Los Angeles Rams vs Carolina Panthers Prediction & Picks - NFL
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by Erik Gibbs | in NFL Picks
The Carolina Panthers and Los Angeles Rams meet this Saturday in a Wild Card clash that features one of the most lopsided betting spreads in recent playoff history. Despite the Panthers entering as the NFC South champions with the home-field advantage at Bank of America Stadium, they finished the regular season with a sub-.500 record of 8-9 after dropping three of their final four contests.
Carolina’s recent form has been shaky, punctuated by a narrow 16-14 loss to Tampa Bay in the season finale, though they can take solace in the fact that they managed to upset these very Rams back in Week 13. On the other side of the ball, the Rams come into the postseason as one of the league's hottest but most volatile units, finishing 12-5 and securing the No. 5 seed.
While Los Angeles stumbled late in December with road losses to Seattle and Atlanta that cost them a higher seed, they bounced back in Week 18 with a dominant 37-20 win over Arizona to rediscover their offensive rhythm.
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Los Angeles Rams vs Carolina Panthers Form
Los Angeles Rams and Carolina Panthers Latest Matches
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Los Angeles Rams against Carolina Panthers : Head to Head (H2H)
Nov 30, 2025 - NFL
Los Angeles Rams - Carolina Panthers Key Points
- The Panthers are 5-0 in their last 5 games as home underdogs after a loss
- The Rams are 0-2 in their last 2 games as favorites vs. NFC South teams
- The Panthers are 13-0 ATS in their last 13 games as underdogs after a loss
- The Rams are 1-4 ATS in their last 5 road games without Kyren Williams
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Our Los Angeles Rams vs Carolina Panthers Prediction
Matthew Stafford and the Rams appear to have the upper hand offensively, as Stafford enters the playoffs coming off an MVP-caliber campaign where he led the league with 4,707 passing yards and 46 touchdowns. In his last outing just days ago, Stafford was clinical, tossing four touchdowns and showing zero signs of the back issues that bothered him earlier in the year. Puka Nacua and tight end Tyler Higbee have been his primary engines over the last two weeks, with Higbee notably returning from injury to rack up 91 yards and a score against the Cardinals.
However, the Rams are dealing with a significant blow to their front line, as right guard Kevin Dotson has been ruled out with an ankle injury, and tight end Terrance Ferguson remains questionable with a hamstring tweak.
For the Panthers, Bryce Young has shown flashes of brilliance in high-pressure moments, recently throwing two fourth-down touchdowns against the Bucs, but he will be without consistent protection if guards Robert Hunt and Chandler Zavala cannot shake their current questionable tags.
While the Panthers have the defensive grit to keep it close early—especially if the forecast of light rain slows down the track—the Rams' depth and Stafford’s elite form make them the clear pick to advance. Our prediction for Panthers vs. Rams: Under 44.5 points.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
