Philadelphia Eagles vs Los Angeles Rams Prediction & Picks - NFL

USA - NFL

Philadelphia Eagles
9/21/25 13:00
Los Angeles Rams

Prediction:

 

Over 45.5 points

-106
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 by Erik Gibbs | in NFL Picks

The Philadelphia Eagles vs. Los Angeles Rams clash represents one of the marquee NFC matchups of the early 2025 season. The Eagles, coming off back-to-back victories, will host the Rams, also unbeaten, in a game that carries not only pride but divisional and playoff implications.

With each team bringing contrasting styles—Philadelphia ground-oriented and methodical, Los Angeles high-flying through the air—the game promises strategic battles in both phases. The Eagles look to extend their dominance in recent head-to-head matchups, while the Rams aim to upset that trend on the road. The stage is set for a high-stakes, physical showdown under the lights at Lincoln Financial Field.

Philadelphia Eagles vs Los Angeles Rams Form

Table

Teams Pts P W L
5 Los Angeles Rams
0.706 17 12 5
10 Philadelphia Eagles
0.647 17 11 6

Philadelphia Eagles and Los Angeles Rams Latest Matches

Philadelphia Eagles
Philadelphia Eagles Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 14, 2025 - NFL

Kansas City Chiefs
17 :  20
Philadelphia Eagles

Sep 4, 2025 - NFL

Philadelphia Eagles
24 :  20
Dallas Cowboys

Feb 9, 2025 - NFL

Philadelphia Eagles
40 :  22
Kansas City Chiefs

Jan 26, 2025 - NFL

Philadelphia Eagles
55 :  23
Washington Commanders

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Jan 12, 2025 - NFL

Philadelphia Eagles
22 :  10
Green Bay Packers
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 4, 2025 - NFL

Philadelphia Eagles
24 :  20
Dallas Cowboys

Feb 9, 2025 - NFL

Philadelphia Eagles
40 :  22
Kansas City Chiefs

Jan 26, 2025 - NFL

Philadelphia Eagles
55 :  23
Washington Commanders

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Jan 12, 2025 - NFL

Philadelphia Eagles
22 :  10
Green Bay Packers

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 14, 2025 - NFL

Kansas City Chiefs
17 :  20
Philadelphia Eagles

Dec 22, 2024 - NFL

Washington Commanders
36 :  33
Philadelphia Eagles

Nov 24, 2024 - NFL

Los Angeles Rams
20 :  37
Philadelphia Eagles

Nov 10, 2024 - NFL

Dallas Cowboys
6 :  34
Philadelphia Eagles

Oct 27, 2024 - NFL

Cincinnati Bengals
17 :  37
Philadelphia Eagles

Oct 20, 2024 - NFL

New York Giants
3 :  28
Philadelphia Eagles
Los Angeles Rams
Los Angeles Rams Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 13, 2025 - NFL

Los Angeles Rams
27 :  9
Minnesota Vikings

Jan 5, 2025 - NFL

Los Angeles Rams
25 :  30
Seattle Seahawks

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 8, 2024 - NFL

Los Angeles Rams
44 :  42
Buffalo Bills

Nov 24, 2024 - NFL

Los Angeles Rams
20 :  37
Philadelphia Eagles
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Dec 22, 2024 - NFL

New York Jets
9 :  19
Los Angeles Rams

Dec 12, 2024 - NFL

San Francisco 49ers
6 :  12
Los Angeles Rams

Nov 17, 2024 - NFL

New England Patriots
22 :  28
Los Angeles Rams

Nov 3, 2024 - NFL

Seattle Seahawks
20 :  26
Los Angeles Rams

Philadelphia Eagles against Los Angeles Rams : Head to Head (H2H)

Philadelphia Eagles

100 %

Los Angeles Rams

0 %

Jan 19, 2025 - NFL

Philadelphia Eagles
28 :  22
Los Angeles Rams

Nov 24, 2024 - NFL

Los Angeles Rams
20 :  37
Philadelphia Eagles

Philadelphia Eagles - Los Angeles Rams: Form Analysis

Philadelphia has started the season impressively. In the first two games, their rushing attack has been among the NFL’s best, and they’ve played complementary defense that limits explosive plays. Their ball security has been excellent; few turnovers and disciplined execution in critical moments have been standout features.

