New York Giants vs Los Angeles Chargers Prediction & Picks - NFL

USA - NFL

New York Giants
9/28/25 13:00
Los Angeles Chargers

Prediction:

 

Chargers -6.5 points

-106
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 by Lou Aguila | in NFL Picks

The Los Angeles Chargers will take their immaculate 3-0 record into Sunday's week 4 clash with the New York Giants at MetLife Stadium.

The Chargers, 4-0 in their last four meetings with the Giants, are listed as -290 favorites and -106 on a -6.5-point handicap.

Current Form:

The Chargers roar into week 4 still undefeated after topping the Kansas City Chiefs 27-21, the Las Vegas Raiders 20-9, and the Denver Broncos 23-20. With quarterback Justin Herbert off to an explosive start, Los Angeles is averaging 270 passing yards per game (2nd in the NFL) and 23.3 points per game (14th). The Chargers’ defense is also elite, yielding an average of 16.7 points allowed per game (3rd in the NFL).

The Giants have gone 0-3 in their first three games this season. New York lost to the Washington Commanders 6-21 before absorbing a tough overtime loss to the Dallas Cowboys 37-40 in Week 2. In the third week, the Giants got manhandled by the Kansas City Chiefs 9-22 last week.

Quarterback Matchup:

Chargers quarterback Justin Herbert (860 yards with six TDs and one interception) vs. Giants quarterback Russell Wilson (778 yards with three TDs and three interceptions).

New York Giants vs Los Angeles Chargers Form

Table

Teams Pts P W L
9 Los Angeles Chargers
0.647 17 11 6
28 New York Giants
0.235 17 4 13

New York Giants and Los Angeles Chargers Latest Matches

New York Giants
New York Giants Latest matches
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs

Sep 14, 2025 - NFL

Dallas Cowboys
40 :  37
New York Giants

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 22, 2024 - NFL

Atlanta Falcons
34 :  7
New York Giants
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

New York Giants
9 :  22
Kansas City Chiefs

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

New York Giants
14 :  35
Baltimore Ravens

Dec 8, 2024 - NFL

New York Giants
11 :  14
New Orleans Saints

Nov 24, 2024 - NFL

New York Giants
7 :  30
Tampa Bay Buccaneers

Nov 3, 2024 - NFL

New York Giants
22 :  27
Washington Commanders
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

Dallas Cowboys
40 :  37
New York Giants

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants

Dec 22, 2024 - NFL

Atlanta Falcons
34 :  7
New York Giants

Nov 28, 2024 - NFL

Dallas Cowboys
27 :  20
New York Giants

Nov 10, 2024 - NFL

Carolina Panthers
20 :  17
New York Giants
Los Angeles Chargers
Los Angeles Chargers Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers

Dec 28, 2024 - NFL

New England Patriots
7 :  40
Los Angeles Chargers
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Dec 19, 2024 - NFL

Los Angeles Chargers
34 :  27
Denver Broncos

Dec 15, 2024 - NFL

Los Angeles Chargers
17 :  40
Tampa Bay Buccaneers

Nov 25, 2024 - NFL

Los Angeles Chargers
23 :  30
Baltimore Ravens

Nov 17, 2024 - NFL

Los Angeles Chargers
34 :  27
Cincinnati Bengals
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers

Dec 28, 2024 - NFL

New England Patriots
7 :  40
Los Angeles Chargers

Dec 8, 2024 - NFL

Kansas City Chiefs
19 :  17
Los Angeles Chargers

Dec 1, 2024 - NFL

Atlanta Falcons
13 :  17
Los Angeles Chargers

New York Giants - Los Angeles Chargers Key Points

  1. NY Giants is 1-9 SU in its last 10 games at home.
  2. NY Giants is 3-12 ATS in its last 15 games.
  3. LA Chargers is 6-1 ATS in its last 7 games.
  4. LA Chargers is 5-0 ATS in its last 5 games against NY Giants.

Our New York Giants vs Los Angeles Chargers Prediction

Chargers quarterback Justin Herbert (860 yards with six TDs and one interception) vs. Giants quarterback Russell Wilson (778 yards with three TDs and three interceptions).

The Chargers are in a position to make another statement win on the road against the Giants. In their last four inter-conference meetings, Los Angeles has gone 4-0 against New York. They are also 4-1 against the spread in their last five road games, proving that this team thrives even in a hostile environment.

If the Giants want to score an upset over the Chargers, they must first contain quarterback Justin Herbert, who has already amassed 860 passing yards with 6 TDs. Although he has already been sacked 10 times this season, Herbert has been tough as nails as he continues to torch opponents with his passing.

The Giants hope their quarterback, Russell Wilson, can turn back the hands of time and deliver a vintage performance on Sunday. However, Wilson and the offensive line will need to step up their game because they are facing a Chargers team that ranks 9th in the league against the pass (182.0 passing yards allowed per game).

Fearless Forecast: Charges 40, Giants 22

Our betting prediction for the Los Angeles Charges vs. the New York Giants: the Chargers -6.5 points

Prediction:

 

Chargers -6.5 points

-106
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

New York Giants vs Los Angeles Chargers Picks