USC Trojans vs Iowa Hawkeyes Prediction & Picks - NCAA

Prediction published on 11/15/25, 12:29 PM  by Travis Pulver | Modified on 1/13/26 at 9:12 AM in NCAA Picks

The No. 17 USC Trojans will try to remain undefeated at home this weekend when they host the No. 21 Iowa Hawkeyes at the Los Angeles Memorial Coliseum in LA, CA. Kickoff for this Big Ten battle is scheduled for 3:30 p.m. EST. Fans can catch the action once the game gets underway on the Big Ten Network.

Iowa will come into the game fresh off its second Big Ten loss after losing a close one to Oregon at home, 18-16. They managed to hold the Ducks' offense to a single touchdown early on and even took a 16-15 lead late in the game after quarterback Mark Gronowski ran one in from three yards out. But the defense couldn’t hold the Ducks' offense back as Oregon moved into place to kick the game-winning field goal with three seconds left. As for the Trojans, USC won its second in a row after taking a loss against Notre Dame with a 38-17 win over Northwestern. Jayden Maiava had a good day,  going 24-33 for 299 yards, two touchdowns, and an interception. King Miller led a rushing attack that gained 173 yards and scored three times, with 127 yards and a touchdown on 15 carries.