Kansas City Chiefs vs Los Angeles Chargers Prediction & Picks - NFL

USA - NFL

Kansas City Chiefs
10/18/26 16:25
Los Angeles Chargers

Prediction:

 

Chiefs -7.5

−108
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Travis Pulver | in NFL Picks

The Kansas City Chiefs (4-0, 2-0 at Home) will look to keep the good times rolling as they return from their bye week to face the winless Los Angeles Chargers (0-5, 0-2 on the Road) at home. Fans can enjoy this AFC West matchup on CBS when the game begins at 4:25 p.m. EST.

Hopes were high for Kansas City coming into this season, with Patrick Mahomes returning after an injury last season. With a newfound running game with the acquisition of Kenneth Walker III, the offense has become dynamic once again. With a solid defense backing them up, the Chiefs are undefeated.

As for the Chargers, they’ve been the “good” team fans expected to break out any day now. But it looks like they are having the opposite kind of year this season. The offense has struggled to get on track (No. 30 in scoring, 16.8 points per game) while the defense has allowed 25.8 points per game (t-No. 22).

Kansas City leads the all-time series between these division rivals, 71-60-1. The Chargers won both games last season but had lost the previous seven matchups.

Kansas City Chiefs vs Los Angeles Chargers Form

Table

Teams Pts P W L
1 Kansas City Chiefs
1 4 4 0
30 Los Angeles Chargers
0 5 0 5

Kansas City Chiefs and Los Angeles Chargers Latest Matches

Kansas City Chiefs
Kansas City Chiefs Latest matches
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 4, 2026 - NFL

Las Vegas Raiders
27 :  30
Kansas City Chiefs

Sep 27, 2026 - NFL

Miami Dolphins
10 :  24
Kansas City Chiefs

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Sep 14, 2026 - NFL

Kansas City Chiefs
31 :  10
Denver Broncos

Jan 4, 2026 - NFL

Las Vegas Raiders
14 :  12
Kansas City Chiefs

Dec 25, 2025 - NFL

Kansas City Chiefs
13 :  20
Denver Broncos
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Sep 14, 2026 - NFL

Kansas City Chiefs
31 :  10
Denver Broncos

Dec 25, 2025 - NFL

Kansas City Chiefs
13 :  20
Denver Broncos

Dec 14, 2025 - NFL

Kansas City Chiefs
13 :  16
Los Angeles Chargers

Dec 7, 2025 - NFL

Kansas City Chiefs
10 :  20
Houston Texans

Nov 23, 2025 - NFL

Kansas City Chiefs
23 :  20
Indianapolis Colts
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 4, 2026 - NFL

Las Vegas Raiders
27 :  30
Kansas City Chiefs

Sep 27, 2026 - NFL

Miami Dolphins
10 :  24
Kansas City Chiefs

Jan 4, 2026 - NFL

Las Vegas Raiders
14 :  12
Kansas City Chiefs

Dec 21, 2025 - NFL

Tennessee Titans
26 :  9
Kansas City Chiefs

Nov 27, 2025 - NFL

Dallas Cowboys
31 :  28
Kansas City Chiefs

Nov 16, 2025 - NFL

Denver Broncos
22 :  19
Kansas City Chiefs
Los Angeles Chargers
Los Angeles Chargers Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Oct 11, 2026 - NFL

Los Angeles Chargers
17 :  23
Denver Broncos

Oct 4, 2026 - NFL

Seattle Seahawks
30 :  23
Los Angeles Chargers

Sep 27, 2026 - NFL

Buffalo Bills
24 :  16
Los Angeles Chargers

Sep 20, 2026 - NFL

Los Angeles Chargers
14 :  26
Las Vegas Raiders

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 11, 2026 - NFL

New England Patriots
16 :  3
Los Angeles Chargers
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 11, 2026 - NFL

Los Angeles Chargers
17 :  23
Denver Broncos

Sep 20, 2026 - NFL

Los Angeles Chargers
14 :  26
Las Vegas Raiders

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Dec 27, 2025 - NFL

Los Angeles Chargers
16 :  20
Houston Texans

Dec 8, 2025 - NFL

Los Angeles Chargers
22 :  19
Philadelphia Eagles

Nov 30, 2025 - NFL

Los Angeles Chargers
31 :  14
Las Vegas Raiders
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 4, 2026 - NFL

Seattle Seahawks
30 :  23
Los Angeles Chargers

Sep 27, 2026 - NFL

Buffalo Bills
24 :  16
Los Angeles Chargers

Jan 11, 2026 - NFL

New England Patriots
16 :  3
Los Angeles Chargers

Jan 4, 2026 - NFL

Denver Broncos
19 :  3
Los Angeles Chargers

Dec 21, 2025 - NFL

Dallas Cowboys
17 :  34
Los Angeles Chargers

Dec 14, 2025 - NFL

Kansas City Chiefs
13 :  16
Los Angeles Chargers

Kansas City Chiefs against Los Angeles Chargers : Head to Head (H2H)

Kansas City Chiefs

67 %

Los Angeles Chargers

33 %

Dec 14, 2025 - NFL

Kansas City Chiefs
13 :  16
Los Angeles Chargers

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Dec 8, 2024 - NFL

Kansas City Chiefs
19 :  17
Los Angeles Chargers

Sep 29, 2024 - NFL

Los Angeles Chargers
10 :  17
Kansas City Chiefs

Jan 7, 2024 - NFL

Los Angeles Chargers
12 :  13
Kansas City Chiefs

Oct 22, 2023 - NFL

Kansas City Chiefs
31 :  17
Los Angeles Chargers
Kansas City Chiefs vs Los Angeles Chargers Picks

Kansas City Chiefs - Los Angeles Chargers Key Points

  1. The Chargers defense has surrendered 118.8 yards per game on the ground; Kenneth Walker III is averaging just over 107 yards per game.
  2. Kansas City is averaging 29.5 points per game; the Chargers' defense has allowed 23-30 points per game.
  3. Betting Public: 62% of spread tickets and 55% of the handle are on the Rams.
  4. Betting Public: 60% of total tickets and 69% of the handle are on the OVER.

Our Kansas City Chiefs vs Los Angeles Chargers Prediction

Division rivalry games are typically competitive; the last five were decided by a touchdown or less. But there's little to hang your hat on with the Chargers' offense. Justin Herbert has completed just 59.4% of his passes and has a season high of just 226 yards with more interceptions (7) than touchdowns (5). LA’s defense may slow the Chiefs' offense in the first half, but they’ll be on the field too much to sustain any success. Kansas City will have a slight lead at the half, but Mahomes and the KC offense will come alive in the second half.

Our Chargers vs. Chiefs Pick: Kansas City -7.5

Prediction:

 

Chiefs -7.5

−108
$200 offered for betting!

A Welcome Bonus for Kansas City Chiefs vs Los Angeles Chargers!

DraftKings Welcome Bonus 200

Looking to place a bet on Kansas City Chiefs vs Los Angeles Chargers? For this NFL match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!

$200 in bonus bets for Kansas City Chiefs vs Los Angeles Chargers!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.