Indianapolis Colts vs Miami Dolphins Prediction & Picks - NFL

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Indianapolis Colts
9/7/25 13:00
Miami Dolphins

Prediction:

 

The Colts will win

-108
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 by Lou Aguila | in NFL Picks

The Indianapolis Colts will debut their new quarterback, Daniel Jones, in Sunday’s season opener against the visiting Miami Dolphins at Lucas Oil Stadium.

Bookmakers anticipate a close battle, with the Colts listed as slight favorites on the run line at -1.5 points (-102). It means the home team only needs to beat the Dolphins by at least two points to beat the spread.

Current Form:

After dropping their first two preseason games against the Baltimore Ravens (16-24) and the Golden Bay Packers (19-23), Indianapolis closed out its offseason buildup with a resounding 41-14 win over the Cincinnati Bengals. Backup quarterback Riley Leonard got a starting role in this game, covering 189 yards on 15 of 20 passing with one touchdown. Rookie running back Ulysses Bentley IV ran for 189 yards and scored one TD. Daniels Jones, who beat Anthony Richardson Sr. for the starting quarterback job, delivered solid numbers in the first two preseason games. Jones completed 10 of her 21 passes for 144 yards in a loss to the Ravens in Week 1 preseason and went 7-for-11 for 109 yards in another setback to the Packers.

The Dolphins wrapped up their three-game preseason schedule undefeated. Miami duked it out to a 24-24 tie with the Chicago Bears in Week 1 before outgunning the Detroit Lions 24-17 in Week 2. The Dolphins punctuated their offseason buildup with a 14-6 victory over the Jacksonville Jaguars in Week 3. Dolphins quarterback Tua Tagovailoa is set for his fifth consecutive season-opening start.

Indianapolis Colts vs Miami Dolphins Form

Table

Teams Pts P W L
20 Indianapolis Colts
0.471 17 8 9
22 Miami Dolphins
0.412 17 7 10

Indianapolis Colts and Miami Dolphins Latest Matches

Indianapolis Colts
Indianapolis Colts Latest matches
L W L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts

Nov 24, 2024 - NFL

Indianapolis Colts
6 :  24
Detroit Lions
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Nov 24, 2024 - NFL

Indianapolis Colts
6 :  24
Detroit Lions

Nov 10, 2024 - NFL

Indianapolis Colts
20 :  30
Buffalo Bills

Oct 20, 2024 - NFL

Indianapolis Colts
16 :  10
Miami Dolphins

Sep 29, 2024 - NFL

Indianapolis Colts
27 :  24
Pittsburgh Steelers
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts

Nov 17, 2024 - NFL

New York Jets
27 :  28
Indianapolis Colts

Nov 3, 2024 - NFL

Minnesota Vikings
21 :  13
Indianapolis Colts

Oct 27, 2024 - NFL

Houston Texans
23 :  20
Indianapolis Colts
Miami Dolphins
Miami Dolphins Latest matches
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jan 5, 2025 - NFL

New York Jets
32 :  20
Miami Dolphins

Dec 29, 2024 - NFL

Cleveland Browns
3 :  20
Miami Dolphins

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 15, 2024 - NFL

Houston Texans
20 :  12
Miami Dolphins

Dec 8, 2024 - NFL

Miami Dolphins
32 :  26
New York Jets

Nov 28, 2024 - NFL

Green Bay Packers
30 :  17
Miami Dolphins
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 22, 2024 - NFL

Miami Dolphins
29 :  17
San Francisco 49ers

Dec 8, 2024 - NFL

Miami Dolphins
32 :  26
New York Jets

Nov 24, 2024 - NFL

Miami Dolphins
34 :  15
New England Patriots

Nov 17, 2024 - NFL

Miami Dolphins
34 :  19
Las Vegas Raiders

Oct 27, 2024 - NFL

Miami Dolphins
27 :  28
Arizona Cardinals

Sep 30, 2024 - NFL

Miami Dolphins
12 :  31
Tennessee Titans
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jan 5, 2025 - NFL

New York Jets
32 :  20
Miami Dolphins

Dec 29, 2024 - NFL

Cleveland Browns
3 :  20
Miami Dolphins

Dec 15, 2024 - NFL

Houston Texans
20 :  12
Miami Dolphins

Nov 28, 2024 - NFL

Green Bay Packers
30 :  17
Miami Dolphins

Nov 11, 2024 - NFL

Los Angeles Rams
15 :  23
Miami Dolphins

Nov 3, 2024 - NFL

Buffalo Bills
30 :  27
Miami Dolphins

Indianapolis Colts against Miami Dolphins : Head to Head (H2H)

Indianapolis Colts

100 %

Miami Dolphins

0 %

Oct 20, 2024 - NFL

Indianapolis Colts
16 :  10
Miami Dolphins

Indianapolis Colts - Miami Dolphins Key Points

  1. Miami is 2-8 SU in its last 10 games against Indianapolis.
  2. Miami is 2-8 SU in its last 10 games against Indianapolis.
  3. Indianapolis is 8-2 SU in its last 10 games against an opponent in the American Football Conference East
  4. Indianapolis is 5-1 ATS in its last 6 games played in September.

Our Indianapolis Colts vs Miami Dolphins Prediction

Like most projections for this matchup, expect a back-and-forth battle between these two evenly-matched teams. The Colts are trying to win their first series-opening game for the first time in 12 years, and they are pinning their hopes on their newly acquired quarterback, Daniel Jones, to end the curse. Jones, who put up encouraging numbers in the preseason, will have dynamic wide receivers in Tyler Warren and Josh Downs, who can really deal heavy damage if they are utilized properly.

On the other hand, the Dolphins will try to squeeze out any good stuff left from veteran and former Pro Bowl wideout Tyreek Hill. The 31-year-old wideout looks to create more magic with Miami quarterback Tua Tagovailoa, who is trying to bounce back from a disappointing 2024 season campaign.

The Colts' defense is shaping up to be really good this year, or even better, depending on the performance of the personnel they added to soup up their secondary. Tagavailoa can still make the Dolphins a dangerous team if he finds his elite form back this season. However, I really believe that Daniel Jones will shine in Week 1, especially if he finds a way to find his weapons downfield.

Our betting prediction for the Indianapolis Colts vs. Miami Dolphins: the Colts will win.

Prediction:

 

The Colts will win

-108
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Indianapolis Colts vs Miami Dolphins Picks