Michigan St. vs Louisville Cardinals Prediction & Picks - NCAA Basketball

USA - NCAA Basketball

Michigan St.
3/21/26 14:45
Louisville Cardinals

Prediction:

 

Michigan State Spartans ML

-192
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 by Matt Lowrimore | in NCAA Basketball Picks

The second round of the NCAA tournament kicks off all day Saturday, and one of the most exciting matchups will see the #6-seeded Louisville Cardinals take on the 3rd-seeded Michigan State Spartans. Let's take a look at the match statistics and predictions for this game between the Cardinals and the Spartans.

Michigan State came off a blowout win in the first round of the tournament, beating the North Dakota State Bison by a score of 92-67. This win pushes their overall record to 26-7, and they have now won three of their last five games. The Spartans put together a complete team effort, with four players scoring in double figures, led by Carson Cooper, who scored 20 points. On top of that, as a team, Michigan State had 26 assists, showing they can distribute the ball efficiently.

Louisville, on the other hand, outlasted South Florida in the first round, beating the Bulls by a score of 83-79. The win improves the Cardinals' record to 24-10 and is their fourth win in their last five games. Louisville had just three players score in double figures, including Ryan Conwell, who scored 18 points and Isaac McKeely, who scored 23 points.

Michigan St. vs Louisville Cardinals Form

Michigan St. and Louisville Cardinals Latest Matches

Michigan St.
Michigan St. Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Mar 19, 2026 - NCAA Basketball

Michigan St.
92 :  67
North Dakota State Bison

Mar 30, 2025 - NCAA Basketball

Auburn
70 :  64
Michigan St.

Mar 23, 2025 - NCAA Basketball

Michigan St.
71 :  63
New Mexico

Mar 21, 2025 - NCAA Basketball

Michigan St.
87 :  62
Bryant Bulldogs

Mar 23, 2024 - NCAA Basketball

North Carolina
85 :  69
Michigan St.

Mar 21, 2024 - NCAA Basketball

Mississippi State Bulldogs
51 :  69
Michigan St.
W W W
Victories

3/3 (100%)

Defeats

0/3 (0%)

Mar 19, 2026 - NCAA Basketball

Michigan St.
92 :  67
North Dakota State Bison

Mar 23, 2025 - NCAA Basketball

Michigan St.
71 :  63
New Mexico

Mar 21, 2025 - NCAA Basketball

Michigan St.
87 :  62
Bryant Bulldogs
W L L
Victories

1/3 (33%)

Defeats

2/3 (67%)

Mar 30, 2025 - NCAA Basketball

Auburn
70 :  64
Michigan St.

Mar 23, 2024 - NCAA Basketball

North Carolina
85 :  69
Michigan St.

Mar 21, 2024 - NCAA Basketball

Mississippi State Bulldogs
51 :  69
Michigan St.
Louisville Cardinals
Louisville Cardinals Latest matches
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Mar 19, 2026 - NCAA Basketball

Louisville Cardinals
83 :  79
South Florida Bulls

Mar 20, 2025 - NCAA Basketball

Louisville Cardinals
75 :  89
Creighton
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Mar 19, 2026 - NCAA Basketball

Louisville Cardinals
83 :  79
South Florida Bulls

Mar 20, 2025 - NCAA Basketball

Louisville Cardinals
75 :  89
Creighton
Michigan St. vs Louisville Cardinals Picks

Michigan St. - Louisville Cardinals Key Points

  1. Michigan State is 3-2 SU in March
  2. Michigan State is 3-2 ATS in March
  3. Louisville is 4-1 SU in March
  4. Louisville is 2-3 ATS in March

Our Michigan St. vs Louisville Cardinals Prediction

Michigan State is the moderate-sized favorite in this game; however, they still look to be the best betting option. Despite being in slightly worse form recently, the Spartans are a more balanced offense, and have four players averaging more than 11.0 points per game.

The main concern for Louisville is the absence of Mikel Brown Jr. The second leading scorer on the Cardinals missed the first round game and will also miss this game against the Spartans, as he is dealing with a back injury. 

Without him, Louisville survived in the first round, but facing stiffer competition in the second round could see an early exit for the Cardinals. 

With the injury to Brown Jr. and the fact that the Spartans have the better overall defense, our Louisville Cardinals vs Michigan State Spartans prediction is: Michigan State Spartans ML.

Prediction:

 

Michigan State Spartans ML

-192
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.