Vanderbilt Commodores vs LSU Tigers Prediction & Picks - NCAA

USA - NCAA

Vanderbilt Commodores
10/18/25 12:00
LSU Tigers

Prediction:

 

LSU Tigers +3.5 Alternate Spread

-140
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 by Matt Lowrimore | in NCAA Picks

One of the many games on Saturday’s Week 8 college football slate will see the 10th-ranked LSU Tigers take on the 17th-ranked Vanderbilt Commodores in the SEC. Let’s take a look at the match statistics and predictions for this game between the Tigers and the Commodores.

LSU enters this game with a record of 5-1 and 2-1 in the SEC. The Tigers most recently beat the South Carolina Gamecocks in Week 7 by a score of 20-10. LSU’s offense had a total of 422 yards, while its defense allowed 317 yards. Quarterback Garrett Nussmeier threw for 254 yards, two touchdowns, and two interceptions, while running back Caden Durham led the team in rushing with 70 yards.

As for Vanderbilt, they enter this game with a record of 5-1 and 1-1 in the SEC. The Commodores most recently lost to the Alabama Crimson Tide in Week 6 by a score of 30-14. Vanderbilt’s offense had a total of 333 yards, while its defense allowed 486 yards. Quarterback Diego Pavia threw for 198 yards, one touchdown, and one interception, while running back Sedrick Alexander led the team in rushing with 76 yards and one touchdown.

Vanderbilt Commodores vs LSU Tigers Form

Table

Vanderbilt Commodores and LSU Tigers Latest Matches

Vanderbilt Commodores
Vanderbilt Commodores Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Alabama Crimson Tide
30 :  14
Vanderbilt Commodores

Sep 27, 2025 - NCAA

Vanderbilt Commodores
55 :  35
Utah State Aggies

Sep 20, 2025 - NCAA

Vanderbilt Commodores
70 :  21
Georgia State Panthers

Sep 13, 2025 - NCAA

South Carolina Gamecocks
7 :  31
Vanderbilt Commodores

Sep 6, 2025 - NCAA

Virginia Tech Hokies
20 :  44
Vanderbilt Commodores

Aug 30, 2025 - NCAA

Vanderbilt Commodores
45 :  3
Charleston Southern Buccaneers
W W W W
Victories

4/4 (100%)

Defeats

0/4 (0%)

Sep 27, 2025 - NCAA

Vanderbilt Commodores
55 :  35
Utah State Aggies

Sep 20, 2025 - NCAA

Vanderbilt Commodores
70 :  21
Georgia State Panthers

Aug 30, 2025 - NCAA

Vanderbilt Commodores
45 :  3
Charleston Southern Buccaneers

Oct 19, 2024 - NCAA

Vanderbilt Commodores
24 :  14
Ball State Cardinals
L W W L
Victories

2/4 (50%)

Defeats

2/4 (50%)

Oct 4, 2025 - NCAA

Alabama Crimson Tide
30 :  14
Vanderbilt Commodores

Sep 13, 2025 - NCAA

South Carolina Gamecocks
7 :  31
Vanderbilt Commodores

Sep 6, 2025 - NCAA

Virginia Tech Hokies
20 :  44
Vanderbilt Commodores

Sep 21, 2024 - NCAA

Missouri Tigers
30 :  27
Vanderbilt Commodores
LSU Tigers
LSU Tigers Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 11, 2025 - NCAA

LSU Tigers
20 :  10
South Carolina Gamecocks

Sep 27, 2025 - NCAA

Ole Miss Rebels
24 :  19
LSU Tigers

Sep 20, 2025 - NCAA

LSU Tigers
56 :  10
Southeastern Louisiana Lions

Sep 13, 2025 - NCAA

LSU Tigers
20 :  10
Florida Gators

Sep 6, 2025 - NCAA

LSU Tigers
23 :  7
Louisiana Tech Bulldogs

Aug 30, 2025 - NCAA

Clemson Tigers
10 :  17
LSU Tigers
W W W W W
Victories

5/5 (100%)

Defeats

0/5 (0%)

Oct 11, 2025 - NCAA

LSU Tigers
20 :  10
South Carolina Gamecocks

Sep 20, 2025 - NCAA

LSU Tigers
56 :  10
Southeastern Louisiana Lions

Sep 13, 2025 - NCAA

LSU Tigers
20 :  10
Florida Gators

Sep 6, 2025 - NCAA

LSU Tigers
23 :  7
Louisiana Tech Bulldogs

Sep 21, 2024 - NCAA

LSU Tigers
34 :  17
UCLA Bruins
L W W L
Victories

2/4 (50%)

Defeats

2/4 (50%)

Sep 27, 2025 - NCAA

Ole Miss Rebels
24 :  19
LSU Tigers

Aug 30, 2025 - NCAA

Clemson Tigers
10 :  17
LSU Tigers

Sep 14, 2024 - NCAA

South Carolina Gamecocks
33 :  36
LSU Tigers

Sep 1, 2024 - NCAA

USC Trojans
27 :  20
LSU Tigers

Vanderbilt Commodores - LSU Tigers Key Points

  1. Vanderbilt is 1-1 ATS vs the SEC
  2. Vanderbilt is averaging 22.5 points per game vs the SEC
  3. LSU is 2-1 ATS vs the SEC
  4. LSU is averaging 19.6 points per game vs the SEC

Our Vanderbilt Commodores vs LSU Tigers Prediction

As good as Vanderbilt has been this season, this will be another tough test. The good news is that the game will be played at Vanderbilt; however, there is still reason to believe that the Tigers will be able to walk out of Nashville with a win. 

LSU has not put a ton of points on the board in games against the SEC, but their defense has been more than up to the task, as they have allowed an average of 14.6 points per game in three SEC games. 

Vanderbilt quarterback, Diego Pavia, is likely going to be the X-factor in this matchup, but given how well LSU has been playing, our LSU Tigers vs Vanderbilt Commodores prediction is: LSU Tigers +3.5 Alternate Spread.

Prediction:

 

LSU Tigers +3.5 Alternate Spread

-140
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Vanderbilt Commodores vs LSU Tigers Picks