Kansas City Royals vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 9/11/25, 4:04 PM  by Carlos Zabala | Modified on 9/11/25 at 9:50 PM in MLB Picks

Both the Royals and Guardians are currently out of the playoffs; Cleveland is three games away from the last Wild Card spot, and Kansas City is 3.5, so the Royals-Guardians series at Progressive Field is vital to both teams' hopes.

Game 1 of this four-game series was won by the Guards 10-2, with Cecconi no-hitting them into the eighth inning against the Royals. The Royals' offense continued to stall in Game 2, with Joey Cantillo shutting them out for eight innings. The Royals were then able to snap their three-game losing streak by winning the game 3-4-3, turning the score around with timely hits from Loftin and an RBI double from Maikel García.

Betting action for Game 4 has Cleveland as a -140 favorite at the bookmakers; This year they have been able to justify their home-field favoritism by playing at Progressive Field, as they have a 25-18 record in those games.