Tennessee Titans vs Indianapolis Colts Prediction & Picks - NFL

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Tennessee Titans
9/21/25 13:00
Indianapolis Colts

Prediction:

 

Indianapolis Colts ML

-198
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 by Matt Lowrimore | in NFL Picks

One of the many games on the week 2 NFL slate will see the Indianapolis Colts take on the Tennessee Titans. Let’s take a look at the match statistics and predictions for this game between the Titans and the Colts.

Indianapolis enters this game with a record of 2-0, having most recently beaten the Denver Broncos in Week 2 by a score of 29-28. The Colts’ offense had a total of 473 yards, while its defense allowed 324 yards. Quarterback Daniel Jones threw for 316 yards and one touchdown, while running back Jonathan Taylor led the team in rushing with 165 yards.

As for Tennessee, they enter this game with a record of 0-2, having most recently lost to the Los Angeles Rams in Week 2 by a score of 33-19. The Titans’ offense had a total of 252 yards, while its defense allowed 439 yards. Quarterback Cam Ward threw for 175 yards and one touchdown, while running back Tony Pollard led the team in rushing with 92 yards.

Tennessee Titans vs Indianapolis Colts Form

Table

Teams Pts P W L
20 Indianapolis Colts
0.471 17 8 9
32 Tennessee Titans
0.176 17 3 14

Tennessee Titans and Indianapolis Colts Latest Matches

Tennessee Titans
Tennessee Titans Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Sep 7, 2025 - NFL

Denver Broncos
20 :  12
Tennessee Titans

Jan 5, 2025 - NFL

Tennessee Titans
14 :  23
Houston Texans

Dec 29, 2024 - NFL

Jacksonville Jaguars
20 :  13
Tennessee Titans

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Dec 15, 2024 - NFL

Tennessee Titans
27 :  37
Cincinnati Bengals
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Jan 5, 2025 - NFL

Tennessee Titans
14 :  23
Houston Texans

Dec 15, 2024 - NFL

Tennessee Titans
27 :  37
Cincinnati Bengals

Dec 8, 2024 - NFL

Tennessee Titans
6 :  10
Jacksonville Jaguars

Nov 17, 2024 - NFL

Tennessee Titans
13 :  23
Minnesota Vikings

Nov 3, 2024 - NFL

Tennessee Titans
20 :  17
New England Patriots
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 7, 2025 - NFL

Denver Broncos
20 :  12
Tennessee Titans

Dec 29, 2024 - NFL

Jacksonville Jaguars
20 :  13
Tennessee Titans

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Dec 1, 2024 - NFL

Washington Commanders
42 :  19
Tennessee Titans

Nov 24, 2024 - NFL

Houston Texans
27 :  32
Tennessee Titans

Nov 10, 2024 - NFL

Los Angeles Chargers
27 :  17
Tennessee Titans
Indianapolis Colts
Indianapolis Colts Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 14, 2025 - NFL

Indianapolis Colts
29 :  28
Denver Broncos

Sep 7, 2025 - NFL

Indianapolis Colts
33 :  8
Miami Dolphins

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Nov 24, 2024 - NFL

Indianapolis Colts
6 :  24
Detroit Lions

Nov 10, 2024 - NFL

Indianapolis Colts
20 :  30
Buffalo Bills
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 29, 2024 - NFL

New York Giants
45 :  33
Indianapolis Colts

Dec 15, 2024 - NFL

Denver Broncos
31 :  13
Indianapolis Colts

Dec 1, 2024 - NFL

New England Patriots
24 :  25
Indianapolis Colts

Nov 17, 2024 - NFL

New York Jets
27 :  28
Indianapolis Colts

Nov 3, 2024 - NFL

Minnesota Vikings
21 :  13
Indianapolis Colts

Oct 27, 2024 - NFL

Houston Texans
23 :  20
Indianapolis Colts

Tennessee Titans against Indianapolis Colts : Head to Head (H2H)

Tennessee Titans

0 %

Indianapolis Colts

100 %

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Oct 13, 2024 - NFL

Tennessee Titans
17 :  20
Indianapolis Colts

Dec 3, 2023 - NFL

Tennessee Titans
28 :  31
Indianapolis Colts

Oct 8, 2023 - NFL

Indianapolis Colts
23 :  16
Tennessee Titans

Tennessee Titans - Indianapolis Colts Key Points

  1. The Titans are 1-1 ATS this season
  2. The Titans are averaging 15.5 points per game this season
  3. The Colts are 2-0 ATS this season
  4. The Colts are averaging 31.0 points per game this season

Our Tennessee Titans vs Indianapolis Colts Prediction

Indianapolis has been a surprise team in the NFL, even two weeks into the season. This is largely due to the fact that quarterback Daniel Jones has been extremely effective. Add Jonathan Taylor as a running back to help balance the offense, and the Colts could continue their success against a bottom-tier Tennessee team.

Speaking of, the Titans may have drafted Cam Ward, but he has not looked sharp in his first two games. Granted, he is a rookie, but the Titans clearly do not have the talent around him to succeed. 

Tennessee’s struggles are likely going to continue before they improve; therefore, our Tennessee Titans vs Indianapolis Colts prediction is: Indianapolis Colts ML.

Prediction:

 

Indianapolis Colts ML

-198
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Tennessee Titans vs Indianapolis Colts Picks