USC Trojans vs Michigan State Spartans Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
One of the crucial games on the Week 4 college football Saturday slate will be a Big Ten Conference game between the Michigan State Spartans and the 25th-ranked USC Trojans. Let’s take a look at the match statistics and predictions for this game between the Spartans and the Trojans.
Michigan State enters this game with a record of 3-0, and this will be their first Big Ten game of the season. The Spartans most recently beat the Youngstown State Penguins in Week 3 by a score of 41-24. Michigan State’s offense had a total of 444 yards, while its defense allowed 339 yards. Quarterback Aiden Chiles threw for 270 yards, one touchdown, and one interception, while also leading the team in rushing with 76 yards.
As for USC, they enter this game with a record of 3-0, and they are 1-0 in the Big Ten. The Trojans most recently beat the Purdue Boilermakers in Week 3 by a score of 33-17. USC’s offense had a total of 460 yards, while its defense allowed 357 yards. Quarterback Jayden Maiava threw for 282 yards, while running back Waymond Jordan led the team in rushing with 77 yards and one touchdown.
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USC Trojans vs Michigan State Spartans Form
Table
USC Trojans and Michigan State Spartans Latest Matches
5/6 (83%)
1/6 (17%)
Sep 13, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 30, 2025 - NCAA
Sep 21, 2024 - NCAA
Sep 7, 2024 - NCAA
Sep 1, 2024 - NCAA
4/4 (100%)
0/4 (0%)
Sep 6, 2025 - NCAA
Aug 30, 2025 - NCAA
Sep 7, 2024 - NCAA
Sep 1, 2024 - NCAA
1/2 (50%)
1/2 (50%)
Sep 13, 2025 - NCAA
Sep 21, 2024 - NCAA
3/5 (60%)
2/5 (40%)
Sep 13, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 29, 2025 - NCAA
Oct 4, 2024 - NCAA
Sep 28, 2024 - NCAA
3/4 (75%)
1/4 (25%)
Sep 13, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 29, 2025 - NCAA
Sep 28, 2024 - NCAA
0/1 (0%)
1/1 (100%)
Oct 4, 2024 - NCAA
USC Trojans - Michigan State Spartans Key Points
- USC is 0-1 ATS vs the Big Ten this season
- USC is averaging 55.0 points per game this season
- Michigan State is averaging 35.3 points per game this season
- This is Michigan State’s first Big Ten game of the season
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Our USC Trojans vs Michigan State Spartans Prediction
USC is the heavy favorite in this game, and while they have won their games by an average margin of 38.3 points per game this season, they may be worth fading in this matchup against Michigan State. The Trojans failed to cover the spread against Purdue in Week 3, and it is safe to say they are now facing a better team in Michigan State.
USC is at home in this matchup; however, the Spartans have been resilient so far this season. They have had success throwing and running the football; therefore, our Michigan State Spartans vs USC Trojans prediction is: Michigan State Spartans +17.5.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
