USC Trojans vs Michigan Wolverines Prediction & Picks - NCAA

USA - NCAA

USC Trojans
10/11/25 19:30
Michigan Wolverines

Prediction:

 

Michigan Wolverines +3.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

Another one of the games on the Week 7 Saturday college football schedule will see the 15th-ranked Michigan Wolverines take on the USC Trojans in the Big Ten. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Wolverines.

Michigan enters this game with a record of 4-1 and 2-0 in the Big Ten. The Wolverines most recently beat the Wisconsin Badgers in Week 6 by a score of 24-10. Michigan’s offense had a total of 445 yards, while its defense allowed 252 yards. Quarterback Bryce Underwood threw for 270 yards and one touchdown, while running back Justice Haynes led the team in rushing with 117 yards and two touchdowns.

As for USC, they enter this game with a record of 4-1 and 2-1 in the Big Ten. The Trojans most recently lost to the Illinois Fighting Illini in Week 5 by a score of 34-32. USC’s offense had a total of 490 yards, while its defense allowed 502 yards. Quarterback Jayden Maiava threw for 364 yards, two touchdowns, and one interception, while running back Waymond Jordan led the team in rushing with 92 yards and two touchdowns.

USC Trojans vs Michigan Wolverines Form

Table

USC Trojans and Michigan Wolverines Latest Matches

USC Trojans
USC Trojans Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 27, 2025 - NCAA

Illinois Fighting Illini
34 :  32
USC Trojans

Sep 20, 2025 - NCAA

USC Trojans
45 :  31
Michigan State Spartans

Sep 13, 2025 - NCAA

Purdue Boilermakers
17 :  33
USC Trojans

Sep 6, 2025 - NCAA

USC Trojans
59 :  20
Georgia Southern Eagles

Aug 30, 2025 - NCAA

USC Trojans
73 :  13
Missouri State Bears

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans
W W W W W
Victories

5/5 (100%)

Defeats

0/5 (0%)

Sep 20, 2025 - NCAA

USC Trojans
45 :  31
Michigan State Spartans

Sep 6, 2025 - NCAA

USC Trojans
59 :  20
Georgia Southern Eagles

Aug 30, 2025 - NCAA

USC Trojans
73 :  13
Missouri State Bears

Sep 7, 2024 - NCAA

USC Trojans
48 :  0
Utah State Aggies

Sep 1, 2024 - NCAA

USC Trojans
27 :  20
LSU Tigers
L W L
Victories

1/3 (33%)

Defeats

2/3 (67%)

Sep 27, 2025 - NCAA

Illinois Fighting Illini
34 :  32
USC Trojans

Sep 13, 2025 - NCAA

Purdue Boilermakers
17 :  33
USC Trojans

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans
Michigan Wolverines
Michigan Wolverines Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Michigan Wolverines
24 :  10
Wisconsin Badgers

Sep 20, 2025 - NCAA

Nebraska Cornhuskers
27 :  30
Michigan Wolverines

Sep 13, 2025 - NCAA

Michigan Wolverines
63 :  3
Central Michigan Chippewas

Sep 6, 2025 - NCAA

Oklahoma Sooners
24 :  13
Michigan Wolverines

Aug 30, 2025 - NCAA

Michigan Wolverines
34 :  17
New Mexico Lobos

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Michigan Wolverines
24 :  10
Wisconsin Badgers

Sep 13, 2025 - NCAA

Michigan Wolverines
63 :  3
Central Michigan Chippewas

Aug 30, 2025 - NCAA

Michigan Wolverines
34 :  17
New Mexico Lobos

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans

Sep 14, 2024 - NCAA

Michigan Wolverines
28 :  18
Arkansas State Red Wolves

Sep 7, 2024 - NCAA

Michigan Wolverines
12 :  31
Texas Longhorns
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Sep 20, 2025 - NCAA

Nebraska Cornhuskers
27 :  30
Michigan Wolverines

Sep 6, 2025 - NCAA

Oklahoma Sooners
24 :  13
Michigan Wolverines

USC Trojans against Michigan Wolverines : Head to Head (H2H)

USC Trojans

0 %

Michigan Wolverines

100 %

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans

USC Trojans - Michigan Wolverines Key Points

  1. Michigan is 1-1 ATS vs the Big Ten
  2. Michigan is averaging 27.0 points per game vs the Big Ten
  3. USC is 0-3 ATS vs the Big Ten this season
  4. USC is averaging 36.7 points per game vs the Big Ten

Our USC Trojans vs Michigan Wolverines Prediction

USC is the small favorite in this matchup; however, they have not done well this season at putting teams away. In fact, the Trojans have yet to cover the spread in three games against the Big Ten. The most recent blunder for USC was an outright loss to Illinois, and even though they have had their bye week since, Michigan is not an opponent they can afford to slack off against.

The Wolverines have the better defense of these two teams by far, as they have not allowed more than 27 points in any game this season. Given this, our USC Trojans vs Michigan Wolverines prediction is: Michigan Wolverines +3.5 Alternate Spread.

Prediction:

 

Michigan Wolverines +3.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

USC Trojans vs Michigan Wolverines Picks