Liverpool vs Atletico Madrid Prediction & Picks - Champions League

Prediction published on 9/17/25, 11:23 AM  by Erik Gibbs in Champions League Picks

Atlético Madrid meet Liverpool in a Champions League big-hitter bout this Wednesday that has every chance of being a classic. The Reds go into this match in good nick, winning all of their opening league games with a blend of blistering attacking power and late-match fortitude. The fact that they grind out victories now has also become a signature, winning several games by final-minute winning goals. That speaks not only of strength in depth, but of what kind of group attitude has been forged by their gaffer.

Anfield has become a fortress again, and European evenings in this stadium too frequently have summoned up Liverpool's very best, which gives credence to what they're doing now. They feel confident, balanced, and equal to anything that's hurled at them.

Atlético Madrid, by contrast, started the season in less reassuring fashion. Initial La Liga slip-ups cost them points against opponents they would typically want to beat. They remain, by convention, one of Europe's hardest to break, pillars of defensive strength and determination. But moments of laxity have crept into their game, and cost them matches.

Despite this, Atlético remain a side that thrives in the spotlight. Champions League pedigree is unquestionable, and even in middle-of-the-road spells in La Liga, there is a tendency to rise to the occasion. Matches against clubs of this ilk of Liverpool are exactly the types in which defensive solidity and counterattack flair come to the fore, so dangerous foes are what they become in spite of a patchy opening.