Kansas City Chiefs vs New York Giants Prediction & Picks - NFL

USA - NFL

Kansas City Chiefs
9/21/25 20:20
New York Giants

Prediction:

 

New York Giants +7.5 Alternate Spread

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 by Matt Lowrimore in NFL Picks

The Week 3 Sunday night game is set to be an interesting one as the New York Giants will take on the Kansas City Chiefs. Let’s take a look at the match statistics and predictions for this game between the Giants and the Chiefs.

Kansas City enters this game with a record of 0-2, having most recently lost to the Philadelphia Eagles in Week 2 by a score of 20-17. The Chiefs’ offense had a total of 294 yards, while its defense allowed 216 yards. Quarterback Patrick Mahomes threw for 187 yards, one touchdown, and one interception, while also leading the team in rushing with 66 yards and one touchdown.

As for New York, they enter this game with a record of 0-2, having most recently lost to the Dallas Cowboys in Week 2 by a score of 40-37. The Giants’ offense had a total of 506 yards, while its defense allowed 478 yards. Quarterback Russell Wilson threw for 450 yards, three touchdowns, and one interception, while running back Cam Skattebo led the team in rushing with 45 yards and one touchdown.

Kansas City Chiefs vs New York Giants Form

Table

Teams % P W D L
24
New York Giants
New York Giants
0 2 0 0 2
26
Kansas City Chiefs
Kansas City Chiefs
0 2 0 0 2

Kansas City Chiefs and New York Giants Latest Matches

Kansas City Chiefs
Kansas City Chiefs Latest matches
L W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Sep 14, 2025 - NFL

Philadelphia Eagles
20 :  17
Kansas City Chiefs

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Feb 9, 2025 - NFL

Kansas City Chiefs
22 :  40
Philadelphia Eagles

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 18, 2025 - NFL

Houston Texans
14 :  23
Kansas City Chiefs

Jan 5, 2025 - NFL

Kansas City Chiefs
0 :  38
Denver Broncos
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 14, 2025 - NFL

Philadelphia Eagles
20 :  17
Kansas City Chiefs

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs

Jan 18, 2025 - NFL

Houston Texans
14 :  23
Kansas City Chiefs

Dec 21, 2024 - NFL

Houston Texans
19 :  27
Kansas City Chiefs

Dec 8, 2024 - NFL

Los Angeles Chargers
17 :  19
Kansas City Chiefs

Nov 29, 2024 - NFL

Las Vegas Raiders
17 :  19
Kansas City Chiefs
W W W L L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Feb 9, 2025 - NFL

Kansas City Chiefs
22 :  40
Philadelphia Eagles

Jan 5, 2025 - NFL

Kansas City Chiefs
0 :  38
Denver Broncos

Dec 25, 2024 - NFL

Kansas City Chiefs
29 :  10
Pittsburgh Steelers

Dec 15, 2024 - NFL

Kansas City Chiefs
21 :  7
Cleveland Browns

Nov 24, 2024 - NFL

Kansas City Chiefs
30 :  27
Carolina Panthers
New York Giants
New York Giants Latest matches
L L W L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Sep 14, 2025 - NFL

New York Giants
37 :  40
Dallas Cowboys

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 5, 2025 - NFL

New York Giants
13 :  20
Philadelphia Eagles

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 22, 2024 - NFL

New York Giants
7 :  34
Atlanta Falcons

Dec 15, 2024 - NFL

Baltimore Ravens
35 :  14
New York Giants
L L L L L W
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Baltimore Ravens
35 :  14
New York Giants

Dec 8, 2024 - NFL

New Orleans Saints
14 :  11
New York Giants

Nov 24, 2024 - NFL

Tampa Bay Buccaneers
30 :  7
New York Giants

Nov 3, 2024 - NFL

Washington Commanders
27 :  22
New York Giants

Oct 20, 2024 - NFL

Philadelphia Eagles
28 :  3
New York Giants
L L L L L L
Victories

0/6 (0%)

Draw

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

New York Giants
37 :  40
Dallas Cowboys

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 5, 2025 - NFL

New York Giants
13 :  20
Philadelphia Eagles

Dec 22, 2024 - NFL

New York Giants
7 :  34
Atlanta Falcons

Nov 28, 2024 - NFL

New York Giants
20 :  27
Dallas Cowboys

Nov 10, 2024 - NFL

New York Giants
17 :  20
Carolina Panthers

Kansas City Chiefs - New York Giants Key Points

  1. Kansas City is 0-2 ATS this season
  2. New York is 1-1 ATS this season
  3. Kansas City is averaging 19.0 points per game this season
  4. New York is averaging 21.5 points per game this season

Our Kansas City Chiefs vs New York Giants Prediction

It is strange seeing the Chiefs struggle, but that is what we have seen this season as they have yet to win a game. However, Kansas City was competitive in both of their losses, having a chance to win in both games. 

As for New York, they have had two distinctly different games this season. In Week 1, they were dominated by Washington, while nearly beating Dallas in Week 2. How the Giants perform in this game is largely dependent on the play of Russell Wilson. He may not throw for 450 yards against the Chiefs, but we do think he will have another big game. For that reason, our New York Giants vs Kansas City Chiefs prediction is: New York Giants +7.5 Alternate Spread.

Prediction:

 

New York Giants +7.5 Alternate Spread

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Kansas City Chiefs vs New York Giants Picks