New York Giants vs Kansas City Chiefs Prediction & Picks - NFL

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New York Giants
9/21/25 20:20
Kansas City Chiefs

Prediction:

 

New York Giants +7.5 Alternate Spread

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 by Matt Lowrimore | in NFL Picks

The Week 3 Sunday night game is set to be an interesting one as the New York Giants will take on the Kansas City Chiefs. Let’s take a look at the match statistics and predictions for this game between the Giants and the Chiefs.

Kansas City enters this game with a record of 0-2, having most recently lost to the Philadelphia Eagles in Week 2 by a score of 20-17. The Chiefs’ offense had a total of 294 yards, while its defense allowed 216 yards. Quarterback Patrick Mahomes threw for 187 yards, one touchdown, and one interception, while also leading the team in rushing with 66 yards and one touchdown.

As for New York, they enter this game with a record of 0-2, having most recently lost to the Dallas Cowboys in Week 2 by a score of 40-37. The Giants’ offense had a total of 506 yards, while its defense allowed 478 yards. Quarterback Russell Wilson threw for 450 yards, three touchdowns, and one interception, while running back Cam Skattebo led the team in rushing with 45 yards and one touchdown.

New York Giants vs Kansas City Chiefs Form

Table

Teams Pts P W L
24 Kansas City Chiefs
0.353 17 6 11
28 New York Giants
0.235 17 4 13

New York Giants and Kansas City Chiefs Latest Matches

New York Giants
New York Giants Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 14, 2025 - NFL

Dallas Cowboys
40 :  37
New York Giants

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 22, 2024 - NFL

Atlanta Falcons
34 :  7
New York Giants

Dec 15, 2024 - NFL

New York Giants
14 :  35
Baltimore Ravens
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

New York Giants
14 :  35
Baltimore Ravens

Dec 8, 2024 - NFL

New York Giants
11 :  14
New Orleans Saints

Nov 24, 2024 - NFL

New York Giants
7 :  30
Tampa Bay Buccaneers

Nov 3, 2024 - NFL

New York Giants
22 :  27
Washington Commanders

Oct 20, 2024 - NFL

New York Giants
3 :  28
Philadelphia Eagles
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

Dallas Cowboys
40 :  37
New York Giants

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 5, 2025 - NFL

Philadelphia Eagles
20 :  13
New York Giants

Dec 22, 2024 - NFL

Atlanta Falcons
34 :  7
New York Giants

Nov 28, 2024 - NFL

Dallas Cowboys
27 :  20
New York Giants

Nov 10, 2024 - NFL

Carolina Panthers
20 :  17
New York Giants
Kansas City Chiefs
Kansas City Chiefs Latest matches
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

Kansas City Chiefs
17 :  20
Philadelphia Eagles

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Feb 9, 2025 - NFL

Philadelphia Eagles
40 :  22
Kansas City Chiefs

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 18, 2025 - NFL

Kansas City Chiefs
23 :  14
Houston Texans

Jan 5, 2025 - NFL

Denver Broncos
38 :  0
Kansas City Chiefs
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 14, 2025 - NFL

Kansas City Chiefs
17 :  20
Philadelphia Eagles

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 18, 2025 - NFL

Kansas City Chiefs
23 :  14
Houston Texans

Dec 21, 2024 - NFL

Kansas City Chiefs
27 :  19
Houston Texans

Dec 8, 2024 - NFL

Kansas City Chiefs
19 :  17
Los Angeles Chargers

Nov 29, 2024 - NFL

Kansas City Chiefs
19 :  17
Las Vegas Raiders
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Feb 9, 2025 - NFL

Philadelphia Eagles
40 :  22
Kansas City Chiefs

Jan 5, 2025 - NFL

Denver Broncos
38 :  0
Kansas City Chiefs

Dec 25, 2024 - NFL

Pittsburgh Steelers
10 :  29
Kansas City Chiefs

Dec 15, 2024 - NFL

Cleveland Browns
7 :  21
Kansas City Chiefs

Nov 24, 2024 - NFL

Carolina Panthers
27 :  30
Kansas City Chiefs
New York Giants vs Kansas City Chiefs Picks

New York Giants - Kansas City Chiefs Key Points

  1. Kansas City is 0-2 ATS this season
  2. New York is 1-1 ATS this season
  3. Kansas City is averaging 19.0 points per game this season
  4. New York is averaging 21.5 points per game this season

Our New York Giants vs Kansas City Chiefs Prediction

It is strange seeing the Chiefs struggle, but that is what we have seen this season as they have yet to win a game. However, Kansas City was competitive in both of their losses, having a chance to win in both games. 

As for New York, they have had two distinctly different games this season. In Week 1, they were dominated by Washington, while nearly beating Dallas in Week 2. How the Giants perform in this game is largely dependent on the play of Russell Wilson. He may not throw for 450 yards against the Chiefs, but we do think he will have another big game. For that reason, our New York Giants vs Kansas City Chiefs prediction is: New York Giants +7.5 Alternate Spread.

Prediction:

 

New York Giants +7.5 Alternate Spread

-157
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.