Milwaukee Brewers vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

Milwaukee Brewers
10/8/25 17:08
Chicago Cubs

Prediction:

 

Over 6.5

-116
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 by Erik Gibbs in MLB Picks

The Milwaukee Brewers hold a 2‑0 lead in their National League Division Series after dispatching the Chicago Cubs 7‑3 in Game 2. Milwaukee enjoyed a stellar 2025 regular season, compiling a 97‑65 record that topped the NL Central by five games. They forged that mark through balanced play: the Brewers ranked among league leaders in runs scored and team ERA, benefitting from strong defense and solid baserunning. Down the stretch they surged, winning nine of their last 12 games to secure home‑field advantage.

Chicago, meanwhile, finished the season 92‑70 and secured a wild‑card berth. The Cubs' regular season was defined by streaks of brilliance mixed with inconsistency; they posted a 50‑31 record at Wrigley Field but were only slightly above .500 on the road. In the postseason, the Cubs eked out a wild‑card series win but have struggled to match Milwaukee's scoring output in the NLDS.

The Brewers' offense has flexed its muscle, plating 14 runs across the first two games and capitalizing on two‑out opportunities. Chicago's pitching staff has been unable to escape jams, allowing timely hits that have turned close games into multi‑run deficits.

Milwaukee Brewers vs Chicago Cubs Form

Milwaukee Brewers and Chicago Cubs Latest Matches

Milwaukee Brewers
Milwaukee Brewers Latest matches
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 6, 2025 - MLB

Chicago Cubs
3 :  7
Milwaukee Brewers

Oct 4, 2025 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

Sep 28, 2025 - MLB

Cincinnati Reds
2 :  4
Milwaukee Brewers

Sep 27, 2025 - MLB

Cincinnati Reds
7 :  4
Milwaukee Brewers

Sep 26, 2025 - MLB

Cincinnati Reds
3 :  1
Milwaukee Brewers

Sep 24, 2025 - MLB

Milwaukee Brewers
3 :  1
San Diego Padres
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 6, 2025 - MLB

Chicago Cubs
3 :  7
Milwaukee Brewers

Oct 4, 2025 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

Sep 28, 2025 - MLB

Cincinnati Reds
2 :  4
Milwaukee Brewers

Sep 27, 2025 - MLB

Cincinnati Reds
7 :  4
Milwaukee Brewers

Sep 26, 2025 - MLB

Cincinnati Reds
3 :  1
Milwaukee Brewers

Sep 18, 2025 - MLB

Los Angeles Angels
2 :  5
Milwaukee Brewers
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 24, 2025 - MLB

Milwaukee Brewers
3 :  1
San Diego Padres

Sep 23, 2025 - MLB

Milwaukee Brewers
0 :  7
San Diego Padres

Sep 22, 2025 - MLB

Milwaukee Brewers
4 :  5
San Diego Padres

Sep 21, 2025 - MLB

Milwaukee Brewers
1 :  5
St. Louis Cardinals

Sep 20, 2025 - MLB

Milwaukee Brewers
3 :  2
St. Louis Cardinals

Sep 19, 2025 - MLB

Milwaukee Brewers
1 :  7
St. Louis Cardinals
Chicago Cubs
Chicago Cubs Latest matches
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 6, 2025 - MLB

Chicago Cubs
3 :  7
Milwaukee Brewers

Oct 4, 2025 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

Oct 2, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Oct 1, 2025 - MLB

San Diego Padres
3 :  0
Chicago Cubs

Sep 30, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Sep 28, 2025 - MLB

St. Louis Cardinals
0 :  2
Chicago Cubs
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 2, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Oct 1, 2025 - MLB

San Diego Padres
3 :  0
Chicago Cubs

Sep 30, 2025 - MLB

San Diego Padres
1 :  3
Chicago Cubs

Sep 28, 2025 - MLB

St. Louis Cardinals
0 :  2
Chicago Cubs

Sep 27, 2025 - MLB

St. Louis Cardinals
3 :  7
Chicago Cubs

Sep 26, 2025 - MLB

St. Louis Cardinals
1 :  12
Chicago Cubs
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Oct 6, 2025 - MLB

Chicago Cubs
3 :  7
Milwaukee Brewers

Oct 4, 2025 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

Sep 21, 2025 - MLB

Chicago Cubs
0 :  1
Cincinnati Reds

Sep 20, 2025 - MLB

Chicago Cubs
3 :  6
Cincinnati Reds

Sep 19, 2025 - MLB

Chicago Cubs
4 :  7
Cincinnati Reds

Sep 18, 2025 - MLB

Chicago Cubs
0 :  1
Cincinnati Reds

Milwaukee Brewers against Chicago Cubs : Head to Head (H2H)

Milwaukee Brewers

50 %

Chicago Cubs

50 %

Oct 6, 2025 - MLB

Chicago Cubs
3 :  7
Milwaukee Brewers

Oct 4, 2025 - MLB

Chicago Cubs
3 :  9
Milwaukee Brewers

Aug 21, 2025 - MLB

Milwaukee Brewers
4 :  1
Chicago Cubs

Aug 20, 2025 - MLB

Milwaukee Brewers
3 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
1 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
4 :  6
Chicago Cubs

Milwaukee Brewers - Chicago Cubs Key Points

  1. The Brewers are 3-2 ATS in their last 5 games
  2. The Cubs are 2-3 ATS in their last 5 games
  3. The Over is 3-2 in the Brewers' last 5 games
  4. The Over is 2-3 in the Cubs' last 5 games

Our Milwaukee Brewers vs Chicago Cubs Prediction

Milwaukee's lineup is fronted by former MVP Christian Yelich, whose return to All‑Star form included a .280 average and 25 homers. Catcher William Contreras emerged as one of the National League's best hitters at his position, batting over .300 with line‑drive power, while shortstop Willy Adames contributed 20‑plus home runs and slick fielding.

The starting rotation boasts co‑aces Corbin Burnes and Freddy Peralta; Burnes produced a sub‑3.00 ERA with elite strikeout‑to‑walk ratios, and Peralta fanned nine Cubs in Game 2, tying a franchise postseason record. Milwaukee's bullpen is strengthened by the ascension of prospect Jacob Misiorowski, a late‑season call‑up who has consistently hit triple digits on the radar gun and locked down multiple‑inning saves.

The Cubs counter with a core built around multi‑position slugger Christopher Morel, who topped 30 homers, and second baseman Nico Hoerner, whose high contact rate and speed set the table. Chicago's rotation features left‑hander Justin Steele, one of the league ERA leaders, and veteran Jameson Taillon; however, both have lacked run support in the series.

For the Cubs to extend the matchup, their offense must strike early and often against Milwaukee's starters, and the bullpen needs to stem the Brewers' late‑inning rallies. Milwaukee's combination of frontline pitching, timely hitting and a deep relief corps makes them the favorites to complete the sweep, though the Cubs have enough talent to force a return to Milwaukee if their bats awaken. Our prediction for Chicago Cubs vs. Milwaukee Brewers: Over 6.5 runs.

Prediction:

 

Over 6.5

-116
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Milwaukee Brewers vs Chicago Cubs Picks