Indiana Hoosiers vs Michigan State Spartans Prediction & Picks - NCAA

USA - NCAA

Indiana Hoosiers
10/18/25 15:30
Michigan State Spartans

Prediction:

 

Indiana 27.5

-110
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 by Travis Pulver | in NCAA Picks

The No. 3 Indiana Hoosiers (6-0) will host the Michigan State Spartans (3-3) at Memorial Stadium in Bloomington, IN, at 3:30 p.m. EST Saturday. Fans can follow the action once the game gets underway via the Peacock app.

This could be a trap game if the Hoosiers are not careful. After taking down Oregon in Eugene last weekend, it would be natural for Indiana to feel like it can coast this week against a mediocre Spartans team. The Hoosier offense and defense rank inside the top ten in several statistical categories. Surely, they don’t need to bring their ‘A’ game to beat Michigan State, right? Then again, there isn’t much for the Spartans to hang their hats on. All three wins came during their soft non-conference schedule; they’ve lost by double digits in all three conference losses. Barring Indiana making a number of mistakes in this game, Michigan State’s best chance will be to develop a run game, control the clock, and keep Fernando Mendoza and the IU offense on the sideline.

But that will be easier said than done against an Indiana defense averaging 86 rushing yards per game allowed. It would also require the Spartans to play above and beyond how they’ve performed this season (131.2 rushing yards per game) against the toughest opponent they’ll face all season.

Indiana Hoosiers vs Michigan State Spartans Form

Table

Indiana Hoosiers and Michigan State Spartans Latest Matches

Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers

Sep 20, 2025 - NCAA

Indiana Hoosiers
63 :  10
Illinois Fighting Illini

Sep 12, 2025 - NCAA

Indiana Hoosiers
73 :  0
Indiana State Sycamores

Sep 6, 2025 - NCAA

Indiana Hoosiers
56 :  9
Kennesaw State Owls

Aug 30, 2025 - NCAA

Indiana Hoosiers
27 :  14
Old Dominion Monarchs
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Indiana Hoosiers
63 :  10
Illinois Fighting Illini

Sep 12, 2025 - NCAA

Indiana Hoosiers
73 :  0
Indiana State Sycamores

Sep 6, 2025 - NCAA

Indiana Hoosiers
56 :  9
Kennesaw State Owls

Aug 30, 2025 - NCAA

Indiana Hoosiers
27 :  14
Old Dominion Monarchs

Sep 28, 2024 - NCAA

Indiana Hoosiers
42 :  28
Maryland Terrapins

Sep 6, 2024 - NCAA

Indiana Hoosiers
77 :  3
Western Illinois Leathernecks
L W W
Victories

2/3 (67%)

Defeats

1/3 (33%)

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers

Dec 20, 2024 - NCAA

Notre Dame Fighting Irish
27 :  17
Indiana Hoosiers
Michigan State Spartans
Michigan State Spartans Latest matches
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 11, 2025 - NCAA

Michigan State Spartans
13 :  38
UCLA Bruins

Oct 4, 2025 - NCAA

Nebraska Cornhuskers
38 :  27
Michigan State Spartans

Sep 20, 2025 - NCAA

USC Trojans
45 :  31
Michigan State Spartans

Sep 13, 2025 - NCAA

Michigan State Spartans
41 :  24
Youngstown State Penguins

Sep 6, 2025 - NCAA

Michigan State Spartans
42 :  40
Boston College Eagles

Aug 29, 2025 - NCAA

Michigan State Spartans
23 :  6
Western Michigan Broncos
L W W W L
Victories

3/5 (60%)

Defeats

2/5 (40%)

Oct 11, 2025 - NCAA

Michigan State Spartans
13 :  38
UCLA Bruins

Sep 13, 2025 - NCAA

Michigan State Spartans
41 :  24
Youngstown State Penguins

Sep 6, 2025 - NCAA

Michigan State Spartans
42 :  40
Boston College Eagles

Aug 29, 2025 - NCAA

Michigan State Spartans
23 :  6
Western Michigan Broncos

Sep 28, 2024 - NCAA

Michigan State Spartans
7 :  38
Ohio State Buckeyes
L L L
Victories

0/3 (0%)

Defeats

3/3 (100%)

Oct 4, 2025 - NCAA

Nebraska Cornhuskers
38 :  27
Michigan State Spartans

Sep 20, 2025 - NCAA

USC Trojans
45 :  31
Michigan State Spartans

Oct 4, 2024 - NCAA

Oregon Ducks
31 :  10
Michigan State Spartans

Indiana Hoosiers - Michigan State Spartans Key Points

  1. Michigan State leads the all-time series vs. Indiana 50-19-2.
  2. Indiana blew out the Spartans in East Lansing last season, 47-10, but hasn't won back-to-back games vs. Michigan State since winning three in a row from 1967-69.
  3. Michigan State is 2-1 ATS in conference play; Indiana is 2-1 ATS in games where they were 20+-point favorites.
  4. Betting Public: 38% of spread tickets and 59% of the handle are on Michigan State.

Our Indiana Hoosiers vs Michigan State Spartans Prediction

As long as the Hoosiers don’t phone it in, Indiana will win this game (and there is no reason to believe that they will). So, the question is whether they can cover a 27.5-point spread. IU certainly has the firepower, whether they’re running the ball or via the pass game, to run up the score on the Spartans. Michigan State has talent, but not enough to slow the Hoosiers down. With how the Indiana defense has played, the Spartans may not get a first down until garbage time. It’s a giant spread,  but I think the Hoosiers will cover it against this Spartans team.

Our Michigan State vs. Indiana Pick: Indiana -27.5

Prediction:

 

Indiana 27.5

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Indiana Hoosiers vs Michigan State Spartans Picks