Louisville Cardinals vs Miami (FL) Hurricanes Prediction & Picks - NCAA

USA - NCAA

Louisville Cardinals
10/17/25 19:00
Miami (FL) Hurricanes

Prediction:

 

Louisville Cardinals +14.5 Alternate Spread

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 by Matt Lowrimore in NCAA Picks

Friday night will feature a handful of interesting games, including an ACC matchup between the 2nd-ranked Miami Hurricanes and the Louisville Cardinals. Let’s take a look at the match statistics and predictions for this game between the Hurricanes and the Cardinals.

Louisville enters this game with a record of 4-1 and 1-1 in the ACC. The Cardinals most recently lost to the Virginia Cavaliers by a score of 30-27 in Week 6. Louisville’s offense had a total of 383 yards, while its defense allowed 237 yards. Quarterback Miller Moss threw for 329 yards, two touchdowns, and one interception, while running back Isaac Brown led the team in rushing with 66 yards.

As for Miami, they enter this game with a record of 5-0 and 1-0 in the ACC. The Hurricanes most recently beat the Florida State Seminoles in Week 6 by a score of 28-22. Miami’s offense had a total of 338 yards, while its defense allowed 404 yards. Quarterback Carson Beck threw for 241 yards and four touchdowns, while running back Mark Fletcher Jr. led the team in rushing with 40 yards.

Louisville Cardinals vs Miami (FL) Hurricanes Form

Table

Teams % P W D L
8
Miami (FL) Hurricanes
Miami (FL) Hurricanes
1 1 1 0 0
10
Louisville Cardinals
Louisville Cardinals
0.5 2 1 0 1

Louisville Cardinals and Miami (FL) Hurricanes Latest Matches

Louisville Cardinals
Louisville Cardinals Latest matches
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Virginia Cavaliers
30 :  27
Louisville Cardinals

Sep 27, 2025 - NCAA

Louisville Cardinals
34 :  27
Pittsburgh Panthers

Sep 20, 2025 - NCAA

Bowling Green Falcons
17 :  40
Louisville Cardinals

Sep 5, 2025 - NCAA

James Madison Dukes
14 :  28
Louisville Cardinals

Aug 30, 2025 - NCAA

Eastern Kentucky Colonels
17 :  51
Louisville Cardinals

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Louisville Cardinals
35 :  34
Washington Huskies
L W W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 4, 2025 - NCAA

Virginia Cavaliers
30 :  27
Louisville Cardinals

Sep 20, 2025 - NCAA

Bowling Green Falcons
17 :  40
Louisville Cardinals

Sep 5, 2025 - NCAA

James Madison Dukes
14 :  28
Louisville Cardinals

Aug 30, 2025 - NCAA

Eastern Kentucky Colonels
17 :  51
Louisville Cardinals

Nov 23, 2024 - NCAA

Pittsburgh Panthers
9 :  37
Louisville Cardinals

Oct 19, 2024 - NCAA

Miami (FL) Hurricanes
52 :  45
Louisville Cardinals
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 27, 2025 - NCAA

Louisville Cardinals
34 :  27
Pittsburgh Panthers

Dec 31, 2024 - NCAA Division I, FBS, Playoffs

Louisville Cardinals
35 :  34
Washington Huskies

Nov 30, 2024 - NCAA

Louisville Cardinals
41 :  14
Kentucky Wildcats

Nov 16, 2024 - NCAA

Louisville Cardinals
35 :  38
Stanford Cardinal

Nov 2, 2024 - NCAA

Louisville Cardinals
33 :  21
Clemson Tigers

Oct 25, 2024 - NCAA

Louisville Cardinals
31 :  27
Boston College Eagles
Miami (FL) Hurricanes
Miami (FL) Hurricanes Latest matches
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 4, 2025 - NCAA

Miami (FL) Hurricanes
28 :  22
Florida State Seminoles

Sep 20, 2025 - NCAA

Florida Gators
7 :  26
Miami (FL) Hurricanes

Sep 13, 2025 - NCAA

South Florida Bulls
12 :  49
Miami (FL) Hurricanes

Sep 6, 2025 - NCAA

Bethune-Cookman Wildcats
3 :  45
Miami (FL) Hurricanes

Aug 31, 2025 - NCAA

Notre Dame Fighting Irish
24 :  27
Miami (FL) Hurricanes

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

Iowa State Cyclones
42 :  41
Miami (FL) Hurricanes
W L W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 20, 2025 - NCAA

Florida Gators
7 :  26
Miami (FL) Hurricanes

Sep 13, 2025 - NCAA

South Florida Bulls
12 :  49
Miami (FL) Hurricanes

Sep 6, 2025 - NCAA

Bethune-Cookman Wildcats
3 :  45
Miami (FL) Hurricanes

Aug 31, 2025 - NCAA

Notre Dame Fighting Irish
24 :  27
Miami (FL) Hurricanes

Dec 28, 2024 - NCAA Division I, FBS, Playoffs

Iowa State Cyclones
42 :  41
Miami (FL) Hurricanes

Nov 23, 2024 - NCAA

Wake Forest Demon Deacons
14 :  42
Miami (FL) Hurricanes
W W W L L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Oct 4, 2025 - NCAA

Miami (FL) Hurricanes
28 :  22
Florida State Seminoles

Nov 30, 2024 - NCAA

Miami (FL) Hurricanes
38 :  42
Syracuse Orange

Nov 9, 2024 - NCAA

Miami (FL) Hurricanes
23 :  28
Georgia Tech Yellow Jackets

Oct 19, 2024 - NCAA

Miami (FL) Hurricanes
52 :  45
Louisville Cardinals

Sep 21, 2024 - NCAA

Miami (FL) Hurricanes
50 :  15
South Florida Bulls

Aug 31, 2024 - NCAA

Miami (FL) Hurricanes
41 :  17
Florida Gators

Louisville Cardinals against Miami (FL) Hurricanes : Head to Head (H2H)

Oct 19, 2024 - NCAA

Miami (FL) Hurricanes
52 :  45
Louisville Cardinals

Louisville Cardinals - Miami (FL) Hurricanes Key Points

  1. Miami is 1-0 ATS vs the ACC
  2. Miami is averaging 28.0 points per game vs the ACC
  3. Louisville is 1-1 ATS vs the ACC
  4. Louisville is averaging 30.5 points per game vs the ACC

Our Louisville Cardinals vs Miami (FL) Hurricanes Prediction

Miami is the clear favorite, and even though they are playing at home, the spread in this game looks to be too steep. The Hurricanes have no doubt been one of the best teams in the country; however, they have not always dominated their opponents. In three games against a Power 5 opponent (Notre Dame, Florida, and Florida State), the Hurricanes have won by an average margin of 9.3 points per game.

Louisville, on the other hand, is coming off a tough upset loss at home against Virginia in overtime, but has otherwise been solid on both sides of the ball. Given that Miami has been vulnerable to slow starts or late comeback attempts, our Louisville Cardinals vs Miami Hurricanes prediction is: Louisville Cardinals +14.5 Alternate Spread.

Prediction:

 

Louisville Cardinals +14.5 Alternate Spread

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Louisville Cardinals vs Miami (FL) Hurricanes Picks