both key offense and pitching categories. They rank 27th in total runs (490), 29th in batting average (.231), 19th in ERA (4.18), and 25th in WHIP (1.37).

Minnesota Twins vs Chicago White Sox Form

Table

Teams % P W L
27
Minnesota Twins
Minnesota Twins
0.432 162 70 92
29
Chicago White Sox
Chicago White Sox
0.37 162 60 102

Minnesota Twins and Chicago White Sox Latest Matches

Minnesota Twins
Minnesota Twins Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 21, 2025 - MLB

Athletics
8 :  3
Minnesota Twins

Aug 20, 2025 - MLB

Athletics
4 :  2
Minnesota Twins

Aug 19, 2025 - MLB

Athletics
6 :  3
Minnesota Twins

Aug 17, 2025 - MLB

Detroit Tigers
1 :  8
Minnesota Twins

Aug 16, 2025 - MLB

Detroit Tigers
8 :  5
Minnesota Twins

Aug 15, 2025 - MLB

Detroit Tigers
7 :  0
Minnesota Twins
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 21, 2025 - MLB

Athletics
8 :  3
Minnesota Twins

Aug 20, 2025 - MLB

Athletics
4 :  2
Minnesota Twins

Aug 19, 2025 - MLB

Athletics
6 :  3
Minnesota Twins

Aug 17, 2025 - MLB

Detroit Tigers
1 :  8
Minnesota Twins

Aug 16, 2025 - MLB

Detroit Tigers
8 :  5
Minnesota Twins

Aug 15, 2025 - MLB

Detroit Tigers
7 :  0
Minnesota Twins
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 13, 2025 - MLB

Minnesota Twins
4 :  1
New York Yankees

Aug 12, 2025 - MLB

Minnesota Twins
1 :  9
New York Yankees

Aug 11, 2025 - MLB

Minnesota Twins
2 :  6
New York Yankees

Aug 6, 2025 - MLB

Minnesota Twins
9 :  4
Detroit Tigers

Aug 5, 2025 - MLB

Minnesota Twins
6 :  3
Detroit Tigers

Aug 4, 2025 - MLB

Minnesota Twins
3 :  6
Detroit Tigers
Chicago White Sox
Chicago White Sox Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Chicago White Sox
0 :  1
Atlanta Braves

Aug 19, 2025 - MLB

Chicago White Sox
10 :  11
Atlanta Braves

Aug 18, 2025 - MLB

Chicago White Sox
13 :  9
Atlanta Braves

Aug 17, 2025 - MLB

Chicago White Sox
2 :  6
Kansas City Royals

Aug 16, 2025 - MLB

Chicago White Sox
2 :  6
Kansas City Royals

Aug 15, 2025 - MLB

Chicago White Sox
1 :  3
Kansas City Royals
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 13, 2025 - MLB

Detroit Tigers
1 :  0
Chicago White Sox

Aug 12, 2025 - MLB

Detroit Tigers
6 :  9
Chicago White Sox

Aug 11, 2025 - MLB

Detroit Tigers
2 :  1
Chicago White Sox

Aug 10, 2025 - MLB

Cleveland Guardians
4 :  6
Chicago White Sox

Aug 9, 2025 - MLB

Cleveland Guardians
3 :  1
Chicago White Sox

Aug 8, 2025 - MLB

Cleveland Guardians
9 :  5
Chicago White Sox
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Aug 20, 2025 - MLB

Chicago White Sox
0 :  1
Atlanta Braves

Aug 19, 2025 - MLB

Chicago White Sox
10 :  11
Atlanta Braves

Aug 18, 2025 - MLB

Chicago White Sox
13 :  9
Atlanta Braves

Aug 17, 2025 - MLB

Chicago White Sox
2 :  6
Kansas City Royals

Aug 16, 2025 - MLB

Chicago White Sox
2 :  6
Kansas City Royals

Aug 15, 2025 - MLB

Chicago White Sox
1 :  3
Kansas City Royals

Minnesota Twins against Chicago White Sox : Head to Head (H2H)

Minnesota Twins

67 %

Chicago White Sox

33 %

Apr 24, 2025 - MLB

Chicago White Sox
3 :  0
Minnesota Twins

Apr 23, 2025 - MLB

Chicago White Sox
3 :  6
Minnesota Twins

Apr 22, 2025 - MLB

Chicago White Sox
2 :  4
Minnesota Twins

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox

Apr 1, 2025 - MLB

Minnesota Twins
8 :  3
Chicago White Sox

Mar 31, 2025 - MLB

Minnesota Twins
0 :  9
Chicago White Sox

Minnesota Twins - Chicago White Sox Key Points

  1. Minnesota is 17-3 SU in its last 20 games against Chicago White Sox.
  2. Minnesota is 8-2 SU in its last 10 games when playing on the road against Chicago White Sox.
  3. Chicago White Sox is 1-6 SU in its last 7 games.
  4. Chicago White Sox is 2-4 SU in its last 6 games at home.

Our Minnesota Twins vs Chicago White Sox Prediction

Pick Minnesota to win.

The Twins are 17-3 SU in its last 20 games against Chicago White Sox. They are 8-2 SU in its last 10 games when playing on the road against the White Sox. I also think projected Twins starter Zeb Matthews will win his duel with White Sox starter Sean Burke, who is expected to make his first start since his triple-A stint. Matthews is not giving up too many runs recently, averaging 2.2 earned runs per game.

Moreover, the Twins could also take advantage of a horrendous White Sox bullpen that has given up a 12.46 ERA in their last five games. I could also pick the Twins -1.5 runs for more profits at +121, but I am hesitant to go all in because the White Sox have also been strong against the spread when playing teams from their division (12-8 ATS).

Our betting prediction for the Minnesota Twins vs. the Chicago White Sox: the Twins will win.

Prediction:

 

The Twins will win

-139
$300+ offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Minnesota Twins vs Chicago White Sox Picks