Offensively, the Eagles have not leaned heavily on deep passing yet, but the offense is efficient between the 20s. Defensively, Philadelphia has shown strength against both the run and pass, particularly in fourth-down situations and red zone defense. They have also controlled the clock well and successfully benefited from turnovers.

On the Rams’ side, Los Angeles has also opened their campaign 2–0, showing that last season’s defensive identity is still central. Their pass rush has been disruptive and their secondary has forced incompletions and contested throws. Offensively, they have leaned more on aerial attack—Matthew Stafford has connected well with his top receivers and spreads the ball to multiple options.

While their running game has not been dominant, it has executed enough to keep defenses honest. Special teams have also contributed positive field position in both games. However, the Rams have had moments of vulnerability in defending power runs and short-yardage situations.

Philadelphia Eagles vs Los Angeles Rams Picks

Philadelphia Eagles & Los Angeles Rams Squad Analysis

For the Eagles, Jalen Hurts continues to play a dual-threat quarterback role. He has been careful with the ball, avoiding interceptions, while leaning on his legs in red zone situations. Saquon Barkley has been the fulcrum of the offense, producing consistent gains on the ground, breaking tackles, and finishing drives with touchdowns.

On defense, rookie and young players have been stepping up, making big plays at critical times—interceptions, key tackles for loss, and pressure packages have come through. The offensive line has also held up well, limiting negative plays and giving Hurts and Barkley room to operate.

For Los Angeles, Matthew Stafford has looked sharp and composed in the pocket, spreading the football effectively. Puka Nacua has made a strong early-season statement as a rookie receiver—despite not yet scoring, he's made huge yards after catch and has become a reliable option. Davante Adams has consistently drawn attention from defenses and made contested catches.

On the defensive side, Byron Young has been particularly disruptive at edge—he’s getting pressure and sacks. The secondary has also held tough in tight coverage, though they may be tested by big-play threats from Philadelphia. Special teams and rotational defensive linemen have provided value as well.

Philadelphia Eagles - Los Angeles Rams Key Points

  1. The Over is 5-1 in the Eagles’ last 6 games as favorites vs. the Rams
  2. The Over is 7-1 in the Rams’ last 8 Sunday games as underdogs
  3. The Eagles are 11-0 in their last 11 games at Lincoln Financial Field
  4. The Rams are 1-7 in their last 8 September road games vs. the NFC East teams

Our Philadelphia Eagles vs Los Angeles Rams Prediction

This game is likely to hinge on control— which team can assert its will at the line of scrimmage and manage the clock while limiting mistakes. Philadelphia’s ground game, led by Barkley and supported by a strong offensive line, may try to dominate early, chew up yardage, and keep the Rams’ offense off the field. Los Angeles will aim to make big plays in the passing game—Stafford targeting receivers like Nacua and Adams—while relying on their defense to force stops or turnovers.

If the Eagles can establish the run and control tempo, they’ll force Stafford into more pressured situations. Field position, special teams, and turnovers may decide tight moments. The Rams must find success on third downs and prevent Barkley from gashing them late when fatigue becomes a factor. Given the home-field edge, Philadelphia’s more balanced attack, and defensive stakes, I believe they'll edge this one in a close, physical battle. Our prediction for Philadelphia Eagles vs. Los Angeles Rams: Over 45.5 points.

Prediction:

 

Over 45.5 points

-106
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Philadelphia Eagles vs Los Angeles Rams - Other Interesting Picks

Saquon Barkley to score a TD

Odds -105
Given how he's already started the season, 2 TDs in 2 games, choosing Saquon Barkley to score in this game is an easy pick.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.