Ole Miss Rebels vs Louisville Cardinals Prediction & Picks - NCAA

Prediction published on 9/4/26, 7:30 PM  by Matt Lowrimore | Modified on 9/4/26 at 7:30 PM in NCAA Picks

The Week 1 College Football slate includes a handful of games on Sunday, one of which will feature a matchup between the Louisville Cardinals and the Ole Miss Rebels. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Rebels.

Ole Miss enters this game having finished the 2025-2026 season with a record of 13-2. The Rebels had an excellent season, despite losing Lane Kiffin as their head coach, advancing all the way to the College Football Playoff semifinals, before ultimately losing to the Miami Hurricanes. The expectations are just as high for the Rebels this season, who bring back a ton of talent and who look likely to begin this season with a win.

As for Louisville, they enter this game having finished the 2025-2026 season with a record of 9-4. The Cardinals were not a bad team last season, but were not consistent enough to be a real threat in the ACC. That said, Louisville consistently played solid defense last season, suggesting they will be able to limit what tends to be an explosive Ole Miss offense.